🔥 VEXAS = when inflammation fuels clonal takeover 🔥
Somatic UBA1 mutations in HSCs don’t just cause inflammation—they thrive on it.
🧬 Mutant clones “poison” healthy HSCs via a cytokine storm (IL-1β, IL-18, CXCL10).
🧪 ER stress + senescence → resilience of UBA1mut cells.
🐭…
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