Lucie Wolf @_LuWo
Working in cancer research at the Donnelly Centre at UofT. Interested in science communication and outreach. Joined March 2017-
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Proud to share our latest manuscript! 🎉 We quantitatively assessed how WNT5a is transported extracellularly at single-molecule and single-particle resolution. 👉 Read the full paper here: doi.org/10.1111/febs.7… 👇🧵
🚨Preprint Alert🚨 How does spatial&temporal organization shape Wnt signaling? 🧬🔬 🔍Using #GenomeEngineering, high-content #screening + phosphoproteomics, our study explores how Dvl2 centrosomal phase separation influences #WntSignaling outcomes 📄 doi.org/10.1101/2025.0… 🧵👇
🎉 Excited to share our latest work in @stemcellreports! This marks the final chapter of my postdoc in the @angerslab. cell.com/stem-cell-repo… 🧬✨ We show how individual Frizzled receptors regulate Wnt-β-catenin signaling kinetics in hPSCs, influencing mesoderm commitment🧵1/n
A team led by @UofT researchers has uncovered new targets that could be key to effectively treating #glioblastoma, a lethal type of brain #cancer. Glioblastoma is challenging to treat due to the resistance of its stem cells to therapy. Learn more 👉 uoft.me/Glioblastoma
Very cool to be featured in 'Humans of RHSE'! @RHSE_UofT @DonnellyCentre @StephAngers Read more about my postdoctoral work and beyond here: rhse.temertymedicine.utoronto.ca/news/humans-rh…
A team led by researchers at @UofT and @broadinstitute mapped the impact of #mutations on protein localization in the cell. They found that one in six disease-causing mutations led to #proteins ending up in the wrong location. Learn more 👉 uoft.me/Mislocalization
Our latest paper is out! In collaboration with @DrAnneCarpenter, we conducted a systematic high-content screen to understand the role of protein mislocalization in diverse human disorders. 1/ cell.com/cell/fulltext/…
Congratulations to our 2024 Research Excellence Award Winners! 🥳 Postdoctoral fellows Athanasios Litsios and Lucie Wolf received the #award for their research on the role of proteins in the cell cycle and colon cancer. #UofT Learn more 👉 uoft.me/2024REA
It's a beautiful day at Niagara-on-the-Lake! 🌞 @DonnellyCentre faculty, trainees and staff are at Queen's Landing Hotel for our annual retreat. #DonnellyRetreat2024 #UofT
🔦Preview of Kschonsak et al.: Get your receptors in a knot with new Wnt signaling agonists by @_LuWo and @StephAngers at @UofT dlvr.it/T8YPWP
Incredible work by our collaborators @DonnellyCentre finally out in @Nature! Please read and RT this important contribution to the TPD/TPS field and congrats to @JulinePoirson, @mike_tilapia and the team! 🤗
Incredible work by our collaborators @DonnellyCentre finally out in @Nature! Please read and RT this important contribution to the TPD/TPS field and congrats to @JulinePoirson, @mike_tilapia and the team! 🤗
The origin and evolution of Wnt signalling go.nature.com/3I3R887 #Review by @MichaelaHolzem, @Michael_Boutros & Thomas W. Holstein @TWH00829518 @Boutroslab @UniHeidelberg @COSHeidelberg
It was a great pleasure to work on this exciting topic! Please check out my new Review article on The origin and evolution of Wnt signalling! go.nature.com/3I3R887 #Review by @MichaelaHolzem, @Michael_Boutros & Thomas W. Holstein @TWH00829518 @Boutroslab
exciting news for patients with macular edema!!! Our Frizzled4 Wnt agonist had a positive Ph1/2b trial! eyebiotech.com/eyebio-announc…
Pleased to share our latest preprint identifying a GTPase cascade that modulates regional Wnt signalling in the intestine: biorxiv.org/content/10.110…
New publication from the lab: Aged intestinal stem cells propagate inflammation. Congratulations to Maja Funk @funk_maja - great collaboration with @odom_lab @CancerInflam @haas_lab @angifeldmann @OliverStegle @DKFZ @UniHeidelberg #ageing #organoids cell.com/developmental-…
The WntUK network emerged from discussions between UK delegates at recent international Wnt meetings in Japan and Spain. The founding committee is comprised of seven Wnt scientists from all corners of the UK. Read more about the founding committee members below 👇 1/n
Congratulations and best of luck!
Congratulations and best of luck!
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