FROM CELL DEATH TO REGENERATION: What if dying cells -come back to life? Now online @embojournal I tinyurl.com/yp8m7he6 , we aim to answer this question. Here is the journey. If you🩷science, please dont 🛑till the end of 🧵, I promise you will not regret. 1/n
Our latest story describes the amazing evolutionary battle between malaria parasite and human. The parasite evolved RIFINs to bind inhibitory KIR receptors and suppress immune cell function while humans have activating KIR receptors to bind these RIFINs to kill parasites!
In the silence of chromatin, Toxoplasma whispers change. TgSNF2h sculpts the genome - MORC in the backseat. Some genes wake. Others sleep.
A dance of nucleosomes shaping space for life parasite stages to unfold.
rdcu.be/ehkWpdoi.org/10.1038/s41564…
Postdoc Position Available
I am seeking an enthusiastic postdoctoral researcher to join my lab @OMRF, studying Astyanax mexicanus cavefish to explore metabolic adaptation. Ideal candidates should have a strong background in metabolism and basic molecular biology skills. Please RT
It's really sad, this closure of veupathdb.org It deprives thousands of parasitologists around the world... At a time when the world is questioning democracy, this illiberal act endangers global research on endemic and neglected diseases.
science.org/content/articl…
How does the deadly human-infective pathogen Entamoeba histolytica recognise our cells and cause liver abscesses? Check out our latest study, led by @SFGerard2018. Sam shows the structure of the critical amoeba lectin and how it recognises carbohydrates found on human cells.
Delighted to share our latest story with Joshua Tan's group, a deep dive into the natural infection antibody response to RH5, out now in Cell. cell.com/cell/fulltext/… 1/n 🧵
Fantastic work from @MehrotraPa in @kodiravi lab. I was fortunate enough to watch this project come together from start to finish and Parul's scientific rigour and creativity was a joy to experience. nature.com/articles/s4158…
Excited to share our new vaccine immunogen, designed through structure-guided methods, to prevent Plasmodium vivax. While the PvDBP antigen reduces parasite multiplication when used as a vaccine, it does not protect. PvDBP is also difficult to make. Could we make it better?
How does infection with helminths reduce asthma and allergies? Check out our recent paper showing how the helminth secretion product, HpAIR blocks IL-33 signalling. Cunning little parasite! Led by @jamwalabhishek and fun collaboration with @HenryMcSorley,
rdcu.be/dLewH
Very excited to share this animation of CaMKII that I created last year for @reichowlab
This enzyme regulates the synaptic plasticity underlying learning, memory and cognition
🟡 Kinase domain
🔴 Ca2+ calmodulin-binding domain
🔵 Hub domain
#blender#animation#b3d
#MeetTheResearcher
Introducing @nawsad_alam from Professor Matt Higgins' lab. As a postdoctoral researcher, Nawsad uses structure-guided approaches to design effective blood-stage #malaria vaccine candidates.
Read about a fascinating evolutionary battle between the malaria parasite and the human host in our new pre-print below!
Parasites have evolved to bind to inhibitory immune receptor KIR2DL1 while the host has a counter-offensive trick up its sleeve...
biorxiv.org/content/10.110…
@ZebrafishRock I'm planning my fish facility and would love to know from the community which company I should get the racks and the whole setup from. Which company did you you go for and what are the pros and especially the cons?
Thank you!
This immungen elicited a high-quality growth inhibitory response. We also showed that a first dose of this highly focused immunogen, followed by subsequent doses of the broader immunogen, PfRH5, was most effective. Read all about it here:
biorxiv.org/cgi/content/sh…
This immungen elicited a high-quality growth inhibitory response. We also showed that a first dose of this highly focused immunogen, followed by subsequent doses of the broader immunogen, PfRH5, was most effective. Read all about it here:
biorxiv.org/cgi/content/sh…
After years of hard work, I am pleased to share our Latest MolCell Paper on how we dissected the function of the only conserved transcription factor NusG in live E.coli. thanks to @AchillesKap@ojp25@M_Stracy, Max Gottesman, and all the Kapanidis lab.
