David Lu @_DavidLu_
G2 MD-PhD Candidate @StanfordMed, Khavari Lab | MSc Philosophy, Science, & Religion @EdinburghUni | BS @Yale, @lemmonferguson lab celestrascience.com Palo Alto, California Joined February 2021-
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Nature research paper: irCLIP-RNP and Re-CLIP reveal patterns of dynamic protein assemblies on RNA go.nature.com/3Y6lNtF
Assessing the functionality of over 4,000 genome variants for their role in cancer, with prominence of impact for those related to the immune system and chronic inflammation nature.com/articles/s4158…
I just read a recent Nature paper that only used one shRNA per gene for their knockdown experiments, didn't do any rescue experiments verifying that the shRNA-induced phenotype was an on-target effect, AND didn't even show qPCR or Western Blots confirming gene knockdown🤦♂️🤦♂️🤦♂️
“There are not, and will never be, KRAS inhibitors” 👀 @Pasca_Lab presents a memorable reviewer comment from her 1st unfunded NIH grant at #AACRPan24. The lesson is that you should not let deflating reviewer comments define the value of your science. Also, persistence!
Always ask what the training set is. ML models have their uses, and those uses are often close to home. We need more things directed at target selection & clinical outcomes, but also a LOT more data there to make the models work. science.org/content/blog-p…
Have been sitting on this for a few days and am now really excited to share *4* papers just published online today in @CD_AACR, with variations on the theme of cancer cell #plasticity as a mechanism of resistance to #KRAS inhibition aacrjournals.org/cancerdiscover… (🧵)
When you come across a paper that generates a large dataset (e.g., RNA-seq, CRISPR screen, etc.) that'd be incredibly useful for your own project.... but you look in the supplementary materials and realize the authors didn't include the raw data from the dataset:
It had me at "the normal intact adult pancreas harbours hundreds of pancreatic intraepithelial neoplasias (PanINs), almost all with oncogenic KRAS hotspot mutations" Spatial omics of pancreatic cancer nature.com/articles/s4158… @Nature @lauradelongwood @deniswirtz @AshleyKiemen
Really cool studies show that Alanyl-tRNA synthetase (AARS1) lactylates two of the most important proteins in cancer (YAP and P53) Treating cancers with beta-alanine inhibited lactate binding to AARS1 and in vivo tumor growth! cell.com/cell/fulltext/… jci.org/articles/view/…
To all the medical students: is this giving you Sketchy Micro vibes too?
To all the medical students: is this giving you Sketchy Micro vibes too?
Now online in @CD_AACR: Passenger Gene Co-Amplifications Create Collateral Therapeutic Vulnerabilities in Cancer - by @_YiBei, @anton_gh, Jan Dörr, and colleagues doi.org/10.1158/2159-8… @DKTK_ @ChariteBerlin @MDC_Berlin @berlinnovation
My job is just… lab
I thought I was the only one who felt this way in Teslas! Glad to know there are others
I thought I was the only one who felt this way in Teslas! Glad to know there are others
NEW content online! Advances in cutaneous squamous cell carcinoma dlvr.it/SqJWDf
Why inhibit only one KRAS mutant when you can inhibit multiple KRAS alterations at the same time. Our pan-KRAS inhibitor paper is out. nature.com/articles/s4158…
What are we doing here, people? Apparently cancer has been cured and it’s not even funny! Looks like I’m going to have to find a new career… 😂😂😂
This. Is. Amazing.
Great to see this collaborative study of ALK in neuroblastoma published - with the labs of our friends Yaël Mossé and Ravi Radhakrishnan: nature.com/articles/s4146…
Integrating single-cell and spatial transcriptomics to elucidate intercellular tissue dynamics go.nature.com/3zC9k3a #Review by Sophia K. Longo, Margaret G. Guo, @andrewlji & Paul A. Khavari @Stanford @StanfordCancer
Twierler @Twierler02837
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DataDrivenTrades🇺�... @Ruilew0852347
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Matthew Abikenari @Matthewabii
159 Followers 492 Following M.D. Candidate @stanfordmed | Clinical Neuroscience @uniofoxford | U.S. Herbruck scholar of Oxford | focused on Neurosurgical Oncology & Glial Immunology 🧠🦠
Amrita L. Ramanathan @amritalaxshmy
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treecashflow @treecashflow
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Diana Hla, MD @dianahla
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Gita Abhiraman, MD, P... @GitaAbhiraman
1K Followers 754 Following Resident @StanfordDeptMed. Prev Hertz Fellow @StanfordMSTP. BA Harvard Physics. Immune signaling, protein engineering, autoimmunity, cancer. Views my own.
