Andy Zeng @andygxzeng
MD/PhD candidate studying stem cells and leukemia @UofTMDPhD @UofTMedicine Toronto, Ontario Joined November 2019-
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A study published today in @NatureCancer from @PMResearch_UHN and @StJudeResearch has mapped how human blood #StemCells create the blood lineage and uncovered why blood #cancer lineages can sometimes switch following #chemotherapy. 🔗Read more: uhnresearch.ca/news/investiga…
B-ALL is a disease of B-cell development, but where exactly does this process get derailed? For some patients, it’s earlier than you might expect and involves cellular states capable of both lymphoid and myeloid differentiation capacity! See @IlariaIacobucc1’s tweetorial here:
B-ALL is a disease of B-cell development, but where exactly does this process get derailed? For some patients, it’s earlier than you might expect and involves cellular states capable of both lymphoid and myeloid differentiation capacity! See @IlariaIacobucc1’s tweetorial here:
Understanding leukemia cell development in AML🩸 Our recent study revealed 12 cell states as AML cancer grow and develop. The findings, critical for AML classification and precision medicine, were reported by Drs. John Dick & @andygxzeng's team @UHN. aacrjournals.org/bloodcancerdis…
Understanding leukemia cell development in AML🩸 Our recent study revealed 12 cell states as AML cancer grow and develop. The findings, critical for AML classification and precision medicine, were reported by Drs. John Dick & @andygxzeng's team @UHN. aacrjournals.org/bloodcancerdis… https://t.co/CLY0IJRYlC
Researchers have developed a map of normal hematopoietic cell differentiation and used it to examine how aberrant differentiation can lead to #AML, according to results presented by Andy Zeng, PhD: brnw.ch/21wShji #AACR25 @andygxzeng @UofTNews @pmcancercentre
Excited to see BoneMarrowMap out in press! Please check out the R package (now capable of classifying 100,000 hematopoietic cells in 10 minutes) and consider giving the paper a read for some insights into how differentiation goes wrong in AML!
Excited to see BoneMarrowMap out in press! Please check out the R package (now capable of classifying 100,000 hematopoietic cells in 10 minutes) and consider giving the paper a read for some insights into how differentiation goes wrong in AML!
🚨 Breakthrough in #leukemia research! Dr. John Dick & team @UHN have mapped how leukemia cells grow & change, uncovering 12 key patterns. This could lead to better diagnosis & more targeted treatments for AML patients. Read more➡️ uhnresearch.ca/news/decoding-… #CancerResearch
Read the commentary: Putting AML Differentiation States on the BoneMarrowMap, by Jonas Berger and Livius Penter, online now concurrent with #AACR25. doi.org/10.1158/2643-3…
Online now concurrent with #AACR25 #hematooncology Minisymposium talk by @andygxzeng and Dr. John Dick team @PMResearch_UHN: Single-cell transcriptional mapping reveals genetic and hierarchy-based determinants of aberrant differentiation in AML. brnw.ch/21wShfF
DeepSeek-R1 is great, but it still does not handle genomics yet :) 🚀 We’re thrilled to announce that IntegrAO (pronounced "integral") 🧬🔬—our new multi-omics integration framework—has been published in Nature Machine Intelligence! 📑 Paper: nature.com/articles/s4225… 💻 Code:…
Stem cell-like states confer poor outcomes in blood cancer—but what mechanisms drive this and how can they be therapeutically targeted? In our new preprint, we show how a single TF represses one enhancer to maintain a subset of high-risk leukemias: 🧵👇 biorxiv.org/content/10.110…
Delighted to share the first study from my group: "HIF-1 activated by PIM1 assembles a pathological transcription complex and regulon that drives JAK2V617F MPN disease", now under review. biorxiv.org/content/10.110…
On the very 1st day of my PhD, I’m so excited to share my work exploring #CH #CHIP in the tumour microenvironment, out now as a preprint! CH clones that infiltrate the TME (CH-Tum) are linked w/ inflammation & poor clinical outcomes. Thread below! 1/ doi.org/10.1101/2024.0…
Mutant HSCs in human clonal haematopoiesis have an attenuated response to inflammation and ageing, which may give them a selective advantage. Happy to share our new paper published in @CellStemCell: doi.org/10.1016/j.stem… A thread below… /1
Mutant HSCs in human clonal haematopoiesis have an attenuated response to inflammation and ageing, which may give them a selective advantage. Happy to share our new paper published in @CellStemCell: doi.org/10.1016/j.stem… A thread below… /1
Stem cell competition in human bone marrow. New study in @CellStemCell has found that resistance to inflammation gives mutated blood stem cells in human bone marrow a growth advantage over non-mutated stem cells. doi.org/10.1016/j.stem… @stephxie @UHN_Research @pvyas_oxford

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Students of U of T's ... @uoftmdphd
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