Now in press, some evidence that the “protofibrils” that #lecanemab binds in human brain are insoluble fibrils with the same structure as those found in plaques. And some evidence for neurotoxicity in the insoluble fraction of aqueous brain extracts. sciencedirect.com/science/articl…
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@andrewmstern @RaniSarkisMD Congrats Andrew!
@andrewmstern Does donanemab also bind to these species?