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Medical Info @MedicalInfo_com
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Joseph @Joseph93906417
192 Followers 6K Following Corinthians 9:7 Each one must give as he has decided in his heart, not reluctantly or under compulsion, for God loves a cheerful giver🙏🏿❤️
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Lauren Clarke, MD, MA... @LaurenClarkeMD
303 Followers 697 Following Intern @SCVMCMed | Future PM&R Res @NorthwesternPMR | Past - MD @StanfordMed, MA @StanfordEd, MHA @USCPrice | #InclusiveHealth #MedEd #Physiatry | she/her🏳️🌈
Rodaba Rahim @rodabarahim
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Healthy @hataanji11776
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Shreyan Datta @Shreyan11_11
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Charlotte Herber @HerberCharlotte
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santiago @santiagokique
2K Followers 962 Following Vnzln aspiring physician-scientist 🇻🇪 | MD/PhD candidate @StanfordMed 🌲 Now on 🦋 at the same handle
Dan Nomura @DanNomura
19K Followers 9K Following Professor of Chemical Biology and Molecular Therapeutics at UC Berkeley; Departments of Chemistry and Molecular and Cell Biology; Co-Director of @MTI_UCB
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parodyyy @FolasewaAb92159
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William Shi @williamyshi
678 Followers 1K Following MD/PhD student @stanfordcbio @stanfordmstp | liquid biopsy, GU cancers, mental health
Ankur Parikh @ank_parikh
3K Followers 4K Following Staff Research Scientist at Google DeepMind. Former adjunct assistant prof at @NYU_Courant. PhD at @mldcmu. ML for Bio/Chem (Prev. NLP). All opinions my own.
ExplainTXT - AI Readi... @explaintxt
12 Followers 430 Following Helping readers to understand text faster. Highlight text and get instant short explanations. 📖
Alex Doan @alexdoan96
475 Followers 631 Following @DukeU '18 → @NIH→ @Stanford MD '25 → @OpNotes Surgery Resident In a world where you can choose to be anything, choose to be kind.
Shreya Shah @sas_shreya
363 Followers 541 Following MD/MBA Candidiate @Stanford | Aspiring Ophthalmologist and Patient Advocate
NIH @NIH
1.7M Followers 228 Following Official account of the National Institutes of Health. NIH...Turning Discovery Into Health®. Privacy Policy: https://t.co/wOGwZ3gX1M Engagement ≠ endorsement
JD Vance @JDVance
4.5M Followers 1K Following Christian, husband, dad. Vice President of the United States.
Lindsey Meservey @LindseyMeservey
52 Followers 103 Following Biology PhD student @Stanford working on protein-metabolite interactions
King L Hung @kinglhung
1K Followers 155 Following Biologist at Scripps, PhD at Stanford. Dynamics of genomes and cells.
Felix Horns @FelixHorns
1K Followers 201 Following Core Investigator at Arc Institute | Assistant Professor at Stanford | Synthetic biology, genomics, human health
Itai Yanai @ItaiYanai
32K Followers 2K Following Professor at the NYU School of Medicine. Co-host of the 'Night Science Podcast' @nightsciencepod and Co-founder of the Night Science Institute https://t.co/lede3rBmXU
Atul Butte @atulbutte
30K Followers 4K Following Chief Data Scientist @UofCAHealth・Director, Bakar Computational Health Sci Institute @UCSF_BCHSI・Distinguished Prof @UCSF・Entrepreneur・He/him・Opinions ⇨ my own
Milka Kostić, PhD @MilkaKostic
4K Followers 3K Following Director of @DFCI_ChemBio pursuing innovation, translation & transformation through #chemicalbiology. Opinions and views strictly my own!
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140 Followers 264 Following MD Candidate | Biomedical Informatics Master's @stanfordmed Biology | @stanford
Dr. ᐯᗩᒪEᖇIE �... @ValerieJHorsley
5K Followers 4K Following Valerie Horsley, Ph.D.• Scientist & Educator @yale • Mom • activist Mastodon: @[email protected]
Fischer Lab @fischerlab1
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5K Followers 110 Following Medicinal chemist, PROTAC and #TPD technology OXELTIS Scientist, https://t.co/F8c4eERuOA Communication Deputy for the SCT, https://t.co/8j34whJXIQ Tweets = my own.
