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David R. Liu @davidrliu

Professor at Harvard, Broad Institute, & HHMI. Our lab integrates chemistry & evolution to illuminate biology & enable new therapeutics. IG/Threads: @davidrliu1 evolve.harvard.edu Massachusetts, USA Joined November 2008
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David R. Liu @davidrliu

4 weeks ago

A wonderful article by @DhruvKhullar on patients with progeria, the genetics behind this rare disease, and our ongoing efforts with PRF and @NIH to advance promising base editing outcomes in humanized progeria mice into a clinical trial. newyorker.com/magazine/2025/…

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David R. Liu @davidrliu

a month ago

Data from the second human treated with a prime edited medicine: a 56-year-old male with chronic granulotamous disease (CGD) had his bone marrow prime edited to insert the missing GT in NCF1, restoring NADPH oxidase function in neutrophils (DHR positivity) several fold beyond the…

David R. Liu retweeted
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Jonathan D. Grinstein, PhD @GrinsteinJ

2 months ago

Brilliant collab of @davidrliu (@broadinstitute / @Harvard) & Cat Lutz (@jacksonlab) shows that durable in vivo primed editing of a neurodevelopmental disorder proves the feasibility of creating bespoke gene-editing drugs for a single disease in parallel. insideprecisionmedicine.com/topics/transla…

David R. Liu retweeted
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Eric Topol @EricTopol

2 months ago

One-shot prime genome editing ("CRISPR 3.0") of the brain in vivo corrected AHC, a rare genetic disorder, in the mouse model. Another big step forward in the genome editing field. @CellCellPress @davidrliu and colleagues cell.com/cell/fulltext/…

David R. Liu retweeted
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Michael Pacold @MichaelPacold

2 months ago

Just published: nature.com/articles/s4158… Coenzyme Q10 (CoQ10) is critical for mitochondrial function and for controlling reactive oxygen species damage to biological membranes. Because CoQ10 is poorly bioavailable, new approaches are needed to promote CoQ10 synthesis. In our…

David R. Liu retweeted
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L'Express @LEXPRESS

2 months ago

💬 "L’humanité pourra bientôt agir sur son destin génétique" Le scientifique américain @davidrliu (@Harvard) a révolutionné les technologies d’édition du génome. En réécrivant l’ADN, ses "machines moléculaires" sauvent déjà des vies. 🧵 1/6 👇 l.lexpress.fr/tkQ

David R. Liu retweeted
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Breakthrough @brkthroughprize

3 months ago

The Gene Editor: 2025 Breakthrough Prize winner David Liu introduces base editing and prime editing, the transformative technologies that could repair almost any genetic mutation.

David R. Liu retweeted
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Broad Institute @broadinstitute

2 months ago

Gene editing pioneer @davidrliu discusses baby K.J. Muldoon, the first person treated with a customized gene editing therapy, what made K.J.'s treatment possible, and how on-demand treatments for rare genetic diseases could one day become routine. broad.io/DLQA

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