Septin proteins (~tens of nm) binding to membrane-coated beads discriminate between micron-scale beads of different radii - even though the beads are 100s of times larger. How can proteins span these scales? New preprint from my group with ideas! Thread! arxiv.org/abs/2210.12204

This is motivated by a series of experiments from @GladfelterLab by @kevcannon520 and others, observing single septin binding rates as a function of bead size. Here's a recent example: doi.org/10.1101/2022.0…

@diffusiveblob Beautiful ideas and simulations here! We are excited to have these insights into this fantastic problem.

@diffusiveblob For one, beads are very wonderful!