Swanton Lab @SwantonLab
The Cancer Evolution and Genome Instability Lab is led by @CharlesSwanton and is based @TheCrick and @uclcancer. London, England Joined April 2016-
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Online Now: Subclonal immune evasion in non-small cell lung cancer dlvr.it/TLkxG2
Excited to share our new paper with Sheila's lab: we performed an in vivo genome-wide CRISPRa screen using a lung TRACERx PDX model to uncover drivers of brain metastasis. BACE1 emerged as a key hit - especially interesting given ongoing therapeutic efforts in Alzheimer’s.
Excited to share our new paper with Sheila's lab: we performed an in vivo genome-wide CRISPRa screen using a lung TRACERx PDX model to uncover drivers of brain metastasis. BACE1 emerged as a key hit - especially interesting given ongoing therapeutic efforts in Alzheimer’s.
CHIP is a common, age-related condition where mutated blood stem cells expand without causing blood disorders. CHIP raises the risk of hematological malignancies, chronic inflammatory diseases (like heart & lung disease), & lung cancer. This manuscript shows that CHIP somatic…
Great to see this collaborative paper out @NatureComms. @TimWitney's team developed a PET radiotracer that distinguishes high/low NRF2 antioxidant pathway activation, including in our @CRUKLungCentre PDX models. Congrats @hgreenwood93 and team! 👏 nature.com/articles/s4146…
🚨So proud to present the first study from our @CCG_UCL group together with @CharlesSwanton @NnennayaKanu and led by @ojlucas with key collaboration @Ward__Sophie and fundamental support @Rija_Zaidi_ @abi_bunkum & many others Out in @NatureGenet 👇 doi.org/10.1038/s41588… 🧵👇
Our TRACERx non-small cell lung cancer (NSCLC) patient-derived-xenograft (PDX) models are now available through CancerTools.org 🎉 A big thank you to Dave Pearce and the incredible @CRUKLungCentre team who have made this possible!
Our TRACERx non-small cell lung cancer (NSCLC) patient-derived-xenograft (PDX) models are now available through CancerTools.org 🎉 A big thank you to Dave Pearce and the incredible @CRUKLungCentre team who have made this possible!
Is Osimertinib over? Not at all IMO. We just need to think more deeply about patient selection. I’ll point (again) to our recent paper looking at Genome Doubling and TP53 in EGFR positive NSCLC with @SwantonLab nature.com/articles/s4146…
Today our study of the association between replication timing alterations and mutation acquisition during cancer evolution has been published in @NatureComms nature.com/articles/s4146…
Why do some patients benefit less than others from precision cancer medicine? We are excited to share our paper "Mixed responses to targeted therapy driven by chromosomal instability through p53 dysfunction and genome doubling” out in @NatureComms. nature.com/articles/s4146… 🧵
Patient-derived xenograft (PDX) models allow cancer researchers to study tumour tissue from patients in mice. Our @CRUKLungCentre paper @NatureComms describes 48 new PDX models and highlights the importance of intratumor heterogeneity in the development of cancer models (1/9)
Comment: Capturing heterogeneity in PDX models: representation matters nature.com/articles/s4146…
This study highlights the importance of considering primary tumor heterogeneity when using PDX models and emphasizes the benefit of comprehensive tumor sampling nature.com/articles/s4146…
New review out in @trendscancer from Chris Abbosh and @CharlesSwanton. Excellent summary of latest evidence & use case for ctDNA in NSCLC at diagnosis/landmark timepoints to help with staging and decisions around adjuvant treatment - worth reading #LCSM sciencedirect.com/science/articl…
Patient-derived xenograft (PDX) models are widely used and valuable tools in #CancerResearch. But there are limitations to how well these models can represent the genetic complexity of patient tumours @robhynds @SwantonLab buff.ly/4aNLqDh @CRUKresearch @TheCrick @uclnews
My @SwantonLab postdoc paper is now out @NatureComms. It was a huge privilege to work with the TRACERx team. Thanks to @AMIHuebner and Dave Pearce, as well as everyone else @uclcancer, @TheCrick and @CRUK_MI who made this happen.
