Complex Portal @complexportal
The Complex Portal is a manually curated, encyclopaedic resource of macromolecular complexes from a number of key model organisms. Also follow➡️@intact_project ebi.ac.uk/complexportal Hinxton, England Joined June 2017-
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🧠 Alzheimer’s research meets precision medicine 📊 IMEx data from IntAct & Complex Portal 🧬 How AD mutations disrupt brain protein networks 🔍 Variant pathways, APP, miRNA 🚀 Toward targeted therapies 🔗 doi.org/10.1002/pmic.7… #KalpanaPannerselvam #IntAct #AlzheimersSociety
🧬 New in IntAct: Curated dataset from Pichlmair lab reveals VZV–host interactions in SK-N-BE2 cells. NPHP4 identified as a restriction factor; S862N variant alters interactome. Congrats V. Girault et al! 🔍 Explore: ebi.ac.uk/intact/search?… #IntAct #HostPathogen #@a_pichlmair
🧠 Ever wonder how your tongue detects umami or sweetness? 🧂 Umami is sensed by a GPCR made of TAS1R1 + TAS1R3; sweet by TAS1R2 + TAS1R3. 🍜 Both trigger gustducin proteins, sending signals to your brain (and beyond). 🔬 Learn more: Complex Portal: tinyurl.com/ymd4ews9
Complex Portal release 251 is out! 5,190 manually curated biological complexes. ebi.ac.uk/complexportal/… (in sync with UniProt release 2025_03)
Do you work with reference proteomes? We are improving our pipeline: Increasing the number of proteomes Decreasing the number of proteins in UniProtKB Better representing the biodiversity of life Read more: insideuniprot.blogspot.com/2025/06/captur…
All our training & webinars are free and available on demand? Our live webinars are taking a summer break but you can access our recorded webinars & training material online. View all UniProt training: ebi.ac.uk/training/servi… UniProt YouTube channel: youtube.com/c/uniprotvideo…
🐍 From Dark Myths to Eco Allies: Celebrating #WorldSnakeDay Complex Portal holds curated venom complexes from Crotalus durissus terrificus, a South American rattlesnake with pharmacologically active venom proteins. 🔬 Explore these complexes: (See tinyurl.com/mz5hmzdf)
Intronic repeats play a role in evolution, gene regulation & disease. They're linked to disorders like Haemophilia. Cells keep them in check through RNAi-driven heterochromatin formation. See S. pombe CLR4 complex (CPX-9241) & learn about its role in transcriptional silencing.
Want to learn more about macromolecular complexes? Register for our webinar on 𝗝𝘂𝗹𝘆 𝟵𝘁𝗵, 𝟮𝟬𝟮𝟱! Discover more about our latest updates including the Complex Navigator & the integration of ML-predicted complexes (huMap3.0 & MuSIC). ➡️ Register:tinyurl.com/bdy6wttv
UniProt is a world-leading, freely accessible data resource that provides protein sequence and functional information to scientists worldwide. So what is the value of UniProt for the global scientific community? #FAIRdata #Bioinformatics
UniProt is a world-leading, freely accessible data resource that provides protein sequence and functional information to scientists worldwide. So what is the value of UniProt for the global scientific community? #FAIRdata #Bioinformatics
June features CUL4A (Q13619). Cullin4-RING E3 ubiquitin ligases (CRL4s) regulate processes including facilitating stalled fork stability & genome integrity. Search using GO:0080008 (tinyurl.com/2zhsy43s) & use the Navigator to explore our range of CRL4 complexes! #ubiquitin
Now published in @MolSystBiol embopress.org/doi/full/10.10…
It is Skin Cancer awareness month! Explore manually curated interactomes of proteins associated with familial melanoma in IntAct. Access the network in IntAct (tinyurl.com/26tc7xtm). #IntAct_EBI, #ComplexPortal, #UniProt, #MelanomaAwareness, #SunSafety, 😎📷🧴
May is skin cancer awareness month! We're highlighting Telomerase holoenzyme complex (CPX-265) featuring TERT(UniProt:O14746). See the complex in tinyurl.com/mt7u4wbs & visit UniProt for all melanoma-associated proteins tinyurl.com/mryjvyu7 #MelanomaAwareness, #SunSafety🧴
Thrilled to announce that the protein–protein interactions of 396 SLC transporters, from the RESOLUTE project, is now integrated into IntAct! Congratulations to #Superti-FurgaLab, #FabianFrommelt Explore the interactome at ebi.ac.uk/intact/search?…
We're excited to promote our range of Dynactin & Dynein complexes this month! Visit the Complex Portal to explore the respective orthologous and paralogous complexes! (ebi.ac.uk/complexportal/…) #Dynactin, #Dynein, #Intracellulartransport
IntAct is expanding its Inflammatory Bowel Disease dataset (lnkd.in/ejkr8tKx)! Our latest addition is the lncRNA GATA6-AS1 interactome, from K.E. Sosnovski et al. (2023) in Caco-2 cells (lnkd.in/eiYaFSdK). ➡️ Learn more about this! (lnkd.in/e2RSQEZZ)
Hey Spliceosome enthusiasts! Explore the Spliceosome's catalytic activity on pre-mRNA through a highly dynamic series of compositional states. Visit the CP & use the Navigator to compare human Spliceosome complexes from various points in their lifecycle (tinyurl.com/yy4fbcp2).
Complex Portal release 250 is out! 5,049 manually curated biological complexes. ebi.ac.uk/complexporta... (in sync with UniProt release 2025_02). Come explore our high quality manually-curated complexes.
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