ISPT_ProteinTermini @proteintermini
International Society of Protein Termini (ISPT), we have a shared interest in protein terminal modifications and their downstream effects on protein function. ispt.world worldwide Joined January 2019-
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Registration OPEN! EMBO Workshop on Protein termini | >30 confirmed speakers | Ribosome and translation | Nascent chain factors | PTMs | Protein degradation | N- and C-degrons | Oxygen sensing | Protein aggregation +++ | @EMBOevents meetings.embo.org/event/21-prote…
Novel human cell expression method reveals the role and prevalence of posttranslational modification in non-muscle tropomyosins ofc including N-terminal acetylation! Dominguez lab @PennMuscle @jbiolchem @proteintermini jbc.org/article/S0021-…
Expanding the N-Terminal Methylome by Repurposing of Proteomic Datasets. Still the little sister of N-terminal acetylation, but probably more common than originally anticipated. @thazbun @Purdue_MCMP @JProteomeRes @proteintermini pubs.acs.org/doi/10.1021/ac…
Of mice and men: mice harbor a gene encoding an alternative catalytic subunit of the major enzyme complex catalyzing protein N-terminal acetylation. Lessons learnt from mouse KO models. Great collab with Oh lab @GholsonLyon @MarmorsteinLab @proteintermini doi.org/10.7554/eLife.…
Cool finding! NatB-mediated N-terminal acetylation controls ACC oxidase levels and endogenous ethylene in Arabidopsis. Could be instrumental for potential applications 🤔🌱🌊@proteintermini @ISPA_Plants @CostRoxy link.springer.com/article/10.118…
Please help spreading! We are hiring a PhD-student to work on protein N-terminal acetylation and protein conformation. See jobs.vib.be/j/37086/phd-po….
Excellent resource of the ubiquitin-proteasome system and protein degradation in @MolecularCell. GID ubiquitin ligase revealed to target Thr N-termini in yeast! Congrats Khmelinskii @imbmainz Knop lab @ZmbhH Boone Andrews @DonnellyCentre @proteintermini cell.com/molecular-cell…
Congratulations to both @SjonHartman and @KayMoisan for jointly being awarded the Hugo de Vries prize for best plant-science PhD thesis in the Netherlands (2020)! Fantastic news 🎉
Congratulations to both @SjonHartman and @KayMoisan for jointly being awarded the Hugo de Vries prize for best plant-science PhD thesis in the Netherlands (2020)! Fantastic news 🎉
Most #crop plants are very sensitive to #flooding. Plant #PCOs control adaptive responses to flooding. #SupportingScience Structures of #Arabidopsis thaliana #oxygen-sensing plant cysteine oxidases 4 and 5 enable targeted manipulation of their activity pnas.org/content/early/…
Online Workshop: Protein N-terminal Processing and Proteolysis uib.no/en/rg/probe/14…
EMBO Workshop | Protein termini: From mechanisms to biological impact | 8–11 June 2022 | Bergen, Norway. 🇳🇴 It is a long wait, but stay tuned for an amazing speaker lineup! coming-soon.embo.org/w21-75 @EMBOevents @proteintermini @UiB
Molecular basis for cysteine oxidation by Plant Cysteine Oxidases from Arabidopsis thaliana #nendrule biorxiv.org/cgi/content/sh…
Protein N-terminal modifications matters - also for an N-terminal acetyltransferase. Proper maturation of NAA20's N-terminus is essential for the assembly of the NatB complex and downstream N-terminal acetylation in @JMolBiol. @proteintermini @CIMA_unav sciencedirect.com/science/articl…
N-terminal acetylation and myristoylation are essential for targeting GTPases to membranous compartments - @jbiolchem. Confirms and extends 2004 findings from Munro and Burd labs. A properly modified amphipathic helix is all it takes. @proteintermini jbc.org/cgi/content/lo…
One foot longer than the other. Novel pathogenic NAA10 variant specifically links NatA mediated N-terminal acetylation to hemihypertrophy @ejhg_journal Thx all contributors incl patients and families! @medofak_uib @HelseVest @uchealthnews @proteintermini rdcu.be/b7Fp0
Great to see @dr_mdwhite's Plant Cysteine Oxidase structures published - first clues to manipulating plant oxygen sensors. Great collaboration with @F_licausi, @McDonough_M and others: pnas.org/content/early/…
Fantastic to see what is most likely my final publication from my incredible post doc with @emily_flashman @OxfordChemistry out in PNAS! First crystal structures of the oxygen sensing PCOs. Great colab with @LauraDalleC @MikelLavi @s_iacopino @McDonough_M @Fra_LicO2si and more!