My @SwantonLab postdoc paper is now out @NatureComms. It was a huge privilege to work with the TRACERx team. Thanks to @AMIHuebner and Dave Pearce, as well as everyone else @uclcancer, @TheCrick and @CRUK_MI who made this happen.
Extremely grateful and excited to have support from @CRUKresearch to work on cancer initiation with @SwantonLab @TheCrick! Ever grateful to @drjkrane @AFrankell for the supervision and mentorship
Extremely grateful and excited to have support from @CRUKresearch to work on cancer initiation with @SwantonLab @TheCrick! Ever grateful to @drjkrane @AFrankell for the supervision and mentorship
It has been great to collaborate with @hgreenwood93, @TimWitney and team on their investigation of a new PET-based approach for imaging NRF2 activation in NSCLC. A tour de force across cell lines, GEMMs and @CRUKLungCentre PDX models!
It has been great to collaborate with @hgreenwood93, @TimWitney and team on their investigation of a new PET-based approach for imaging NRF2 activation in NSCLC. A tour de force across cell lines, GEMMs and @CRUKLungCentre PDX models!
Absolutely stoked that 'Bug in the System: The past, present and future of cancer' has been picked up for Seriously - always a must-listen in my podcast app. Check out all 3 episodes here: bbc.co.uk/programmes/m00… #scicomm #cancer #cancerresearch #immunotherapy
Absolutely stoked that 'Bug in the System: The past, present and future of cancer' has been picked up for Seriously - always a must-listen in my podcast app. Check out all 3 episodes here: bbc.co.uk/programmes/m00… #scicomm #cancer #cancerresearch #immunotherapy
Come start your group at the Crick! 💡 We're looking for creative early career researchers in cardiac and vascular biology, or clinician scientists in any field, to join our faculty community. #AcademicJobs | #ECRChat Apply by 5 October ⬇️ crick.ac.uk/careers-study/…
Thank you @DrSidMukherjee for taking the time out of your busy schedule to visit @SwantonLab @WillHilliam @DrClareWeeden @CharlesSwanton to talk about our work on air pollution and lung cancer @TheCrick

Charles Swanton @CharlesSwanton
16K Followers 812 Following Cancer Evolution and Genome Instability, Lung Oncologist Air Pollution and Drug Resistance Fair Weather 🚴
Science and Innovatio... @CRUKresearch
26K Followers 2K Following We're here to support our broad cancer research community of 4,000 scientists and clinicians. For general Cancer Research UK news & fundraising follow @CR_UK
Dan Landau @landau_lab
11K Followers 3K Following Somatic evolution, cancer genomics, epigenomics (Weill Cornell/New York Genome Center). Hemato-oncologist (NYP). Discl.: https://t.co/7TBNcbcVCP
Elizabeth McKenna @ElizSMcKenna
18K Followers 5K Following Executive Editor of Cancer Discovery @CD_AACR, published by @AACR. @BBS_Harvard/@DanaFarber alum. Native New Yorker. Views/likes/RTs are my own. She/her
Nicholas McGranahan @NickyMcGranahan
4K Followers 562 Following Group leader at the CRUK-UCL Lung Cancer Centre of Excellence. Cancer genomics, bioinformatics, and somatic evolution.
The Francis Crick Ins... @TheCrick
55K Followers 1K Following We’re the Crick, a research institute in London. We’re no longer posting on this account, but you can find other ways to stay in touch in our pinned post.
Anirban Maitra @Aiims1742
31K Followers 3K Following Pancreatic cancer researcher, GI pathologist, husband, dad. Striving to improve the lives of patients with cancer. 🇺🇸 🇮🇳
The ICR @ICR_London
24K Followers 2K Following The Institute of Cancer Research is making the discoveries that defeat cancer. We're a top UK academic research centre, a postgrad college, and a charity.
