Zhenyu Liu @_LiuZhenyu
Research staff at National Cancer Center China, CAMS & PUMC. Cancer genomics & heterogeneities. liuzhenyu-yyy.github.io Beijing, China Joined April 2019-
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Zhenyu Liu retweeted
I loved this essay on scientific writing in @NatureBiotech (rdcu.be/edUCp). It highlights a key lesson I’ve applied throughout my career: the power of reading, thinking, and keeping a notebook with your ideas. Let me explain why this matters… 🧵👇
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Zhenyu Liu retweeted
Timescales in Cell Biology
Zhenyu Liu retweeted
1/: Excited to share our new study led by Luke Zappia on feature selection methods for single-cell RNA-seq data, now published @naturemethods ! We explore how choosing features impacts reference atlases & downstream analyses. 📊📚 nature.com/articles/s4159…
Zhenyu Liu retweeted
Out today in @Nature our work on the role of cell plasticity in shaping tumor evolution. Led by @perelli_luigi with critical contributions from @daweonline, Fei Chen and many other outstanding collaborators. 1/2 nature.com/articles/s4158…
Zhenyu Liu retweeted
Capturing cell-type-specific activities of cis-regulatory elements from peak-based single-cell ATAC-seq dlvr.it/TJLSkx
Zhenyu Liu retweeted
Now online in @CD_AACR: Single-Cell eQTL Mapping Reveals Cell Subtype-Specific Genetic Control and Mechanism in Malignant Transformation of Colorectal Cancer doi.org/10.1158/2159-8…
Zhenyu Liu retweeted
From the February issue: Tumor-intrinsic Kinome Landscape of #PancreaticCancer Reveals New Therapeutic Approaches aacrjournals.org/cancerdiscover… By Yi Xu, @itslaurapeng, @YehlabUNC, and colleagues @UNC_PHCO @UNC_Lineberger
Zhenyu Liu retweeted
nature.com/articles/s4158… (1/n) Ever wonder how transcription factors locate, "invade," and activate their enhancers during cell fate acquisition? 🧬🚀Check out our latest collaborative work with the Soufi lab, now published in @Nature!
Zhenyu Liu retweeted
🚨So proud to present the first study from our @CCG_UCL group together with @CharlesSwanton @NnennayaKanu and led by @ojlucas with key collaboration @Ward__Sophie and fundamental support @Rija_Zaidi_ @abi_bunkum & many others Out in @NatureGenet 👇 doi.org/10.1038/s41588… 🧵👇
Zhenyu Liu retweeted
A single-cell atlas of aging tissue demonstrates shared multi-omics of aging and cancer hallmarks nature.com/articles/s4358… @NatureAging @jacksonlab @justsaysinmice @OlgaAnczukow
Zhenyu Liu retweeted
Online Now: A genome-wide screen identifies silencers with distinct chromatin properties and mechanisms of repression dlvr.it/TGHjyy
Zhenyu Liu retweeted
Incredibly excited that our paper linking single molecule states of TF binding to gene expression using quantitative thermodynamic models is out in Nature today. An amazing collaboration with the Bintu Lab. Congrats to Ben, Michaela, and Julia! nature.com/articles/s4158…
Zhenyu Liu retweeted
tidyplots Time to say goodbye to ggplot2?🫡 "a significant reduction of code complexity" vs ggplot2 cran.r-project.org/web/packages/t… @JanBroderEngler bioRxiv 2024 biorxiv.org/content/10.110…
Zhenyu Liu retweeted
Now ONLINE - Article "Recapitulating the adenoma–carcinoma sequence by selection of four spontaneous oncogenic mutations in mismatch-repair-deficient human colon organoids" ✏️ @HansClevers and team @TheCleversLab nature.com/articles/s4301…
Zhenyu Liu retweeted
Excited to share our latest work published in @Nature, by grad student @mirazul302, currently on the job market. We uncovered clonal dynamics relating normal to tumor cells using natural and synthetic genetic changes. #SingleCell #DevBio #CRISPR #CRC #HTAN nature.com/articles/s4158…
Zhenyu Liu retweeted
Thrilled to share our paper now out @Nature delineating #plasticity during #CRC #metastasis, a fantastic collaboration led by @andrewrmoorman @elliebenitez11, and @f_cambuli from the @KarunaGaneshLab and @Dana_Per lab! nature.com/articles/s4158… rdcu.be/dYAVK. A 🧵
Zhenyu Liu retweeted
📚 Darwin, and then some: Understanding the core - and the limits - of the clonal evolution theory of cancer bit.ly/3YaIjAP
Zhenyu Liu retweeted
Today we report in @NatureGenet the genetic landscape of cancer drug resistance mechanisms from CRISPR base editing screens nature.com/articles/s4158…
Zhenyu Liu retweeted
NEW content online! Epigenomic heterogeneity as a source of tumour evolution go.nature.com/4dKLSUg
Another long-read single-cell omics technology from Tang Lab: scNanoSeq-CUT&Tag for profiling allele-specific chromatin modification and DNA-binding proteins even at repetitive elements in single cells. Congrats to Qingqing, Yuqing and Zixin! Read more at nature.com/articles/s4159…
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