Evan Macosko @macosko
Genomics technologist, Psychiatrist, Associate Professor, Massachusetts General Hospital @broadinstitute. Founder, Curio Bioscience macoskolab.com Joined May 2012-
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Evan Macosko retweeted
We developed an imaging-free spatial genomics technology where DNA barcodes diffuse to connect locally. Using UMAP, we reconstructed the physical locations of these barcodes, transforming spatial transcriptomics into purely molecular biology. biorxiv.org/content/10.110…
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Evan Macosko retweeted
How do genetic perturbations change cells? How are these effects shaped by cell type and dosage? How do we best extract insight from modern massive perturbation atlases? Im pleased to share a new preprint where we develop a suite of statistical approaches to these Qs (link below)
Evan Macosko retweeted
Hear us talk about Slide-tags!
Evan Macosko retweeted
I am thrilled to announce that I will be joining the Department of Genetics at Trinity College Dublin (@tcdgenmicro) in summer 2024! My lab will build and apply new tools to understand the formation and function of microglia states in brain health and disease.
Evan Macosko retweeted
Findings "strongly imply that there is no specific link between maternal mental illness or maternal infection during pregnancy" & neurodevelopmental disabilities (including autism) in offspring cambridge.org/core/journals/… free
Slide-tags unifies the single cell + spatial genomics worlds. It solves three key problems with existing spatial methods: 1) Cell segmentation (the biggest problem) 2) robustness and scalability (well-powered case-control studies now possible) 3) Multiomics (ATAC, RNA, etc)
Slide-tags unifies the single cell + spatial genomics worlds. It solves three key problems with existing spatial methods: 1) Cell segmentation (the biggest problem) 2) robustness and scalability (well-powered case-control studies now possible) 3) Multiomics (ATAC, RNA, etc)
Evan Macosko retweeted
Delighted to announce our work developing an approach to understand the function of human microglial states. @MartineTherrie4 and I will guide you through our work, a collaboration with @sasajereb from @macosko and @stevens1lab ! nature.com/articles/s4159…
Evan Macosko retweeted
Single-cell or spatial? Our new technology - Slide-tags - allows both in the same experiment, enabling true single-cell multi-modal spatial genomics ➡️ doi.org/10.1101/2023.0…
All single cell assays can now be spatial. Slide tags is simple, reliable single cell with hi-res spatial positioning. A truly outstanding scientific team: @insitubiology, @AndyRusss, @jacksonweir4, Naeem Nadaf. biorxiv.org/content/10.110…
Evan Macosko retweeted
Introducing Slide-tags: our new technology for truly single-cell, multi-modal spatial genomics! Had a blast working alongside @AndyRusss, @Naeemnadaff, @macosko, @insitubiology, and the rest of our team on this project! biorxiv.org/content/10.110… 1/9
Example uses of braincelldata.org: 1) label transfer your sc data to ours. Get cell type assignments and spatial positions. 2) Find genes or cell types enriched in a region. 3) Retrieve the minimal set of genes needed to define a cell type uniquely (ie for FISH).
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