Chris Tape @christophertape
4K Followers 2K Following Group Leader at @uclcancer. Studying how different cell-types collaborate to drive cancer.
eriksahailab @eriksahailab
3K Followers 55 Following we want to find out how life works because we're curious and because we'd like to improve the outlook for cancer patients
Rob Hynds @robhynds
2K Followers 2K Following Scientist studying epithelial biology, stem cells and cancer @EpiCENTR_ICH. ⚽️ @BCFC 🏃🏻♂️ @LondonHeathside
FrezzaLab @FrezzaLab
27K Followers 3K Following We are a group of metabolism-lovers, focused on mitochondrial metabolism. Tweets are from Christian. https://t.co/EbWsJo6DnZ
Nature Cancer @NatureCancer
38K Followers 337 Following Nature Cancer is a journal dedicated to publishing the latest advances across all areas of cancer research.
Nature Reviews Cancer @NatureRevCancer
75K Followers 1K Following Nature Reviews Cancer is a monthly review journal for researchers working on cancer. We, the editors, highlight the most exciting topics in cancer research.
Nature Genetics @NatureGenet
128K Followers 1K Following Nature Genetics is a monthly journal publishing high impact research in genetics and genomics. RT/like=interesting/relevant, not necessarily endorsement.
FabriceAndre @FAndreMD
15K Followers 503 Following Head of Research Division of @GustaveRoussy , @myesmo President Elect
Isidro Cortes-Ciriano @isidrolauscher
2K Followers 2K Following Research Group Leader at EMBL-EBI @emblebi & Associate Faculty at @sangerinstitute. @CR_UK Career Establishment Awardee. Cancer genomics.
Lewis Au @lewisjwau
530 Followers 611 Following GU & GI Medical Oncologist @PeterMacCC | Postdoc @Neeson_Lab @PeterMacRes | IO Predictive Biomarkers | Alum @TurajlicLab @TheCrick @ICR_London @royalmarsdenNHS
Trevor Graham @trevoragraham
4K Followers 621 Following Director, Centre for Evolution & Cancer @CEC_ICR @ICR_London Mixing maths, genomics & evolution. Early detection, metastasis & drug resistance. Bowel cancer.
Jason Sheltzer @JSheltzer
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FIONA FERNANDES @Ferns_Fiona_18
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Lucas Otero Laudouar @LucasOt63494267
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Ulysse Baruchel @ulysse_baruchel
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Yash Pershad @yash_pershad
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Giuseppe Bosso @Giuseppebosso87
469 Followers 482 Following Post Doctoral Researcher at @CNIOstopcancer @Blascolab, Post-translational modifications Telomeres, Mouse models, Drosophila Genetics, Epigenetics
Linh N Tran @lntran26
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Center for Physical G... @PhysGenCenter
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Marika Reinius @MarikaReinius
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6 Followers 65 Following at GRC @AcadSinica Tumour-host interactions. Previously @ p53 & metabolism lab @TheCrick @CRUK_SI #cancer #metabolism #redox #hiring #labjobs
Sampsa Hautaniemi @Sampsa_H
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Jay N Pant @jnpant
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Ossian Longoria @OssianLongoria
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Mohammed Kabeer @kabeer_moh46162
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Columbia - Irving Ins... @Cancer_dynamics
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Amro E. Ali @amroeali
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Jasmine Kamboj, MD, F... @JasmineKambojMD
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Priscilla Cheng @Pris_Cheng
115 Followers 293 Following PhD student in the @BiffiGiulia Lab at @CRUK_CI @Cambridge_Uni Ellis Future Leaders Academy, @PancreaticCanUK Pancreatic cancer TME, fibroblasts and organoids
Kotaro Nomura @knomura_ncce
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Dr. Florencia Sánche... @MFSanchez_Lab
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Dr. Hwa Young @HwaDr23270
239 Followers 5K Following Nature, time and patience are the 3 great physicians. As a doctor, people will trust you, confide in you, and appreciate your efforts✨You can do amazing things.
Gulnaz Tabassum @gulnaz_jmi
27 Followers 266 Following Prime Minister's Research Fellow (PMRF)👩🔬@jmiu_official A budding Researcher on her way to find cure for cancer using miRNA based therapeutics.
