Ahmed K. Oraby @ahmedkhottary
Postdoctoral Fellow @UAlberta_MMI working at the interface of Med Chem, virology, CADD and ChemBio. PhD in Organic and Medicinal Chemistry @TheWestGroup1. orabychembio.com Edmonton, Alberta Joined October 2010-
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Ahmed K. Oraby retweeted
Congratulations, Prof. Huang!
Ahmed K. Oraby retweeted
🦠A new article in @Nature_NPJ npj Viruses describes a single RSV-F mutation (L305I) reshapes the antigenic landscape, enabling RSV to evade neutralizing antibodies, despite the site being distant from epitopes. nature.com/articles/s4429…
Ahmed K. Oraby retweeted
Appearing today in @ScienceMagazine : science.org/doi/10.1126/sc…
Appearing today in @ScienceMagazine : science.org/doi/10.1126/sc…
Ahmed K. Oraby retweeted
We characterized the catalytic properties, substrate scope and structure of KslB, an unusual Pictet-Spenglerase with the ability to form 1,1-disubstituted tetrahydrocarbolines: chemrxiv.org/engage/chemrxi…
Ahmed K. Oraby retweeted
The Discovery and Preclinical Profile of ALG-000184, a Prodrug of the Potent Hepatitis B Virus Capsid Assembly Modulator ALG-001075 | Journal of Medicinal Chemistry - hot off the press. This drug will enter phase 2 clinical trials in 2025. pubs.acs.org/doi/10.1021/ac…
Ahmed K. Oraby retweeted
A reminder on why you get higher hit rates from screening small molecules versus large ones. A one thousand member fragment library covers relative chemical space ten million times more than a one million member HTS library.
Ahmed K. Oraby retweeted
⚠️ BREAKING: Deadly Marburg Virus That Kills 9 Has Spread to Belgium, Hospital Visits Banned Following Deaths A major outbreak of the 'eye-bleeding disease' Marburg has potentially reached Europe, with experts warning it could spread globally.
Ahmed K. Oraby retweeted
Super excited to share our latest work on the native in-cell organization of the mitochondrial respiratory chain 🥳 Using cryo-electron tomography🔬, we show how the respiratory complexes (and other complexes) are organized inside native mitochondria! biorxiv.org/content/10.110…
Ahmed K. Oraby retweeted
🚨Job alert🚨Thrilled to share that the Gabr Lab received FIVE R01 grants for small molecule immunomodulators research. We are hiring postdocs with expertise in medicinal chemistry, neuropharmacology, or protein biochemistry. Applicants can send CVs to [email protected]
Ahmed K. Oraby retweeted
Excited to share our newest strategy to access carbenes from aldehydes - now via radicals! Young & Jake found this highly practical, efficient, & selective way to make triangles - that even works in the presence of air or water! @J_A_C_S pubs.acs.org/doi/10.1021/ja…
Ahmed K. Oraby retweeted
Ever dreamt of reaching into the base cabinet and grabbing the aqueous ammonia and potassium hydroxide pellets to run your amination reactions? (1/4)
Ever dreamt of reaching into the base cabinet and grabbing the aqueous ammonia and potassium hydroxide pellets to run your amination reactions? (1/4) https://t.co/1NphP4kfud
Ahmed K. Oraby retweeted
MEDICINAL CHEMISTS: Looking to increase your Fsp3? Synthesize in 3D just as you have been doing in 2D for eons by combining biocatalytic C–H oxidation and radical retrosynthesis (enabled by electrocatalysis). Appearing today in @ChemRxiv : chemrxiv.org/engage/chemrxi… . A fantastic…
Ahmed K. Oraby retweeted
A summary of Mpox outbreaks, new variants & deaths in South Africa and Africa that we are tracking and make data public in real time. Clade IIb causing first 2 deaths in SA and new variant, Clade Ib, emerging in mining town in DRC. A short thread ⬇️
Ahmed K. Oraby retweeted
Research Publications Controversial Take: it's not just about volume but impact. Focus on where your work truly contributes to the conversation. Less can indeed be more.
Ahmed K. Oraby retweeted
In a new Science paper, researchers describe how they stereoselectively snipped a C–H bond and added aryl groups to the position three or four atoms away from the carbonyl carbon of cyclic carboxylic acids: cen.acs.org/synthesis/c-h-…
Ahmed K. Oraby retweeted
This is a web app for determining column chromatography parameters based on TLC conditions which was put together by a member of our Discord - it's based off of earlier published work
Ahmed K. Oraby retweeted
The next chapter of our metal catalysis work is now on @ChemRxiv. We report that an unusual reversible Pd "ring-walking" process can be used to access unconventional isomers of cross-coupling products! doi.org/10.26434/chemr…
Ahmed K. Oraby retweeted
We're still looking for a motivated postdoc to help us investigate the role of bacterial biofilms in IBD. Pls RT Apply through this link: apps.ualberta.ca/careers/postin…
Ahmed K. Oraby retweeted
That amazing paper you spent years on? That amazing breakthrough you had? Very likely you built this following the work of others (very few exceptions), just as others will build off yours. Science is a continuum. Want to leave a lasting legacy in science? Be generous & be kind.
Ahmed K. Oraby retweeted
Check out this chemoenzymatic synthesis of prostaglandins by one of our former postdocs, now Prof. Jian Li; gram quantities of prostaglandins prepared and 100g scale enzymatic Baeyer-Villiger! nature.com/articles/s4146…
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