Jacob Roberts @jacoberts
Working on making biomanufacturing better @Keasling_Lab @UCBerkeley he/him Joined October 2021-
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Congrats to our very own @allie_npearson for winning Best Poster Award at the @ ECI Biochemical and Molecular Engineering XXIII in Dublin, Ireland 🇮🇪 on her work uncovering the genetic basis of dicarboxylic acid metabolism. We are so proud! 💚🤍🧡
Macro: the challenge here is making forms of defense that are not also offense. I focus not on weapons or even counter-weapons, but on resilient infrastructure.
New preprint! Foldy is an open-source web app for interactive structure analysis. Research groups can set up their own Foldy instance so any member can easily predict structures with AlphaFold, dock ligands with DiffDock or Vina, and more! Preprint: biorxiv.org/content/10.110…
Great news! Our latest research on polyketide synthase engineering has just been published in @J_A_C_S. Our work presents innovative methods for synthesizing unnatural polyketides with important implications for novel drug and biomaterial discovery. pubs.acs.org/doi/10.1021/ja…
Happy to share that DiffDock was accepted to #ICLR and even happier to share new exciting results in the updated manuscript! Unlike previous docking methods, DiffDock retains a large part of its accuracy when run on computationally folded protein structures! A thread 🧵
@AnthropicAI 4/ Constitution
Finally out! Check how we improved the reductive glycine pathway via ALE and harnessed it for the production of lactate from formate!👇
The Keasling lab is now accepting undergraduate applications with availability on the follow projects. Apply by Friday 8/26 @ forms.gle/DysmuPRmDs6NQG… and indicate which project(s) interest you!
This is a great comparison of ML approaches to predicting protein activity/fitness. Explains differences well and arrives at a simpler & more accurate model. nature.com/articles/s4158…
I’m excited to introduce our Retro-Cascorder, out today in @Nature! This molecular device logs barcoded receipts of gene expression in a temporal genomic ledger. Sequence the ledger --> recover the history of gene expression. nature.com/articles/s4158…
Here at @SavageCatsOnly we are thrilled to present a review on rubisco. We focused on structure, mechanism, evolution and engineering attempts. We try, and fail, to conclusively answer the question "What exactly is holding this enzyme back?" 1/10 arxiv.org/abs/2207.10773
The age of metagenomic structure-prediction-based enzyme discovery is here. Using AF2 predictions of candidate enzyme sequences and ligand docking, this paper discovers a new terpene synthase with a previously unknown substrate: nature.com/articles/s4158…
Also, I'd like to highlight any databases/tools/webservers that make use of AF/RF models for structural search/comparisons. FoldSeek: search.foldseek.com/search 3D-SURFER: kiharalab.org/3d-surfer/subm… DALI: ekhidna2.biocenter.helsinki.fi/dali/ Am I missing any? (2/2)
Volumetric density of potential longhaul fuels: Jet A-1/SAF: 34.7 MJ/l H2 hydrides: 13.2 MJ/l Ammonia liq: 11.5 MJ/l Wood pellets: 11.0 MJ/l H2 MOF: 7.2 MJ/l H2 liquid: 6.4 MJ/l H2 gas: 4.9 MJ/l Li-ion battery: 0.7 MJ/l Discuss
Add.: the method is published in: pubs.acs.org/doi/full/10.10… and the application to protein-ligand complexes in nature.com/articles/s4146…
We have updated the AlphaFold-Multimer paper and code with a new set of protein complex models trained with an improved loss. These models reduce the number of steric clashes and improve accuracy. Code: dpmd.ai/af-multimer-os Paper: dpmd.ai/alphafold-mult…
@RolandDunbrack Hi - we've updated AlphaFold-Multimer now and it should greatly reduce the number of issues like this.
@RolandDunbrack Hi - we've updated AlphaFold-Multimer now and it should greatly reduce the number of issues like this.
Wow. “4 genes were knocked out…including one that encodes a molecule that causes an aggressive human rejection response. A growth gene was also inactivated to prevent the pig’s heart from continuing to grow…6 human genes were inserted…to make the porcine organs more tolerable”
Wow. “4 genes were knocked out…including one that encodes a molecule that causes an aggressive human rejection response. A growth gene was also inactivated to prevent the pig’s heart from continuing to grow…6 human genes were inserted…to make the porcine organs more tolerable”

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