Ryan Potts @pottslab
2K Followers 357 Following VP & Head of Induced Proximity Platform, @Amgen | Scientist | Father
Shreya Malhotra @malhotrashreya8
106 Followers 154 Following MD/PhD Student at Stanford 🌲(she/her/hers) UAB ‘20
Lauren Clarke, MD, MA... @LaurenClarkeMD
303 Followers 697 Following Intern @SCVMCMed | Future PM&R Res @NorthwesternPMR | Past - MD @StanfordMed, MA @StanfordEd, MHA @USCPrice | #InclusiveHealth #MedEd #Physiatry | she/her🏳️🌈
Ari Lamm @AriLamm
29K Followers 536 Following Host of Good Faith Effort, a podcast on the Bible and society @gfaitheffort. CEO, BZ Media. "Why Read The Bible In Hebrew?"
Tim Walz @Tim_Walz
1.2M Followers 2K Following Dad, husband, teacher, coach, veteran. 41st Governor of Minnesota. Official account: @GovTimWalz
Nancy Pelosi @SpeakerPelosi
8.0M Followers 490 Following Representative for CA-11, fighting for the people of San Francisco. 52nd Speaker of the House. Wife, mother, grandmother, dark chocolate connoisseur.
Bill Clinton @BillClinton
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61 Followers 82 Following MD/PhD student @StanfordMed | MIT ‘18 | Pine Crest School ‘14 | she/her
Charlotte Herber @HerberCharlotte
87 Followers 184 Following MD/PhD Candidate @StanfordMed, @stanfordneurds in @lisa_giocomo's lab | @NIHAging F30 Fellow
santiago @santiagokique
2K Followers 962 Following Vnzln aspiring physician-scientist 🇻🇪 | MD/PhD candidate @StanfordMed 🌲 Now on 🦋 at the same handle
Jk Gopakumar @Jk_Gopakumar
111 Followers 183 Following
Frances Arnold @francesarnold
70K Followers 765 Following Innovation by evolution, Linus Pauling Professor at Caltech, Nobel Prize in Chemistry (I am an engineer of the biological world)
Marques Brownlee @MKBHD
6.2M Followers 481 Following Web Video Producer | ⋈ | Pro Ultimate Frisbee Player | Host of @WVFRM @TheStudio
Ankur Parikh @ank_parikh
3K Followers 4K Following Staff Research Scientist at Google DeepMind. Former adjunct assistant prof at @NYU_Courant. PhD at @mldcmu. ML for Bio/Chem (Prev. NLP). All opinions my own.
Dr. Glaucomflecken @DGlaucomflecken
695K Followers 435 Following Ophthalmologist. Comedian. Speaker. Tiktok. Contact: [email protected] Bluesky: https://t.co/XXBQPt82Qg
Simon Barnett @SimonDBarnett
3K Followers 2K Following Partner + Head of Research @_DimensionCap | Focused on the Intersection of Compute + Bio | Prev: Public Biotech Investor | Chemical Engineering @JohnsHopkins
Michael Fischbach @mfgrp
6K Followers 724 Following Liu (Liao) Family Professor of Bioengineering, ChEM-H @Stanford.
Shreya Shah @sas_shreya
363 Followers 541 Following MD/MBA Candidiate @Stanford | Aspiring Ophthalmologist and Patient Advocate
Dr. Rhonda Patrick @foundmyfitness
611K Followers 213 Following Ph.D in biomedical science interested in nutrition, brain & aging. Host of FoundMyFitness podcast https://t.co/rirQwqebxL
Jay Bradner, M.D. @jaybradner
23K Followers 906 Following Physician-scientist making medicines with friends, memories with family. EVP R&D at Amgen
William J. Greenleaf @WJGreenleaf
11K Followers 121 Following Professor, Stanford University, Department of Genetics. Exploring the physical genome
Arjun Raj @arjunrajlab
27K Followers 2K Following Just another LLM. Tweets do not necessarily reflect the views of people in my lab or even my own views last week. https://t.co/fZAnUCqd12
Ash Alizadeh, MD/PhD ... @AshAlizadeh
4K Followers 3K Following @Stanford Professor. Hematologist/Oncologist & Cancer Geneticist. Computers, tumor genomes, ctDNA, immunology, lymphoma, diagnostics.
Historic Vids @historyinmemes
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Alex Doan @alexdoan96
475 Followers 631 Following @DukeU '18 → @NIH→ @Stanford MD '25 → @OpNotes Surgery Resident In a world where you can choose to be anything, choose to be kind.
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901 Followers 144 Following Assistant Professor of Cancer Biology @Penn_CBIO | Alumnus @broadinstitute and @MassGenBrigham | Tumor heterogeneity and plasticityTrends for United States
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