Chander S Digwal @digwal_chander
Joined August 2021-
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🌞🥼Summer intern shoutout! Ishaan presented his work from the last few months under the mentorship of Dr. Sahil Sharma @SsGq2009 at the student symposium last week . Congratulations Ishaan!🥳 We cannot wait to see what your future holds 🤓
Online now - PTMs as molecular encoders: reprogramming chaperones into epichaperomes for network control in disease dlvr.it/TMkyft
Fantastic review by @GabrielaChiosis and team connecting the epichaorome with the chaperone code
Fantastic review by @GabrielaChiosis and team connecting the epichaorome with the chaperone code
⭐️Very excited to share that our article 'PTMs as Molecular Encoders: Reprogramming Chaperones into Epichaperomes for Network Control in Disease' is out online now in @TrendsBiochem #PTMs #HSP90 #epichaperome #PPI #neuroscience sciencedirect.com/science/articl…
In memory of Len Neckers, whose pioneering work on #HSP90 and #PTMs laid the foundation for how we think about chaperone regulation. Our latest @TrendsBiochem review builds on this legacy to explore the formation and function of #epichaperomes. doi.org/10.1016/j.tibs…
Don't miss him in the MEDI: General Poster Session Tuesday, August 19, 2025, 6:00 PM – 8:00 PM Hall C – Walter E. Washington Convention Center Poster Board #: 577! #ACSFall2025 #posterpresentation #GRP94 #epichaperomics #glycosylation #drugdevelopment #medicinalchemistry
Are you attending #ACSFall2025? Keep an eye out for @digwal_chander, he will be presenting Targeting Aberrantly Glycosylated GRP94: Conformational Dynamics and Implications for Drug Design early next week! #GRP94 #epichaperomics #glycosylation #proteinproteininteraction #PPI
Accepted manuscript alert! Our review "#Epichaperomes: Redefining #ChaperoneBiology and Therapeutic Strategies in Complex Diseases" is now out in @RSC_ChemBiol #DrugDiscovery #NetworkMedicine #SystemsBiology #PrecisionTherapeutics pubs.rsc.org/en/content/art…
Sahil presented earlier this month at #AAIC2025 in Toronto @alzassociation. This work was supported by @_BrightFocus & @NIHAging and aims to advance #precisionmedicine in #neurodegeneration through the development of small molecule probes for #epichaperome imaging in #Alzheimers.
Have you checked out our latest @NatureComms article? Learn about how #phosphorylation can impact the conformation of the ubiquitous protein #HSP90 thus opening therapeutic avenues & drugging the undruggable #epichaperome #CancerResearch #PrecisionMedicine nature.com/articles/s4146…
🚨 Our review "#Epichaperomes: Redefining #ChaperoneBiology and Therapeutic Strategies in Complex Diseases" is now out in @RSC_ChemBiol as an Accepted Manuscript! #DrugDiscovery #NetworkMedicine #SystemsBiology #PrecisionTherapeutics doi.org/10.1039/D5CB00…
Epichaperomes: Redefining Chaperone Biology and Therapeutic Strategies in Complex Diseases - now published in RSC Chemical Biology pubs.rsc.org/en/content/art…
How do stressors remodel #brain function before symptoms emerge? &network-centric intervention strategies as a promising avenue for disease-modifying #therapy in AD #Alzheimers #epichaperomes #neuroscience #SystemsBiology #networkbiology #drugdiscovery researchsquare.com/article/rs-593…
🧠Beyond the Headlines: Ensuring Integrity While Advancing #Alzheimers Research Sensational headlines aren’t the answer. Accountability matters—but so does celebrating the science driving real solutions. communities.springernature.com/posts/beyond-t… #BiomedicalResearch #Neurodegeneration
🧠✨ "How do stressors remodel brain function before symptoms emerge?" Check out researchsquare.com/article/rs-593… exploring how progressive protein network miswiring drives #Alzheimer disease—and how these changes can be reversed. #Neuroscience #Network #SystemsBiology
💭Are you curious about how epichaperomes drive adaptability in cancer & stem cells? Start with this videobyte summarizing our latest research - out now in @NatureComms! #phosphorylation #canceresearch #epichaperomes youtu.be/L37A4O6gYMk?si…
Check out this video byte highlighting how #epichaperomes drive adaptability in #cancer and #stemcells! Adapted from @chiosislabmskcc recent publication in @NatureComms #signaling #proliferation #adaptation #proteinproteininteractions Video produced by @journalexperts
Selective neuronal vulnerability in #DownSyndrome & #Alzheimers explored. A collaborative study published in ActaNeuropathComms @BioMedCentral . link.springer.com/article/10.118… #Neuroscience #SelectiveVulnerability #Genomics #RNAseq #Neuropathology
Posted on @alzforum Chakrabarty S, Wang S, Roychowdhury T, Ginsberg SD, Chiosis G. Introducing dysfunctional Protein-Protein Interactome (dfPPI) - A platform for systems-level protein-protein interaction (PPI) dysfunction investigation in disease. Curr Opin Struct Biol. 2024
Posted on @alzforum Chakrabarty S, Wang S, Roychowdhury T, Ginsberg SD, Chiosis G. Introducing dysfunctional Protein-Protein Interactome (dfPPI) - A platform for systems-level protein-protein interaction (PPI) dysfunction investigation in disease. Curr Opin Struct Biol. 2024
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