Fantastic to see what is most likely my final publication from my incredible post doc with @emily_flashman @OxfordChemistry out in PNAS! First crystal structures of the oxygen sensing PCOs. Great colab with @LauraDalleC @MikelLavi @s_iacopino @McDonough_M @Fra_LicO2si and more!
Now out in @eLife - by the Marmorstein lab @Penn @PennEpiInst. Molecular basis for N-terminal alpha-synuclein acetylation by human NatB. Activity of NatB (catalytic subunit NAA20, auxiliary subunit NAA25) inhibited by bisubstrate analog. @proteintermini doi.org/10.7554/eLife.…
New @TrendsBiochem review on the protein N-terminal acetyltransferases from the Marmorstein lab @PennEpiInst @Penn. Interested in structural biology or N-terminal acetylation - a major modifier of eukaryotic proteomes? Read it! @proteintermini sciencedirect.com/science/articl…
I really envy (in a +ve way) the camaraderie and collegiality of the N-term community in plants. You guys are such a great example & deserve a big 👏 #FridayThoughts #UKnowWhoUR
Dan Gibbs @DJ_Gibbs
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Frederica Theodoulou @freddietheodou1
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Daan @DaanWeits
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Rajat Kumar Jha @Rajat_Tweeets
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Journal of Molecular .. @JMolBiol
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Frederica Theodoulou @freddietheodou1
2K Followers 634 Following Plant sci prof. Proteostasis, transporters, hypoxia, baking. Serious about science but like to laugh. Own views. She/her.
Daan @DaanWeits
1K Followers 422 Following Assistant Professor at Utrecht University. I study the role that oxygen plays in plant development and abiotic stress.
Sjon Hartman @SjonHartman
3K Followers 1K Following Plant Biologist 🌱 Junior Professor of Plant Environmental Signalling & Development 🧬🔬 Studying Flooding Tolerance & Memory 🌊 at @UniFreiburg @CIBSS_UniFR
Emily Flashman @emily_flashman
657 Followers 227 Following Enzymes, oxygen and stress-sensing - mostly in plants
julia serres @jnbserres
2K Followers 141 Following
International Society.. @ISPLORE
900 Followers 219 Following International Research Community interested in Plant Responses to Hypoxia & Flooding.
Thomas Arnesen @NAT_machinery
808 Followers 726 Following Prof. Univ. of Bergen & Helse Bergen | Basic & translational science | Molecular Biology | Cancer | Endocrinology | Proteins | N-terminal acetylation
Rashmi Sasidharan @R_Sasidharan
2K Followers 1K Following Professor at Utrecht University | Plant abiotic stress signalling | Water 💧💧💧stress (Flooding, Drought) | Hypoxia | Stress recovery🌱🍂🌾
Francesco Licausi @Fra_LicO2si
2K Followers 619 Following Associate Professor of Plant Sciences, Department of Plant Sciences, University of Oxford, Uk
Anne Marie Labandera .. @annelab27
644 Followers 1K Following Researcher @UMREGFV @univbordeaux 🇫🇷 - Former Leverhulme & EMBO LT Fellow 🇬🇧 •PhD 🇨🇦 •BSc 🇺🇾 •Plant Cell Signalling/O2 sensing/flooding/Dormancy 🍇🌱
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418 Followers 222 Following Plant biologist at the University of Pisa and Sant'Anna. I like playing with synbio, playing the violin, and going to the beach at summer 🐙
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Muhammad Waqas Ali �.. @MuhammadAliUoB
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annibal_ms @AnnibalMs
