Dirk Paul @dirk_paul
Integrative Genomics, Precision Medicine, Chronic Diseases, Drug Discovery @AstraZeneca @Cambridge_Uni | Parkrunner | Views my own Cambridge, England Joined October 2011-
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Dirk Paul retweeted
From @sangerinstitute and the CEU! Translating genetic changes into future health impact New resource helps bridge the gap between identifying genetic changes linked to health conditions & understanding how these changes impact biological processes 🔗tinyurl.com/3fs4prt3
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Dirk Paul retweeted
Five years on, few Britons think Brexit has been good for anything % saying Brexit has had a positive impact on... Control the UK has over its laws: 31% UK's ability to respond to COVID-19: 23% British politics: 12% UK's level of international trade: 11% British businesses: 11%…
Dirk Paul retweeted
📣Excited to share our paper in @NatureGenet! rdcu.be/d7mo0 Do plasma proteins mediate obesity’s effect on CAD risk? →Using two-step proteome-wide MR, domain-aware MR, epigenomics & scRNA-seq, we prioritized endotrophin as a mediator & potential therapeutic target A…
Dirk Paul retweeted
Today we’re launching the world’s most comprehensive study of proteins circulating in our bodies, which will transform research into new medical tests, drugs and treatments. Discover more: ukbiobank.ac.uk/learn-more-abo…
Dirk Paul retweeted
If you’re thinking about voting Reform, remember that they made you poorer.
Dirk Paul retweeted
Can genetics affect our iron levels and what impact can this have on our health? @eliasallara and colleagues explored how the body controls iron and highlight how having too much or too little can negatively impact health Read more here 👉 tinyurl.com/h5yk3sfb
Dirk Paul retweeted
Dr. @dirk_paul's study on cell type-specific roles in cardiovascular disease highlights the critical insights made possible by us. Find out about more researcher stories and our involvement: ow.ly/t2Lb50UocIf
Dirk Paul retweeted
Million Veteran Program & FinnGen teams are pleased to release v1 meta-analysis of MVP, FinnGen and UKBB GWAS data. This first version includes ~300 binary disease definitions across >1.5 M individuals. Browse scans at: mvp-ukbb.finngen.fi
Dirk Paul retweeted
Last autumn FinnGen hit its target of sampling close to 10% of the Finnish population with more than 500,000 participants. We are happy to announce that the results based on the full cohort are now publicly available for the whole research community: finngen.fi/en/results-bas…
Dirk Paul retweeted
Among British S Asians (individuals ancestrally from Bangladesh & Pakistan living in East London), a missense variant in PIEZO1 (MAF 3.9%, but very rare in non-SAS) leads to lower HgA1c & thus delayed T2D diagnosis nature.com/articles/s4146… @NatureComms
Dirk Paul retweeted
Want to use a cardiovascular disease🫀risk score for primary prevention, but unsure which is the best for your population?🧐 Our work compares CVD risk scores & provides a framework for selecting the most appropriate score. Just out in @LancetGH!👀⬇️ doi.org/10.1016/S2214-…
Dirk Paul retweeted
NEW: we may have passed peak obesity 🎉📈📉🙏 In what might be one of the most significant trends I have ever charted, the US obesity rate fell last year.
Dirk Paul retweeted
"'Gene misbehaviour' widespread in healthy population" a fascinating joint study from researchers @aidanbutty @minouye271 @Di_Angelantonio @JohnNDanesh @dirk_paul led by the @sangerinstitute spreaker.com/episode/gene-m…
Dirk Paul retweeted
Out today in @NatureGenet! Important new updates to the Polygenic Score (PGS) Catalog, & a new software tool that simplifies the calculation of polygenic scores in the context of genetic ancestry 👉 tinyurl.com/fa5ts5a3 @iamslambert @minouye271 @sritchie73 @Florent_Yvon
Dirk Paul retweeted
There is a huge need to understand how BMI affects long term multiple long terms diseases. This PhD is jointly with the University of Cambridge and AstraZeneca.
There is a huge need to understand how BMI affects long term multiple long terms diseases. This PhD is jointly with the University of Cambridge and AstraZeneca.
Dirk Paul retweeted
Interested in a 4-year PhD studying the genetics of BMI and comorbidities? Don't wait, apply for my @AstraZeneca-funded studentship w/ @MikeXiao_JIANG 🔗: jobs.cam.ac.uk/job/48333/ (due October 31)! @CAMBRIDGE_CEU @HLRI_Cambridge @Cambridgecardio @DPHPC @CambridgeATS
Dirk Paul retweeted
New online! A review of polygenic scores and their applications in kidney disease from @atlasmaths and @kirylukk go.nature.com/3zjRC9p
Dirk Paul retweeted
New research in Nature Genetics introduces MILTON, a cutting-edge machine-learning research tool that accelerates drug targets and biomarkers discovery, with potential to redefine the landscape of preventative health care: learn.az/6017WsgZD
Dirk Paul retweeted
ASCI members Krzysztof Kiryluk @kirylukk and Ali G. Gharavi @Columbia evaluate 3 cohorts and find monogenic kidney disorders are associated with an increased risk of kidney failure, higher eGFR decline rate, and lower rates of complete remission: buff.ly/3XBriRh
Dirk Paul retweeted
In @HGGAdvances' latest article, @kauralasoo and colleagues demonstrate that eQTL evidence is insufficient to identify causal genes from GWAS loci and highlight the importance of considering multiple data sources: cell.com/hgg-advances/f… #ASHG
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Kiki, PhD 🏳️�... @kiki_omics
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276 Followers 263 Following Wellcome Clinical Research Career Development Fellow & Hon Consultant Cardiologist @Cambridge_Uni | Jnr Research Fellow @Catz_Cambridge | BSCI/BSCCT committee
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