lithium high @high_lithium

🏆Congratulation to our winners 🏆: - Best oral communication : Nina Compagne from @univ_lille - Public award communication : Dr Li Gao @Roche -Best flash poster : Laura Voet @KU_Leuven - Best poster awards : @alex_hallatt, Rebecca Stevens, and Wenxin Felix Zu #EFMCYMCS23

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Second session of oral communication this morning started with @NicolaAshman6 from @Cambridge_Uni , followed by @EsbenSv from @AarhusUni, @marcin_drop from @jagiellonian from Jagiellonian University and Li Gao from LMU Munich. #EFMCYMCS23

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Special mention for Dr Jan G Felber from @LMU_Muenchen winner of the 2023 Symeres PhD Prize for excellence in chemistry in life science research. Congratulations 👏🏆

"Photocontrolling Microtubule Dynamics with Photoswitchable Chemical Reagents" - our chapter in Microtubules (Springer'22) is out! tinyurl.com/MT-photoswitch… Everything needed to choose & use #photopharmaceuticals for biology. Congrats @psychescope! @photopharma_lit @MolSwitches

Our review is now published! link.springer.com/protocol/10.10…

Joyce Meiring @psychescope

4 years ago

Our review is now published! link.springer.com/protocol/10.10…

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@LZeisel's 25-page monster paper out in Chem! A chemical probe with >million-fold selectivity for selenol reductase TrxR1 over cellular RSH: thanks to 4 layers of kinetic defence & Baldwin's rules free👉tinyurl.com/TrxR1; @Chem_CP Join our Chem & Bio👇tweetorial (1/12)!

.@ThornSesholdLab take photopharmacology in vivo: metabolically stable SBT switches photocontrol microtubules in organoids, fish, fly & frog. @high_lithium & @psychescope show GFP-compatibility. pubs.acs.org/doi/10.1021/ja…

In Vivo Photocontrol of Microtubule Dynamics and Integrity, Migration & Mitosis by Potent GFP-Imaging-Compatible Photoswitchable Reagents SBTubA4P and SBTub2M @LMU_Muenchen @ThornSesholdLab #Photocontrol #Microtubule #Dynamics #Mitosis #Photoswitchable pubs.acs.org/doi/10.1021/ja…

Congratulations to the #FiMC2022 Innovation Prize winners, Dr. Steffen Pockes @SteffenPockes and Dr. Oliver Thorn-Seshold @ThornSesholdLab! #medchem #chembio #pharma #drugdiscovery #medchemtalents #euromedchemtalents @YoungSciNet @EuroMedChem

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Photoswitchable Epothilone-Based Microtubule Stabilisers Allow GFP-Imaging-Compatible, Optical Control over the Microtubule Cytoskeleton (Thorn-Seshold) @psychescope @JuliaThornSes @ThornSesholdLab #OpenAccess thanks to #ProjektDEAL onlinelibrary.wiley.com/doi/10.1002/an…

Happy to share the pre-print on the optogenetic #microtubule severing tool (#optokatanin) I've been working on! Fast, reversible and highly localized blue-light-activated MT disassembly.✨ doi.org/10.1101/2021.1…

Excited to talk about my optogenetic #microtubule severing tool at #MotorsInQuarantine tomorrow.

Anne Straube (annestraube.bsky.social) @AnneStraube

4 years ago

Excited to talk about my optogenetic #microtubule severing tool at #MotorsInQuarantine tomorrow. https://t.co/lVPGCD73iM

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.@ThornSesholdLab and coworkers tune disulfide kinetics and thermodynamics to create redox probes that are selective for the reductant protein, thioredoxin. acspubs.co/Cz2950F0s8F

Do you want to learn how to use photo-switchable MT inhibitors to do super neat assays like this? @ThornSesholdLab and I wrote the most comprehensive review to date on how to use them! It will be published in Meth Mol Biol but you can also read it here: tinyurl.com/MTphotoswitch

GFP-compatible microtubule stabiliser photoswitches lighting up cells near you! doi.org/f4zr An epothilone v taxol faceoff with Li @high_lithium & Joyce @psychescope (Epo wins). Congrats Li, Joyce, Anna @UtrechtUni & @JuliaThornSes! @biorxivpreprint #photopharmacology

Second preprint within a week 🥳 They call it a one-two punch in boxing. Poor Microtubules can’t get a break from us. Photoswitchable epothilone-based microtubule stabilisers allow GFP imaging-compatible, optical control over the microtubule cytoskeleton biorxiv.org/content/10.110…

Awesome effort from Li Gao @high_lithium, @ThornSesholdLab & co-authors optimizing colchicine-like inhibitors using the SBT photo-switchable scaffold. SBTubA4P is water-soluble & highly potent, great for 3D organoid models, zebrafish embryo (shown), etc.! biorxiv.org/content/10.110…

in vivo photocontrol of microtubule dynamics, migration, division and development! bit.ly/3lUuCmh Li @high_lithium's photopharmacology monster lands at last. Congrats Li, @psychescope, @JuliaThornSes, & our 18 coauthors on this reagent development story! @biorxivpreprint

In vivo photocontrol of microtubule dynamics and integrity, migration and mitosis, by the potent GFP-imaging-compatible photoswitchable reagents SBTubA4P and SBTub2M biorxiv.org/cgi/content/sh… #bioRxiv

The latest and greatest photo-switchable colchicine-like #microtubule inhibitor from @OThornSeshold lab is out! Switchable with 405 nm and (unlike PST-1) GFP orthogonal. authors.elsevier.com/c/1cAy68jWWJjF…