Eric Joyce @ericjoycelab
Associate Professor, @PennGenetics @PennEpiInst 3D Genome structure and function ericjoycelab.com University of Pennsylvania Joined July 2017-
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Eric Joyce retweeted
Dr. Randi Isenhart (@isenhartrandi) has a new 1st author publication for her work in the @ericjoycelab on: The length and strength of compartmental interactions are modulated by condensin II activity: dx.plos.org/10.1371/journa…
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Eric Joyce retweeted
We are deeply saddened by the loss of an esteemed colleague, friend, mentor & a pioneer in Drosophila & meiosis research. R. Scott Hawley was a dedicated supporter of GSA & a champion of genetics. Read an In Memoriam published in Genes to Genomes: buff.ly/3EoNQh8
Eric Joyce retweeted
Exciting news 📃🧬🔬 Today we report on the dynamics of a fascinating class of molecular motors, so-called SMC proteins in @CellCellPress doi.org/10.1016/j.cell…
Eric Joyce retweeted
Excited to share our latest work on bioRxiv! Using cell-cycle dynamics and NIPBL depletion, we show that long-range enhancer interactions can form de novo without loop extrusion. Alternative mechanisms, including LDB1 and YY1, may play key roles.biorxiv.org/content/10.110…
Eric Joyce retweeted
ft. @HarkeJailynn, Jeewon Lee, @SonCNguyen, Staci Rakowiecki, @rebecca_yunker, @doug_epstein, @ericjoycelab (@PennGenetics), Arian Arab, @Melike_Lak (@PennEpiInst) & @SHugelier (@UPennPhysiology) @MolecularCell cell.com/molecular-cell…
Eric Joyce retweeted
Our paper discovering a centromere-localized retroelement RNA is now out in @GenomeBiology 🎉! Transcription of this retroelement is higher in CENP-A chromatin where insertions of this element seem to occur preferentially. Pls check it out and RT! genomebiology.biomedcentral.com/articles/10.11…
Eric Joyce retweeted
Congratulations @HarshiniChandr8 💐 Using human neurons homozygously-engineered with familial AD mutations, she found a role for miswired promoter-enhancer multi-loops in dysregulated excitatory and inhibitory gene expression programs BioRxiv: doi.org/10.1101/2024.0…
Congratulations @HarshiniChandr8 💐 Using human neurons homozygously-engineered with familial AD mutations, she found a role for miswired promoter-enhancer multi-loops in dysregulated excitatory and inhibitory gene expression programs BioRxiv: doi.org/10.1101/2024.0… https://t.co/3lIfpfZ3nE
Eric Joyce retweeted
It's my pleasure to present the next big preprint from SheqLab! An exciting application of our O-MAP platform that I hope will transform the study of nuclear architecture. If you've ever wanted to dissect the subnuclear "neighborhood" around an individual locus, read on! (1/30)
Eric Joyce retweeted
🚨Inter-chromosomal contacts (‘kissing chromosomes’) organize human genome topology along a spatial gradient of genome activity (62 Hi-C datasets). Check rdcu.be/dZYQw, @NatureComms, @4DNucleome, @The3DGenome, @humangenomeorg, @netscisociety, @emblebi, @MoGen_Grads
Eric Joyce retweeted
Happy to share work with Hadi, Yao & @Maxime_Tortora characterizing the impact of dynamic CTCF barriers for cohesin loop extrusion biorxiv.org/content/10.110…
Eric Joyce retweeted
First preprint from the lab 🚨 How can enhancers regulate target promoters across vast genomic distances, and what is the role of cohesin loop extrusion in the process? biorxiv.org/content/10.110… (1)
Eric Joyce retweeted
Excited to share a new preprint! (1)🔬The nucleolus is the most prominent nuclear condensate, with a fascinating multilayered liquid-like structure, and is the site of ribosome biogenesis. But how does this multiphase architecture form and function? biorxiv.org/content/10.110…
Eric Joyce retweeted
1/🧬Does chromatin organization shape immune responses? Our recent study with @NickAdams_PhD led by Reizis Lab and @leonidmirny explores how cohesin, a key player in chromatin loop extrusion, controls the chromatin architecture essential for conventional dendritic cells (cDC)👇
Eric Joyce retweeted
📣Sharing the latest research from the @MRSantosLab, just released on bioRxiv! We found LINE1 RNA promotes nuclear compartmentalization to repress the 8-cell state in human embryonic stem cells. biorxiv.org/content/10.110… 👇Key findings:
Eric Joyce retweeted
We then show these changes are found within tissues and during aging. To learn more, check out our preprint! Thank you to all co-authors, the Buenrostro lab, and everyone at @HSCRB & @broadinstitute who made this work possible! biorxiv.org/content/10.110…
Eric Joyce retweeted
Speaker Spotlight: @MariekeOudelaar from the Max Planck Institute will share exciting research on the mechanisms behind 3D genome folding and its role in gene regulation during cellular differentiation. Don't miss it! Register here 👉 bit.ly/chromatin-2024 #chromatin2024
Eric Joyce retweeted
Eric Joyce retweeted
Happy to share work with @Maxime_Tortora on modeling the physical chemistry of cohesin loop extrusion! biorxiv.org/content/10.110…
Eric Joyce retweeted
Happy to share my thesis work, now online at bioRxiv. We show that LDB1 organizes Enhancer-Promoter interaction networks and can function independently of cohesin! biorxiv.org/content/10.110…
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