Meg Poxon @MegPoxon
138 Followers 374 Following @DiMeN_DTP PhD student and GTA at Sheffield. KRAS mutations/macropinocytosis/PDAC. Freelance Associate @ Outsmart. Owner of a slightly spicy ginger cat 🐱
PRATITI MANDAL @PratitiIICB
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Hyojin Song @jinhysong
53 Followers 1K Following Postdoc @UCalgary - Bioinformatics | Patient Stratification | Precision Immuno-Oncology | Sarcoma+
Jatin Roper @jatinroper
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MD. Arafat Hossain @mdarafat21729
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Liam F. Spurr, MD @LiamSpurrMD
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Maria Vittoria Di Mar... @_mavidm
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PallabiBhattacharyya @Pallabi_B20
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Charles Swanton @CharlesSwanton
16K Followers 812 Following Cancer Evolution and Genome Instability, Lung Oncologist Air Pollution and Drug Resistance Fair Weather 🚴
Science and Innovatio... @CRUKresearch
26K Followers 2K Following We're here to support our broad cancer research community of 4,000 scientists and clinicians. For general Cancer Research UK news & fundraising follow @CR_UK
Elizabeth McKenna @ElizSMcKenna
18K Followers 5K Following Executive Editor of Cancer Discovery @CD_AACR, published by @AACR. @BBS_Harvard/@DanaFarber alum. Native New Yorker. Views/likes/RTs are my own. She/her
Nicholas McGranahan @NickyMcGranahan
4K Followers 562 Following Group leader at the CRUK-UCL Lung Cancer Centre of Excellence. Cancer genomics, bioinformatics, and somatic evolution.
The Francis Crick Ins... @TheCrick
55K Followers 1K Following We’re the Crick, a research institute in London. We’re no longer posting on this account, but you can find other ways to stay in touch in our pinned post.
The ICR @ICR_London
24K Followers 2K Following The Institute of Cancer Research is making the discoveries that defeat cancer. We're a top UK academic research centre, a postgrad college, and a charity.
Cancer Cell @Cancer_Cell
72K Followers 258 Following Cancer Cell provides a high-profile forum for showcasing advances in cancer research, with a strong emphasis on translational research.
Chris Tape @christophertape
4K Followers 2K Following Group Leader at @uclcancer. Studying how different cell-types collaborate to drive cancer.
Rob Hynds @robhynds
2K Followers 2K Following Scientist studying epithelial biology, stem cells and cancer @EpiCENTR_ICH. ⚽️ @BCFC 🏃🏻♂️ @LondonHeathside
Cancer Research UK @CR_UK
327K Followers 558 Following We’re the world's leading independent cancer charity dedicated to saving lives through research, influence and information.
FabriceAndre @FAndreMD
15K Followers 503 Following Head of Research Division of @GustaveRoussy , @myesmo President Elect
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4K Followers 621 Following Director, Centre for Evolution & Cancer @CEC_ICR @ICR_London Mixing maths, genomics & evolution. Early detection, metastasis & drug resistance. Bowel cancer.
NatureRevClinOncol @NatRevClinOncol
41K Followers 242 Following The latest clinical diagnostic, treatment & personalized medicine advances & more from Nature Reviews Clinical Oncology, a reviews journal.
Jason Sheltzer @JSheltzer
17K Followers 2K Following Assistant prof at @StanfordMed. Interested in aneuploidy, mitotic kinases, cancer therapeutics, and drug development. Co-founder x2.
Nuria Lopez-Bigas @nlbigas
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Dr Sophie Acton @ActonLab
5K Followers 5K Following Professor of Immunology /Cancer Research UK Senior Fellow @MRC_LMCB @UCL | Lymphoid tissue biology #immunity #cancer | #SciArt | @CRUKresearch
Florian Markowetz @markowetzlab
4K Followers 2K Following Computational Oncology at Cambridge | chromosomal instability | genomes and images | selfish about reproducibility | useless models | all fox, no hedgehog
Crispin Hiley @crispinhiley
2K Followers 1K Following Lung and Metastatic Cancer Specialist. Associate Professor. Consultant Oncologist. @uclh @uclcancer @CRUKLungCentre @genesiscare
ESMO - Eur. Oncology @myESMO
80K Followers 970 Following The European Society for Medical Oncology (ESMO) is a reference organisation for cancer education and information, supporting the oncology community’s work.
