Mike Mendelson @mikemendelson
Pediatric Preventive Cardiologist | Cardiac Molecular Epidemiology | 🇨🇦🇺🇸 Boston, MA Joined March 2009-
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Do you remember when you joined Twitter? I do! #MyTwitterAnniversary
You: There’s no ChatGPT use case in healthcare Docs: Watch this 👇
Do you remember when you joined Twitter? I do! #MyTwitterAnniversary
@LubertMD @CincyKidsHeart @ACHD_BioBank reporting on abnl lipids (↘️HDL, LDL) w/ #Fontan circulation. #ACHD #cardiotwitter @FontanOutcomes ahajournals.org/doi/full/10.11…
what's the role of lipids and lipoproteins in the development of atherosclerotic cardiovascular disease? An informative @JAMA_current clinical update. jamanetwork.com/journals/jama/…
Economic analysis suggests that cascade screening of ten year-old children for FH and initiation of treatment compared to usual case is cost saving. Via @ATHjournal sciencedirect.com/science/articl…
We (with Aviv Regev) want to share with you our preprint scPhere(biorxiv.org/content/10.110…), a deep generative model embedding of single-cell RNA-Seq profiles on hyperspheres and hyperbolic spaces @humancellatlas
New @ada_journals paper: Epigenome-Wide Association Study of Incident Type 2 Diabetes in a British Population: EPIC-Norfolk Study doi.org/10.2337/db18-0… #epigenetics #diabetes
A long #journey... begins! Proud to share our new paper @NatImmunol . @Marco_Di_Gioia & co. show how coincident recognition of #PAMP and #DAMP forges #immunometabolism and affects #atherosclerosis ! @Immunoscope @ImmunoMet @Immune_News @humanimmunenews nature.com/articles/s4159…
#Genetics is a powerful tool for understanding human #ageing New review article in @NatureRevGenet by Prof David Melzer & Dr Luigi Ferrucci that I am honoured to be part of doi.org/10.1038/s41576… Short thread below 1/5
What is Machine Learning? A Primer for the Epidemiologist written by @JustinLessler and colleagues at @JohnsHopkinsSPH . #epimethods @societyforepi @AmJEpi doi.org/10.1093/aje/kw…
A Sniderman et al masterpiece - Mass of cholesterol that will be deposited in artery is determined by the # of apoB particles that are trapped within intima. # of apoB particles that enter is determined primarily by the # of circulating apoB particles ow.ly/GtSO50wSzuD
So many thoughts about the ethical, social & legal implications of epigenetic aging/commerical testing after @mikemendelson’s talk at #CHRD2019 @CHRIManitoba
Thrilled to have @mikemendelson, @BostonChildrens #Pediatric Preventive Cardiologist and @UM_RadyFHS alumni, here at #CHRD2019 talking about #epigenetics and how they contribute to the intergenerational inheritance of #cardiometabolic disease in humans.
Holy moly: Search-and-replace genome editing without double-strand breaks or donor DNA from @broadinstitute David Liu & colleagues. Theoretically able to correct ~90% of human pathogenic variants: nature.com/articles/s4158…
In a registry-based cohort of the full Norwegian population, genetically-confirmed familial hypercholesterolemia is associated with ~8-fold risk of incident aortic stenosis jamanetwork.com/journals/jamac… @JAMACardio @TheFHFoundation
@ErinMichos @johnwmcevoy @rblument1 @HopkinsMedicine @NUIMerrionSq @NEJM And a 20-year study to show how vital it is to make the diagnosis and treat familial hypercholesterolemia early in life nejm.org/doi/full/10.10… @NEJM
This new study in @NEJM is amazing. Children with familial hypercholesterolemia treated with statins for 20 years just don't have cardiovascular events during young adulthood (unlike their affected parents). nejm.org/doi/full/10.10…
New study @NatureMedicine shows why we gain weight with age: We remove less fat as we age so if we don't eat less as we age, we gain weight btw, nuclear bombs made this study possible as they doubled atmospheric carbon-14 and as a result in our tissues nature.com/articles/s4159…

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