332 Followers 390 Following Post doctoral, PhD Bioanalytical chemistry, #MaxPlanck Institute for Biology, love ski & hiking #Ageing #Metabolomics #Lipidomics #Celegans #massspectrometry
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Kai Fenzl @KaiFenzl
274 Followers 476 Following Postdoc in the Steinmetz lab @EMBL. Former PhD Student @ZmbhH, @BukauLab
Su Ran Mun @SuranMun
22 Followers 49 Following Ph.D. student Seoul National University, Biomedical Sciences. Interested in #Ndegronpathway #Proteostasis #autophagy #UPS #Targetedproteindegradation
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670 Followers 953 Following Author of the official novelization of Ys VIII: Lacrimosa of Dana
Plant Proteases 2022 @pp2020ljubljana
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IPS2019 @IPS2019
87 Followers 314 Following Official account of 11th General Meeting of the International Proteolysis Society ´Interfaces in Proteolysis´ - Mariánské lázně #IPS2019 @IntProtSoc
Ruth Geiss-Friedlande.. @Ruth_G_F
156 Followers 455 Following Biochemist and cell biologist. Fascinated by proteases and their roles both in protein degradation and regulation. Group leader
Kvido Strisovsky @KvidoStrisovsky
324 Followers 350 Following PI at @IOCBPrague, biochemist and molecular cell biologist, alumnus of @MRC_LMB, @EMBO_YIP, @CharlesUniPRG, @VSCHT, father of two, climber, outdoor enthusiast.
International Proteol.. @IntProtSoc
253 Followers 157 Following The International Proteolysis Society serves as a focus for scientists working on all aspects of proteolytic enzymes, their substrates, and inhibitors.
Plant Cell Physiology @PCP_EIC
8K Followers 3K Following Updates and news from Editor-in-Chief of Plant & Cell Physiology. PCP is published from Japanese Society of Plant Physiologists, since 1959.
Dirk Becker @DirkBecker64
404 Followers 515 Following Scientist at University of Würzburg. Plant Molecular Biology and Biophysics
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317 Followers 413 Following
Mass Spec Pro @massspecpro
4K Followers 753 Following Helping you stay on top of the mass spec landscape with news, articles, events, patents and more. Run by @mikegoodwin.
Molecular & Cellular .. @molcellprot
5K Followers 216 Following Molecular and Cellular Proteomics (MCP) | Research, perspective, technological innovation and resources, and issues in proteomics articles | Published by @ASBMB
In a newly accepted paper for #JIPB, Wang et al. explore the role of #ethylene and proteolytic N-degron pathway in the regulation of #Arabidopsis seed dormancy. #PlantSci #PlantDevelopment #hormones #GA #ABA doi.org/10.1111/jipb.1… @UofTCellSysBiol @Sorbonne_Univ_ @wileyplantsci
The F-box E3 ubiquitin ligase BAF1 mediates the degradation of the brassinosteroid-activated transcription factor BES1 through selective autophagy in Arabidopsis @IowaStateU @PingWan11721284 #PlantSci doi.org/10.1093/plcell…
Cytosolic Events in the Biogenesis of Mitochondrial Proteins sciencedirect.com/science/articl… Stress response to precursor accumulation 👇and much more, super unique figures, @yurabykoff
Congratulations, @ardemp! Very happy that @eLife recently published your and Joanne Chory’s paper on stretch-activated ion channels on carnivorous plants 🌱! elifesciences.org/articles/64250
2021 #NobelPrize laureate in physiology or medicine Ardem Patapoutian used pressure-sensitive cells to discover a novel class of sensors that respond to mechanical stimuli in the skin and internal organs.
