Nature Reviews Drug Discovery @NatRevDrugDisc
Editorial team of Nature Reviews Drug Discovery. nature.com/nrd London Joined April 2009-
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This new article analyses the evolution of the pipeline and market for obesity drugs, which is being transformed by GLP-1-based therapies nature.com/articles/d4157…
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Nature Reviews Drug Discovery retweeted
CRISPR transforms medicine by correcting mutations in blood disorders. HSCs can be edited ex vivo, then transplanted for a permanent cure. #GenomeEditing PMID:40659814, Nat Rev Drug Discov 2025, @NatRevDrugDisc @broadinstitute doi.org/10.1038/s41573… #AI #Pharma #BioMed #RNA…
Treatment of chronic obstructive pulmonary disease: current pipeline and new opportunities nature.com/articles/s4157… rdcu.be/eHOJ9 This new Review discusses progress with drugs targeting inflammatory cytokines such as IL-4 and IL-5, neutrophils, alarmins and kinases
RNA modification systems as therapeutic targets nature.com/articles/s4157… rdcu.be/eGTG8 This new Review discusses the disease roles of proteins that regulate RNA modification and progress in targeting them, such as the RNA-methylating enzyme METTL3 in cancer
Upcoming market catalysts in the fourth quarter of 2025 include FDA approval decisions on navepegritide for achondroplasia, relacorilant for Cushing syndrome and ziftomenib for acute myeloid leukaemia nature.com/articles/d4157…
Our latest research highlight covers two papers reporting novel NLRP3 inhibitors for inflammatory diseases nature.com/articles/d4157… For readers interested in the NRLP3 inflammasome as a therapeutic target, here's a review nature.com/articles/s4157… rdcu.be/eHePm
For readers interested in drugs based on fibroblast growth factors (FGF) such as the FGF21 analogue in development for MASH acquired by Roche, here's a review nature.com/articles/s4157… rdcu.be/eG4jg
For readers interested in novel drugs for the liver disease MASH such as the FGF21 analogue just acquired by Roche, here's a review nature.com/articles/s4157… rdcu.be/eG4hX
Nature Reviews Drug Discovery retweeted
Roche is buying 89bio, the maker of an experimental drug for a liver disease that’s attracted major pharma interest, in a deal worth up to $3.5 billion. trib.al/9ODGknA
New online: Synthetic lethality in cancer drug discovery: challenges and opportunities nature.com/articles/s4157… rdcu.be/eFDCl This Review discusses advances in the discovery and validation of synthetic lethal pairs, and the development of drugs that target them
New US$3.1 billion foundation takes big, long-term bets on bioscience, AI and the environment nature.com/articles/d4157… Lynda Stuart, president and CEO of the newly launched Fund for Science and Technology, discusses the philanthropic organization’s plans
Nature Reviews Drug Discovery retweeted
Present your research in front of the biggest names in RNA medicine, network and meet new peers. Poster + oral presentation spaces for abstracts still available> go.nature.com/4mhVASr @Alnylam @ionispharma @harvardstemcell @BostonChildrens @NatureBiotech @Nature @NatRevDrugDisc
Microsystem technologies for accelerating the discovery and translation of immunotherapies nature.com/articles/s4157… rdcu.be/eGqYy This new review describes how microsystems can address efficacy, toxicity, predictability and affordability challenges with immunotherapies
Breakthrough therapy designations in China and the United States nature.com/articles/d4157… This new article analyses breakthrough therapy programmes intended to help address unmet medical needs in the two countries
Novel drug candidates for hard-to-treat hypertension vie for blockbuster positioning nature.com/articles/d4157…
For readers interested in cancer therapies, this review discusses how metabolic dysfunction of CD8 T cells and NK cells can diminish their anticancer activity, and assesses therapeutic strategies to overcome this nature.com/articles/s4157… rdcu.be/eFqm2
Chemical modification and engineering approaches for guide RNAs can enhance or enable CRISPR-based therapies by addressing issues such as delivery, stability, editing efficiency and off-target effects - find out more in this review nature.com/articles/s4157… rdcu.be/eFb79
For readers interested in cancer therapies, this Review in our September issue discusses molecular pathways and effector functions by which neutrophils modulate cancer progression, and considers tractable therapeutic targets nature.com/articles/s4157… rdcu.be/eEVmh
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