Tobias Wolfram @_twolfram
Psychometrics, Sociogenomics, Behavioral Genetics, Statistical Genetics. twolfram.com Joined September 2018-
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The impact of location on a child’s outcomes are small but definite. Here, the authors use the random assignment of military families to different bases to get around selection. A 1 SD better neighborhood for 20 years raises SAT score by 40 points. 1/
@herasight found that many Nucleus polygenic scores used few SNPs, with much lower performance than implied by their reports, potentially misleading customers about disease risk (thread below). Instead of responding to these criticisms, they release more marketing hype.…
@herasight found that many Nucleus polygenic scores used few SNPs, with much lower performance than implied by their reports, potentially misleading customers about disease risk (thread below). Instead of responding to these criticisms, they release more marketing hype.…
Check out Tuomo Hartonen’s blog post on our study out today in @NatureGenet comparing electronic health record-based risk scores with genetic polygenic scores, and how they work better together! tuomohartonen.substack.com/p/medical-reco…
Quick blog post: The genetics of gluttony One in 400 people have a mutation that strongly increases risk of obesity. What is the subjective experience of having a mutation like this? crimsoniris.com/blog/the-genet…
Impressive paper by EPIC. They built a autoregressive transformer on 150M individuals and 115 billion medical events. Including: diagnoses, medications, lab values, procedure Cons: model is not shared (and unlikely will be) arxiv.org/pdf/2508.12104
about 1 in 500 men have an XXY karyotype, i.e. two X chromosomes. 75% of them are unaware of this. associations include: - 16x odds of infertility - 5x odds of venous thrombosis - several others Interesting study!
about 1 in 500 men have an XXY karyotype, i.e. two X chromosomes. 75% of them are unaware of this. associations include: - 16x odds of infertility - 5x odds of venous thrombosis - several others Interesting study!
The "First Law of Behavioral Genetics" states that all traits are at least partially heritable. But @eawilloughby and her colleagues found an exception to the Law: beliefs about free will and determinism! Beliefs about fatalism and unpredictability had low heritability (in the…
Polygenic screening can be a powerful way for parents to improve their future children’s health, especially if they have a family history of disease. The best way to promote this technology is to help prospective parents understand it, not to pressure them into using it.…
Polygenic screening can be a powerful way for parents to improve their future children’s health, especially if they have a family history of disease. The best way to promote this technology is to help prospective parents understand it, not to pressure them into using it.…
Stage IV cancer is a rollercoaster - cliche but true - where one week you are completely non-functional and another you can hike up a large mountain (Mt Baden Powell, 2870m). I'm back in for chemotherapy infusion 3/4 of this round on Tuesday, which will floor me again for…
Personality genetics is advancing fast. @tuckerdrob and Dorret Boomsma collect the world's literature here with 5 secure findings: 1. Genetic effects on personality are sizable, summing across hundreds of small genetic variants. 2. Personality genetics drives associations with…
Causal inference is all the rage. But good descriptive research is vital. This new article lays out an argument for what makes good descriptive research.
🚨 My new paper! How can we improve polygenic score (PGS) performance across diverse populations? I benchmarked leading PGS methods across EUR, AFR & EAS ancestries — and found a simple, accurate, and efficient approach. 🔗 tinyurl.com/6cmvxnu2
Jonathan Anomaly sits down with philosopher Allen Buchanan to discuss the ethics of polygenic embryo screening.
🚨 Our parent-of-origin study is out in @Nature ! 🧬 Maternal and paternal alleles can have distinct — even opposite — effects on human traits, revealing a hidden layer of genetic architecture that standard GWAS miss. 🔗nature.com/articles/s4158… Highlights below!
✅ Published in @Nature today, the paper describing the initial whole-genome sequencing analysis of 500,000 UK Biobank participants. nature.com/articles/s4158…
New Anthropic research: Persona vectors. Language models sometimes go haywire and slip into weird and unsettling personas. Why? In a new paper, we find “persona vectors"—neural activity patterns controlling traits like evil, sycophancy, or hallucination.
@slatestarcodex has written a great article on the burgeoning field of embryo selection, featuring our recently launched company @herasight. Scott has used the technology himself and gives an overview of the field - this is an essential read for anyone curious to learn more.
This stuff is seriously concerning.
This stuff is seriously concerning.
Great to see this launch of new polygenic scores for IVF embryo selection from the group at @herasight. Why I think this area/team is interesting (and I agreed to be an advisor to the company): 1. From a market perspective, having children is one of the few times that people…
Great to see this launch of new polygenic scores for IVF embryo selection from the group at @herasight. Why I think this area/team is interesting (and I agreed to be an advisor to the company): 1. From a market perspective, having children is one of the few times that people…
Happy to say we're coming out of stealth -- @herasight we've screened hundreds of embryos using in-house developed polygenic risk scores that are the most accurate in the field, alongside some other SOTA developments that we'll announce in the coming months. Check out…
Happy to say we're coming out of stealth -- @herasight we've screened hundreds of embryos using in-house developed polygenic risk scores that are the most accurate in the field, alongside some other SOTA developments that we'll announce in the coming months. Check out…
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