Here is an updated plot showing the remarkable similarity in the patterns of where spike mutations occur in the #SARSCoV2 variant BQ.1.1 versus the long terms hotspots of evolutionary change in human CoV-229E.
Here are a few slides that elaborate on this topic: slides.com/jbloom/sars2-v…
@jbloom_lab But the actual sites are somewhat different. Is this because of the differences in the spike structure?
@jbloom_lab Don't know what this means is this good news or not
@jbloom_lab You can generate this plot for all BA.2/4/5* diversity (among designated Pango lineages) by scrolling down to the entropy panel, selecting events: Unfortunately the x-axis is in nucleotides and not in AA coordinates next.nextstrain.org/staging/nextcl…
@jbloom_lab Or here, using entropy rather than events, which shows less common mutations more - and I'm now focusing on the more interesting S1 region