Now online, a study in collaboration with @LeopoldParts in which we asked how often natural variants can suppress deleterious mutations So what did we find? embopress.org/doi/full/10.15…
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First, we crossed ~1000 temperature-sensitive (TS) alleles into a bunch of genetically diverse wild yeast strains to isolate segregant haploid progeny that carried the TS allele.
@jsvanleeuwen @LeopoldParts Amazing work! Did you see any de novo suppressor mutations or were they all standing variation?