Congratulations to all of the authors @fabienthery, @yfz_LPhenix, @VIB_PRC, @Svennetti, @VIBLifeSciences, @UIowaMicrobio! Our new and improved paper is now out at @NatureComms. nature.com/articles/s4146…
Happy to share (on behalf of our international team) our work in collaboration with Impens lab @VIB_PRC and @Svennetti that RNF213 a ubiquitin E3 that @GiselaOtten1 @FelixRandow recently showed to modify LPS can also be recruited to Listeria. biorxiv.org/cgi/content/sh… (1/4)
New Online #EPICXS Workshop on "Integrating #proteomics and #genomics technologies" organized by @scilifelab and @CRGenomica next 28th Oct 2021. Places are limited! Register today at: crg.eu/en/event/epic-…
Cellular and Protein Homeostasis Webinars: a reminder of today's talk by Jim Shorter (@ShorterLab @ShorterLabGroup )
Cellular and Protein Homeostasis Webinars Tuesday, October 5, 2021 ⌚️ 15:00 CEST James Shorter (The University of Pennsylvania ,🇺🇸) @ShorterLab @ShorterLabGroup "Countering deleterious phase transitions in ALS/FTD". Registration tinyurl.com/3mwkx5ra
Two exciting papers on iSCAT/mass photometry for imaging the dynamics of membrane-bound proteins out today from the Hundt and Schwille labs and Kukura lab along with an accompanying News and Views!! (papers in thread) N&V: nature.com/articles/s4159…
Hot off the press this October - the @PlantPhys Focus Issue on Sensors & Controllers academic.oup.com/plphys/issue/1… A must-read reference on genetically encoded biosensing and optogenetics approaches in plants And as the icing on the cake - look at this cover image by @jmugaldev
📗From Latest Issue: Mini Review from Special Issue on Mineral Transport Systems🛻🔀 Phosphate Uptake and Transport in Plants: An Elaborate Regulatory System🅿️🆙🌿🌱 doi.org/10.1093/pcp/pc… Yan Wang, Fei Wang, Hong Lu, Yu Liu, Chuanzao Mao🎊🎉
Fascinating new insight into the role of uORFs of mRNAs. Typically limiting translation of the 3’ main ORF, here the uORF-encoded peptide functions in signaling and cell proliferation. It regulates the activity of the kinase encoded by the mRNA. pnas.org/content/118/40…
The @SpoelLab strikes again: important news for #plant hormone signalling and #proteostasis
Proteasome-associated ubiquitin ligase relays target plant hormone-specific transcriptional activators biorxiv.org/cgi/content/sh… #bioRxiv
Novel human cell expression method reveals the role and prevalence of posttranslational modification in non-muscle tropomyosins ofc including N-terminal acetylation! Dominguez lab @PennMuscle @jbiolchem @proteintermini jbc.org/article/S0021-…
Modulating α-Synuclein Liquid–Liquid Phase Separation. Needless to say: N-terminal acetylation of α-Synuclein matters! By Maji lab @SamirKMaji1 and Roland Riek lab @ETH_en in @BiochemistryACS @proteintermini pubs.acs.org/doi/10.1021/ac…
Expanding the N-Terminal Methylome by Repurposing of Proteomic Datasets. Still the little sister of N-terminal acetylation, but probably more common than originally anticipated. @thazbun @Purdue_MCMP @JProteomeRes @proteintermini pubs.acs.org/doi/10.1021/ac…
Of mice and men: mice harbor a gene encoding an alternative catalytic subunit of the major enzyme complex catalyzing protein N-terminal acetylation. Lessons learnt from mouse KO models. Great collab with Oh lab @GholsonLyon @MarmorsteinLab @proteintermini doi.org/10.7554/eLife.…
A role of the N-degron pathway in obesity regulation? Sequencing of 640,000 exomes identifies rare protein-truncating variants in the E3 ligase UBR2 associated with more than twofold higher odds of obesity in heterozygous carriers. @proteintermini science.sciencemag.org/content/373/65…
Cool finding! NatB-mediated N-terminal acetylation controls ACC oxidase levels and endogenous ethylene in Arabidopsis. Could be instrumental for potential applications 🤔🌱🌊@proteintermini @ISPA_Plants @CostRoxy link.springer.com/article/10.118…
An interesting take on auxin transport (speaking as a lapsed transport biologist)…*stands back and waits for replies*
You have N-terminal modifications of histones, and then you have REAL N-terminal modifications of histones! You'll find them both here in this new review by @KirmizisLab in @EpigenChromatin. @proteintermini …eneticsandchromatin.biomedcentral.com/articles/10.11…
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