🔬Viruses don’t just cause short-term illness.
Many stay in your body for life.
They speed up the aging process - in your immune system, organs, and even your DNA.
Here’s some examples, and why stopping them could help extend lifespan🧵
This is how generative A.I. could be used to design far better, more potent mRNAs (linear and circular) for the future for genome editing, engineered T cells, cancer therapy, vaccines
science.org/doi/10.1126/sc…@ScienceMagazine
What I love about interferons is their simplicity ;-)
But seriously a great @CellCellPress new review of IFNs that are our 1st line of defense vs infections and critical for many inflammatory an autoimmune diseases. cell.com/cell/fulltext/…
Predicting TCR antigen specificity at proteome‑scale with synthetic immune cells and machine learning.
I’m pleased to share our group's collaborative effort with Engimmune in this new pre‑print: biorxiv.org/content/10.110…
This is the largest single donation ever made to a U.S. university, college or academic health center and will transform cancer care.
#GiveCancerHellbit.ly/4oBHTji
Inspired by patients with #ISG15 deficiency, researchers have engineered a broad-spectrum, #mRNA based antiviral that displays activity against Zika virus, SARS-CoV-2, and influenza virus. @BogunovicLabscim.ag/3HCeyVj
As I wrote in SUPER AGERS, the immune system is the key to modulating our aging process and the opportunity to extend healthspan. Today @NatureAging 7 new articles, summarized here, that reinforce its central role
nature.com/articles/s4358…
Latest from us. Universal antiviral made! How? Transient gene therapy. Which genes? Only 10 suffice, out of thousands of antiviral host genes. How did we choose? Got inspired by patients and gene promoters. Read in detail 👇🏼 science.org/doi/abs/10.112…
Preventive cancer vaccines could harness a less-compromised immune system in vaccine recipients before their immune responses become affected by the advanced status of the disease itself. Here's a recent review of the field
nature.com/articles/s4157…rdcu.be/eAqSL
Conserved T-Cell Targets May Boost Universal Coronavirus Vaccine Development
A new #vaccine design pipeline could protect against emerging SARS-CoV-2 variants and pinpoint conserved T-cell epitopes across #respiratory viruses
@ljiresearch#Tcells#COVID19hubs.li/Q03C7B-K0
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Bluesky: @rnasociety.bsky.social
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4K Followers 345 FollowingThe leading family of journals in gene & cell therapy. Journals include Molecular Therapy, Methods & Clinical Developments, Nucleic Acids, and Oncology.