Sameer Aryal @_sameeraryal

Molecular mechanisms of neuropsychiatric disorders @broadinstitute. broadinstitute.org/~saryal Cambridge, MA Joined April 2013

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bioRxiv Neuroscience @biorxiv_neursci

12 months ago

Elevated synaptic PKA activity and abnormal striatal dopamine signaling in Akap11 mutant mice, a genetic model of schizophrenia and ... biorxiv.org/cgi/content/sh… #biorxiv_neursci

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Bryan Song @bryanjsong

11 months ago

Akap11 mutations greatly increase risk for #bipolar disorder and #schizophrenia. Not much was known about this gene when we started. Here’s what we learned! biorxiv.org/content/10.110… Thanks to Morgan Sheng, @ajgrange, Yang Ge, Borislav Dejanovic & crew @broadinstitute

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Francesco Longo @fran_longo17

2 years ago

Excited to share that our paper on cell-type specific changes in the striatal medium spiny neurons underlying the expression of RRBs in FXS mice is finally online @CellReports. Thanks to team members from @KlannLab, @CarterAG, @NicTritsch, and @BagniLab for their contribution!1/6

Klann Lab @KlannLab

2 years ago

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Ben Hobson @BenHobs3

2 years ago

Nat Biotech recently published a provocative study claiming single synapse RNA-seq. Unfortunately, there is no evidence demonstrating droplet-based sequencing of single synaptosomes. They are likely studying random pieces of cellular debris. Our reply: nature.com/articles/s4158…

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LabAnimal @LA_NatRes

2 years ago

🧵4/4 @_sameeraryal shows shared molecular changes in schizophrenia and bipolar disorder, offering new possibilities for understanding and treating these disorders!#MentalHealth #Schizophrenia #BipolarDisorder 🧠💡 👉 rdcu.be/dhoxC

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Broad Institute @broadinstitute

2 years ago

A deep, unbiased analysis of synapse proteins in brain tissue from individuals with schizophrenia, those with bipolar disorder, and unaffected individuals uncovers molecular evidence that these disorders have more in common than previously thought. broad.io/SynapseProteom…

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bioRxiv @biorxivpreprint

3 years ago

Spatially Resolved Single-cell Translatomics at Molecular Resolution biorxiv.org/cgi/content/sh… #bioRxiv

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bioRxiv @biorxivpreprint

3 years ago

Deep proteomics identifies shared molecular pathway alterations in synapses of schizophrenia and bipolar disorder patients and mouse model biorxiv.org/cgi/content/sh… #bioRxiv

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Sameer Aryal @_sameeraryal

3 years ago

We carried out proteomics of synaptic fractions purified from the DLPFC of humans with schizophrenia and bipolar disorder. We found multiple interesting changes, some of which were also seen in mice lacking Akap11, a shared risk gene for both diseases. Happy to share the work!

bioRxiv Neuroscience @biorxiv_neursci

3 years ago

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Duncan Palmer @astheeggeggs

5 years ago

On behalf of the Bipolar Exome (BipEx) project, I'm excited to present our analyses of exome sequencing data from 13,933 bipolar disorder cases and 14,422 controls which highlights AKAP11 as a shared risk gene with schizophrenia: medrxiv.org/cgi/content/sh… (1/9)

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TJ Singh @TarjS

3 years ago

At long last, I am pleased to say that the SCHEMA consortium’s paper has been published online in @Nature (nature.com/articles/s4158…): analysis of >120K individuals shows that rare coding variants in 10 genes confer substantial risk for schizophrenia. (1/6)

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Francesco Longo @fran_longo17

4 years ago

Kudos to @_sameeraryal @KlannLab for another great paper out today in PNAS @PNASNews, showing the identities of dysregulated mRNAs and a molecular mechanism by which reduction of S6K1 prevents altered translation in FXS.

Klann Lab @KlannLab

4 years ago

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Sameer Aryal @_sameeraryal

4 years ago

Very happy to note that my paper detailing the majority of my PhD research was published today. Thanks so much Eric (@KlannLab) and Francesco (@fran_longo17) for all of your guidance and support.

Klann Lab @KlannLab

4 years ago

Very happy to note that my paper detailing the majority of my PhD research was published today. Thanks so much Eric (@KlannLab) and Francesco (@fran_longo17) for all of your guidance and support.

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Francesco Longo @fran_longo17

4 years ago

Thrilled to share our last paper out today with @SpringerNature in Molecular Psychiatry. We show how proper regulation of PERK-eIF2α signaling in DA neurons is required for normal cognitive and motor function. Grateful to @KlannLab and team members from Margaret Rice's lab 1/5