Chris Lo 💊🧬🧠 @chrislowh
PhD Candidate @SGDPCentreKCL | Pharmacist @HKUPharm | #genetics #psychiatry #mentalhealth London, England Joined April 2020-
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🚨 My new paper! How can we improve polygenic score (PGS) performance across diverse populations? I benchmarked leading PGS methods across EUR, AFR & EAS ancestries — and found a simple, accurate, and efficient approach. 🔗 tinyurl.com/6cmvxnu2
Millions are spent on parenting interventions. Are they effective at preventing mental health problems? Turns out we can’t be sure…only 2/32 of the reviews in our metareview were of high quality, highlighting the need for robust evidence synthesis. mentalhealth.bmj.com/content/28/1/e…
New study @NatureGenet identifies first genetic risk factor for long COVID. They compared DNA from 16,000 patients vs 1.9 million controls across 24 countries. Here are my key takeaways 👇
Polygenic risk score (PRS) tools are getting better and better! Yue Li & team at McGill report a major update to their PRS software, VIPRS (variational inference of polygenic risk scores) — now lightning fast & ultra-efficient. VIPRS reads ultra-compressed LD matrices (MBs not…
Who benefits from antidepressants? New research from IoPPN (@cathrynlewis, @chrislowh) shows how measuring antidepressant ‘switching can help scientists and clinicians understand why antidepressants work for some people and not for others kcl.ac.uk/news/who-benef…
Next up at our Data Science Meeting, @chrislowh from @KingsCollegeLon introduces T-Rx: an R package that simplifies the processing of prescription records into exposure periods and treatment-related #phenotypes. This toolbox makes it easy to work reproducibly across databases,…
Three quarters of people who have taken #antidepressants say they helped them "feel better" in new IoPPN research. Read more➡️kcl.ac.uk/news/three-qua… #SSRI @wellcometrust @EdinburghUni @NIHRMaudsleyBRC
🚨So delighted to see this work looking at the genetic overlap between depression symptoms and Alzheimer’s disease now published in @NatMentHealth @SpringerNature🚨 Read the paper here: 👉 nature.com/articles/s4422…
🚨So delighted to see this work looking at the genetic overlap between depression symptoms and Alzheimer’s disease now published in @NatMentHealth @SpringerNature🚨 Read the paper here: 👉 nature.com/articles/s4422…
Excited to be completing my first book “How psychedelics work” early in the new year. 12/13 chapters written. As I say in the intro, it could just as easily have been titled differently, like these:
Merry Christmas everyone 🎅🏻 Thank you for the messages today ❤️ WOW it’s been an emotional one 🥹 Tune in to @BBCBreakfast tomorrow morning 8.15am to watch us live and hear all about our day with the reds 😬🔴⚽️ YNWA!!
The 2023 ACC/AHA #AFib guideline recognizes AFib as a disease continuum that starts with patients at-risk but without diagnosed AFib (Stage 1) and progresses to those in a permanent state of AFib (Stage 4). Learn more from the AFib Guideline Hub: bit.ly/3Nge8Uo…
Our new paper is a pharmaco-epi study on associations of montelukast with neuropsychiatric conditions in children and adolescents
Our new paper is a pharmaco-epi study on associations of montelukast with neuropsychiatric conditions in children and adolescents https://t.co/R1SvBUoeS9
@chrislowh @uk_biobank @genscot @MatthewIveson @VangelisVassos @WrayNaomi @mcintosh2001 @alex_c_gillett @michelleukamp @ChiaraFabbri12 @heathersibley99 @SGDPCentreKCL @medrxivpreprint Switching patterns 👉Median time to switch: 28 days 👉 Switching to SSRI (50%), TCA (33%) or other drugs 👉More recent prescriptions had ⬆️switching %, ⬇️ shorter time to switch 📷4/7 - our favourite figure
Here’s my turn for a preprint :) Medrxiv link: medrxiv.org/content/10.110…
Here’s my turn for a preprint :) Medrxiv link: medrxiv.org/content/10.110…
interesting work by @lgilchrist1 on MR between metabolites and psychiatric disorders!
interesting work by @lgilchrist1 on MR between metabolites and psychiatric disorders!
🚨New preprint alert 🚨 from AMBER group @cathrynlewis Shoutout to @michelleukamp ‘s work on ‘self-reported #antidepressant response’ data using @uk_biobank mental health questionnaire data! Characteristics resembles known evidence of SSRI response in clinical trials.
🚨New preprint alert 🚨 from AMBER group @cathrynlewis Shoutout to @michelleukamp ‘s work on ‘self-reported #antidepressant response’ data using @uk_biobank mental health questionnaire data! Characteristics resembles known evidence of SSRI response in clinical trials.
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Acta Neuropsychiatric... @scnpjournal
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304 Followers 180 Following associate professor at University of Bologna #pharmacogenetics #depression Past: @Fondaz_Veronesi fellow, Marie Sklodowska Curie fellow at @SGDPCentreKCL
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