Debbie Caswell @drmcaswell
992 Followers 843 Following Principal Research Fellow @UCL | Lung cancer prevention laboratory
CRUKCOLcentre @CRUKCOLcentre
2K Followers 288 Following CRUK City of London Centre is a partnership between UCL, KCL, QMUL and the Crick aiming to transform cancer outcomes through effective biological therapies.
Emma Wall @dremmacbw
2K Followers 1K Following Clinician Scientist #infectiousdisease #COVID19 @TheCrick @UCLHResearch @uclh @HTropDis @UCLInfectImm Passionate about health & vaccine equity
Adam Pennycuick @adampennycuick
299 Followers 477 Following Oncologist @UCLH | Bioinformatician @lungsforliving | Founder @oslrapp | Early lung cancer, tumour aggression, MedEd, all things data 👨💻
Sue Duncombe @DuncombeSue
912 Followers 1K Following Proud to be a volunteer for Cancer Research UK. Approach to life - 'What are you waiting for?!' All views expressed are my own
Gina Stavrou @GinaStav_
299 Followers 2K Following Currently @uclcancer |Former researcher @Karaiskakio |MPhil Medical Science @Cambridge_Uni| MRes Cancer Informatics @ICR_London & @imperialCollege
Kristiana Grigoriadis @KristianaGrigo4
184 Followers 226 Following PhD Student in the @Swantonlab | @TheCrick | @uclcancer
Othman Al-Sawaf @Othman_Al_Sawaf
1K Followers 550 Following Emmy Noether Group Leader @CECAD_ Physician-scientist, Haematology & Medical Oncology. @UniCologne Visiting Scientist @TheCrick @SwantonLab
Sheila Singh Brain Tu... @sheilasinghlab
1K Followers 234 Following Human Cancer Stem Cell Biology Lab | Dr. Sheila Singh, MD PhD FRCS(C) | Tweets by lab members.
Sonya Hessey @SonyaHessey
170 Followers 79 Following CRUK City of London Clinical Research Fellow @UCLcancer Oncology Registrar @UCLH
Kerstin Thol @KerstinThol
271 Followers 397 Following postdocing @MSKCC CompOnc | alumni @UCLcancer | 🧬💃 🎉
Clare Weeden @DrClareWeeden
1K Followers 1K Following I'm a lung cancer researcher and also do other stuff (read books, look in the fridge). Laboratory Head @WEHI. Alumna @SwantonLab. She/her.
Ariana Huebner @AMIHuebner
137 Followers 262 Following
@weitinglu.bsky.socia... @Wtlu3
332 Followers 866 Following Tea addict and scientist, in that order. Incoming Group Leader, Dept of Oncology, University of Oxford. All views my own.
Alex Frankell @AFrankell
522 Followers 506 Following Research Group Leader @EarlyCancerCam @CRUKCamCentre and Wellcome Career Developement Fellow studying somatic evolution using non-invasive sampling
James L Reading @JL_Reading
915 Followers 818 Following UKRI Future Leaders Fellow & Group Leader @UCL | Pre-cancer Immunology, early detection, immune interception | Ex-swimmer, woeful centre back |
Epithelial Cell Biolo... @EpiCENTR_ICH
310 Followers 587 Following 🔬Stem cell biology and cancer research team @DBC_ICH and @UCLchildhealth 🥼Led by @robhynds and @colin_r_butler 📍@GreatOrmondSt & @ucl
James Black @jrm_black
906 Followers 770 Following @TheCrick postdoctoral clinical fellow studying Lung Cancer evolution. Doctor/bioinformatician/master of none.
