Lioba Berndt @liobanause
RA in Computational Psychiatry & Neuropharmacological Systems @UniofExeter • MSc Clinical Neuroscience @UCL • BSc Psychology @unipotsdam London, England Joined July 2023-
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Following411
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Lioba Berndt retweeted
Article: "A Canonical Microcircuit for Estimating Excitation/Inhibition (E/I) Balance" Coauthors on X: @HopeOloye, @liobanause biorxiv.org/content/10.110…
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Lioba Berndt retweeted
Testing an Active Inference agent in a 3D drone navigation task — it infers its own position and velocity from noisy observations, and selects actions by rolling out belief-based trajectories and minimizing expected free energy. #ActiveInference #BayesianLearning #AI #AGI
Lioba Berndt retweeted
🚨 New preprint! "Predictive Coding and Neurocomputational Psychiatry: A Mechanistic Framework for Understanding Mental Disorders" read it: doi.org/10.31234/osf.i…
Lioba Berndt retweeted
Some news... This week I passed my PhD viva with no corrections! A big thank you to my examiners @KathaSchmack and @magnetokrishio for such an inspiring discussion, and to my amazing supervisors @dr_rick_adams, @DanHauke and Karl Friston for all their support throughout my PhD!
Lioba Berndt retweeted
New preprint ! "Restoring Synaptic Balance in Schizophrenia: Insights from a thalamo-cortical conductance-based model." biorxiv.org/content/10.110… with @liobanause and @magnetokrishio.
Lioba Berndt retweeted
Delighted to hear that 5 of my protein designs have been selected for testing! Thanks @adaptyvbio - very excited to see the results
Delighted to hear that 5 of my protein designs have been selected for testing! Thanks @adaptyvbio - very excited to see the results
Lioba Berndt retweeted
Just submitted some designed proteins to @adaptyvbio EGFR binder competition. My strategy was Chai1 optimization on a diverse set of known EGFR binders shown below. Lower 2 are antibody FABs (necitumumab and panitumumab) which are too large for the competition requirements so...
Lioba Berndt retweeted
Imagine a dataset where it's the whole of the AlphaFold Database but you can pull-out the domain-like structures avoiding random spaghetti, or get all the domain-domain interactions, or check whether domains match a known structural super-family. That's TED:
Imagine a dataset where it's the whole of the AlphaFold Database but you can pull-out the domain-like structures avoiding random spaghetti, or get all the domain-domain interactions, or check whether domains match a known structural super-family. That's TED:
Lioba Berndt retweeted
TED: The Encyclopedia of Domains now published in @ScienceMagazine discovering and annotating 314 MILLION protein domains in the AlphaFold database. joint work of @CATH_Gene3D and @psipred here at UCL.
Lioba Berndt retweeted
Chai1 (open source version of AlphaFold3) installed in 5 mins and generates preds for this protein-protein + mol glue complex in 2 mins on a 3090. amazing.
Lioba Berndt retweeted
Our paper now published: Chainsaw predicts domains in protein structures. We combine this with homology detection to infer functional annotations for previously uncharacterised proteins in AlphaFold DB, we also... @nicolabordin @CATH_Gene3D @iansillitoe academic.oup.com/bioinformatics…
Lioba Berndt retweeted
The Encyclopedia of Domains identifies over 320M structural domains in the AlphaFold Database, including many not in CATH and other PDB-based databases. @nicolabordin @iansillitoe @_judewells @ShaunKandathil @psipred
Lioba Berndt retweeted
📣Excited to share my first first-author paper in @TrendsCognSci!📣 We ask - what does the brain find rewarding and why? @docqhuys @michaelbrowni19 and I provide a novel computational account of pleasure processes and pathways to anhedonia.🧵👇 sciencedirect.com/science/articl…
Lioba Berndt retweeted
Nature Neuroscience Regional, circuit and network heterogeneity of brain abnormalities in psychiatric disorders nature.com/articles/s4159…
Lioba Berndt retweeted
Ever wondered how closely #fMRI brain networks reflect a neural underpinning❓ We address this using simultaneous fMRI & widefield Ca²⁺ imaging in mice, and the answer is… complicated! 👉🧵[1/n] Jointly supervised by @EvelynMRLake & @PessoaBrain nature.com/articles/s4146…
Lioba Berndt retweeted
A Review in @ScienceTM looks at the complex connections between astrocytes and other types of cells in the nervous system, including neurons, oligodendrocytes, and microglia. Read more: scim.ag/5nb
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