Li-Feng Jiang-Xie @neurobenjamin
Neuroscientist | Assistant Professor at Penn | Duke & NTU alum | Exploring brains—biological & artificial | We're hiring! med.upenn.edu/jiangxielab/ Philadelphia, PA Joined July 2014-
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Congratulations to everyone at Setpoint Medical, present and past, who worked for 18 years to bring a brand new idea for the first time into a clinical reality. This begins a new era for millions of patients needing new options. businesswire.com/news/home/2025…
Can synapses in the brain switch their signs between excitatory and inhibitory during learning🚦? Can they act more like weights in artificial neural networks, able to switch signs based on experience 🔃? Excited to share my thesis work in @blsabatini lab! 🧵 ⬇️ (1/13)
1/ 🚨 Our new paper is online in @Nature ! As its first author, I’m enthusiastic to finally share it with you all!🎉 🧠 We discovered a mechanistic link between cellular energy metabolism and the control of the need to sleep 💤 👉 nature.com/articles/s4158… @OxfordDPAG 🧵👇
It’s been a rewarding journey studying sleep as a postdoc, and I’m now exploring faculty positions in neuroscience. My latest work uncovers a neural circuit mechanism for homeostatic sleep. Open to opportunities and always happy to chat! 🔗 linkedin.com/in/sang-soo-le…
Our review, led by @SamanthaKeilPhD , providing a critical and up-to-date assessment of the role that glymphatic dysfunction plays in the development of clinical Alzheimer's disease, was published in @ScienceMagazine today: science.org/doi/full/10.11…
Our latest work is on the cover of @Nature (June 26, 2025)! Even more special: the stunning illustration was hand-drawn by first author Hao Sheng — a true scientist-artist.
Thank you Jonathan, Mina and Joe for having me on @Morning_Joe to discuss #TheGreatNerve!
Great progress here in this elegant work revealing new #vagus mechanisms as the basis for future therapeutics. @changsbrain
Great progress here in this elegant work revealing new #vagus mechanisms as the basis for future therapeutics. @changsbrain
Our new paper with Applied Cognition in @natBME . Using a wearable device that captures different determinants of glymphatic activity to define sleep-related features of glymphatic function in the human brain. nature.com/articles/s4155…
My lab at Penn is actively seeking motivated and creative Postdoctoral researchers to join our team. Candidates with strong experience in electrophysiology, imaging, proteomics, or molecular biology are especially encouraged to apply. med.upenn.edu/jiangxielab/
How does the brain work? Scientists are closer to the answer with the largest wiring diagram and functional map of a mammalian brain to date. 🧵
David Liu wins the Breakthrough Prize in Life Sciences for developing gene-editing technologies, including a "molecular word processor" that can find and replace whole sequences of DNA. His tools are already impacting diseases including cancer. breakthroughprize.org/News/91…
I'm really excited to introduce our new paper @DulacLab on the neurobiological original of "sociality" (the need of being together), recently published in Nature (see detailed digest below). nature.com/articles/s4158…
Thrilled to announce that my PhD work has been officially published in @Nature! nature.com/articles/s4158… 🧵🧵🧵🧵🧵🧵 1/8
AI provides a universal framework that leverages data and compute at scale to uncover higher-order patterns Today, @arcinstitute in collaboration with @nvidia releases Evo 2—a fully open source biological foundation model trained on genomes spanning the entire tree of life 🧵
I feel extremely honored to receive this award from @WashUNeurology. Very thankful for all the support from @jonykipnis and @kipnislab, and excited to start my lab at @PennMedicine. I am also looking forward to visiting WashU again soon!
I feel extremely honored to receive this award from @WashUNeurology. Very thankful for all the support from @jonykipnis and @kipnislab, and excited to start my lab at @PennMedicine. I am also looking forward to visiting WashU again soon!

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