First case of ketamine tolerance from Mayo Clinic: pubmed.ncbi.nlm.nih.gov/38597410 To stay well, the patient required increasing frequency of #ketamine, until it no longer worked after 5 years. #depression #psychiatry
@chrisaikenmd This phenomenon was published several years ago: journals.lww.com/psychopharmaco…
I've been having monthly ketamine infusion for nearly 10 years. My dose of course increased from the first infusions (mostly in the first year), but it levels out for long periods of time. Over the past year I've had it reduced down about 15%. It still works wonders for me personally and I don't seem to be getting tolerated at all.
@chrisaikenmd Hopefully this is rare, but nothing surprising
@chrisaikenmd I just recently started Spravato after 30 years of minimal response to antidepressants. It's been life changing! After the initial 6 weeks, insurance approved weekly long-term therapy. How do I prevent tolerance?
@chrisaikenmd Uh oh you can't have Special K for breakfast every day then
@chrisaikenmd 🤦♀️ Thinking of Matthew Perry 🕯️ Thanking this 💩 is not true sobriety. But we can fool ourselves once it's legal !
@chrisaikenmd I think it was predictable result.