Aśka (Joanna) Przewr... @PrzeAska
322 Followers 419 Following Scientist studying what embryonic and cancer cells have in common | @MSCActions fellow @Snippertlab and @MedemaRene | PhD from @SwantonLab @TheCrick II 🎨 🩰🚲
Simone Zaccaria @ZaccaSimo
875 Followers 274 Following CRUK Career Development Fellow Group Leader of @CCG_UCL at the UCL CI @CRUKLungCentre and Visiting Scientist at the Francis Crick
Jennifer Wargo MD @JenWargoMD
5K Followers 2K Following Professor of Genomic Medicine & Surgical Oncology, UT MD Anderson Cancer Center *tweets are my own*
Cian Murphy @DrCianMurphy
280 Followers 1K Following Postdoc in @SwantonLab. Medical Oncology Registrar at the Royal Marsden Hospital. Wannabe cyclist and tennis player.
Imran Noorani @drimrannoorani
823 Followers 3K Following NIHR Clinical Lecturer in Neurosurgery, @QSNeurosurgery; @UCL. Molecular oncology @TheCrick, investigating therapy resistance in #GBM @CR_UK
Peter Sasieni @petersasieni
2K Followers 2K Following Cancer screening, prevention, and early detection researcher at Queen Mary University of London
Dionysis Papadatos-Pa... @DionysisPastos
146 Followers 262 Following https://t.co/8aF2ixHFbP | specialist in lung cancer, mesothelioma and thymic tumors
Dhruva Biswas, MD/PhD @dhruva_biswas
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Will Hill @DrWilliamHill
1K Followers 2K Following Cancer cell biologist | Heterotypic cell-cell interactions and tumour evolution | postdoc @SwantonLab @TheCrick. Views my own
Emma Colliver @ColliverEmma
655 Followers 2K Following @TheCrick Visiting PostDoc | Cancer Research, Tumour Microenvironment |@Cambridge_Uni Physics Graduate | All views are my own
Chris Bailey @cbailey_58
430 Followers 528 Following Budding haematologist and PhD student at the Crick looking into Cancer Evolution. Funded by CRUK.
Vousden Lab @LabVousden
3K Followers 144 Following We study intrinsic cancer cell metabolism, crosstalk between tumour and stroma in TME, and the interplay between cancer and systemic conditions @theCrick
Lavinia Spain @SpainLavinia
122 Followers 253 Following
Peter Van Loo @VanLooLab
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Moritz J Przybilla @PrzybillaMoritz
314 Followers 585 Following PhD Student @sangerinstitute, former student @UniHeidelberg, Ex-iGEMer @iGEMHeidelberg - interested in #somaticEvolution and #riskprediction.
Mihaela Angelova @MihaelaAngel0va
107 Followers 255 Following
Nnennaya Kanu @NnennayaKanu
128 Followers 99 Following
Ninja Warrior UK @ninjawarrioruk
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Andrew Furness @ajsfurness
644 Followers 742 Following Consultant Medical Oncologist, Solid Tumour Cell Therapy Lead @royalmarsdenNHS & Team Leader @ICR_London; views my own
Quezada Lab @QuezadaLab
1K Followers 224 Following Immune Regulation and Tumour Immunotherapy Group led by @squezadd, based at the Cancer Institute of University College of London, UCL.
Pierre Martinez @DrPMartinez
372 Followers 258 Following CR / PI @ Inserm & @crcl, Lyon, France. Interested in cancer evolution and diversity: how to quantify, predict and control them. https://t.co/qiLEORIfb6
Katey Enfield @EnfieldKatey
277 Followers 329 Following Assistant Professor at @ubcpathology and Scientist at @BCCancer studying the evolving relationships between lung tumours and the immune response.
AttardLab @AttardLab
1K Followers 245 Following Understanding treatment resistance in prostate cancer @uclcancer. Tweets by Gert & team.
CRUK Manchester Insti... @CRUK_MI
6K Followers 650 Following We are a leading cancer research institute within @OfficialUoM funded by @CR_UK. Find out about our new research building here - https://t.co/PcnBqajwID