sciencedirect.com/science/articl…
1K Followers 627 FollowingAssistant Professor of Biochemistry and Biophysics; Associate Director, Institute of Structural Biology, University of Pennsylvania
208 Followers 364 FollowingParaFrap PhD student working with epigenetics in Toxoplasma 🧬🔬.
Now also in https://t.co/RQGusftk44
From Buenos Aires, Argentina
2K Followers 1K FollowingPrincipal Investigator, Sir Henry Dale Fellow, new mom. My lab studies #Cryptosporidium biochemistry and drug discovery at the University of Dundee. She/Her
49 Followers 110 FollowingPostdoctoral Research Associate in the Higgins Lab, University of Oxford. Structural biologist in host-pathogen interactions.
https://t.co/eLL34BqW9R
442 Followers 239 FollowingWellcome Trust Career Development Fellow at Dept of Biochemistry, University of Oxford | likes taking things apart & putting them back together | 📸🔭
54 Followers 55 FollowingInfectious disease researcher and structural biologist @HZBmxde, likes shooting protein crystals with X-rays. Opinions are my own.
260 Followers 296 FollowingWorm Molecule Hunter in McSorley Lab and Smits Lab👩🏻🔬Immunologist interested in parasite molecules🪱 immunomodulation in allergy and inflammation ⚖️
853 Followers 638 FollowingGroup leader at Dept Biochemistry, University of Oxford. Dad/husband at home. Fascinated by motors, microtubules and malaria all the time.
2K Followers 460 FollowingMolecular Parasitologist. Teacher. Fascinated by how parasites interact with the immune system. Rational vaccine designer. Country boy and nature lover. 🏳️🌈
1.1M Followers 2K FollowingFlaneur: probability (philosophy), probability (mathematics), probability (real life),Phoenician wine, deadlifts & dead languages. Greco-Levantine.Canaan. #RWRI
42K Followers 5K FollowingJust Improvising | Policy and Polity | Comics | Lego | Movies | Books | Capitalists Outlive Communists in Darwin's World | Fan of Technicalities | Numbers First
21 Followers 31 FollowingMale, 35, Indian, Researcher in Biology, Likes to indulge in competitive activities like sports and games, aspiring to be a good dad
1K Followers 627 FollowingAssistant Professor of Biochemistry and Biophysics; Associate Director, Institute of Structural Biology, University of Pennsylvania
2K Followers 194 FollowingMolecular and biochemical research into the parasite causing the neglected tropical disease leishmaniasis. Director of YBRI. Co-director of DiMeN.
776K Followers 502 FollowingSenior Advocate,Delhi HC/SCI. Civil Commercial & Constitutional litigator. Author of #1 India that is Bharat, & #2 India, Bharat and Pakistan (Bloomsbury).
6K Followers 1K Followingchemical/synthetic biologist, Luddite trying find better ways to make molecules that do important stuff, dad, @uchicago professor of chemistry
208 Followers 364 FollowingParaFrap PhD student working with epigenetics in Toxoplasma 🧬🔬.
Now also in https://t.co/RQGusftk44
From Buenos Aires, Argentina
488 Followers 126 FollowingWe have moved! https://t.co/MfDVdb4ryk
This account will only post preprints!
For threads, job posts, and general science fun come find us over there!
1K Followers 206 FollowingWe focus on answering core questions in the biomedical field around topics such as diabetes, neuroscience, cancer and infectious diseases.
90K Followers 195 FollowingExpert on evolution of #Sikh identity & #Khalistan terrorism. Think & speak from FirstPrinciples. Deep interest in Auteur Cinema, Dharma, Religious Cults, Econ.
1K Followers 638 FollowingWellcome Centre for Anti-Infectives Research,University of Dundee. Our aim is to accelerate drug discovery process for neglected tropical diseases. #beatNTDs
14K Followers 2K FollowingLawyer practising in Delhi. Eager to learn about things unknown. RTs are not personal endorsements. Check out my sports podcast https://t.co/AXY2PaBBQ7
1K Followers 250 FollowingOur team (@WashU and @VIB/UGent) focuses on phagocytosis of apoptotic cells, its elegant complexity, and relevance to homeostasis/disease