Alexander Röth @roethal
Joined January 2017-
Tweets178
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Following216
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📢 We are thrilled to announce that the 2nd edition of the #EBMT Handbook has been released, addressing the most recent developments and innovations in #HCT and #CellularTherapy 📖 Find out more and download your copy here ⬇️ ebmt.org/education/ebmt…
Neue orale Studientherapie (Substanz #Iptacopan) bei #PNH zeigt deutliche Verbesserung der klin. Befunde im Vergleich zur #Standardtherapie-Infusion. Studienleitung in Deutschland @roethal @F_Alashkar @UniklinikEssen @chr_reinhardt nejm.org/doi/full/10.10…
Iptacopan, an oral inhibitor of factor B, increased hemoglobin levels in patients with persistent anemia despite anti-C5 therapy and in patients without previous complement-inhibitor therapy. Read the full results of two phase 3 trials: nej.md/48QKlcU
A single dose led to complement pathway inhibition, control of hemolysis, and improvement in anemia, sustained over 15 weeks. ow.ly/awKX50QGPaz #redcellsironanderythropoiesis #clinicaltrialsandobservations
unser erstes Highlight des Jahres! Wir freuen uns auf den persönlichen Austausch zu ausgewählten Neuigkeiten und Ergebnissen der ASH-Jahrestagung 2023 i.R. unseres Hämatologie Seminars im UK- Essen, Deichmann-Auditorium. @chr_reinhardt @UniklinikEssen
Just out in Blood - Novel, long acting antibody for the treatment of #CAD: Safety, tolerability and activity of the active C1s antibody riliprubart in cold agglutinin disease: A Phase 1b study ashpublications.org/blood/article/… #ASH23 @HamatologieUk
Explore complement and targeted therapies at #ASH23! Join the Presidential Symposium today from 11-12:30 PT chaired by @DocsDock200 to hear @elenicelli, @roumenina, & Dr. Claudia Kemper reshape our understanding of complement-driven diseases. 🧵⬇️
Sutimlimab: Effektive Option zur Behandlung der Kälteagglutinin-Krankheit medical-tribune.de/medizin-und-fo…
SAVE THE DATE für #ASHtoday, die Berichterstattung aus San Diego ab dem 11. Dezember auf #medtoday. Sehen Sie sich am 11., 12. und 13. Dezember ab jeweils 8 Uhr die Videos zu 12 Themengebieten auf medtoday an und sammeln Sie Live-CME-Punkte. 💻 t1p.de/ua7xp
Save the date!👉 #Highlights der #ASH_Jahrestagung2023 bei uns am Mittwoch 10. 01. 2024, 17.00-20.00 Uhr, im Lehr-& Lernzentrum @UniklinikEssen Für das leibliche Wohl ist gesorgt, wir freuen uns auf viele Teilnehmende @MedEssen @chr_reinhardt @roethal
Just out: Fostamatinib for warm antibody autoimmune hemolytic anemia: Phase 3, randomized, double-blind, placebo-controlled, global study (FORWARD) @HamatologieUk @MedEssen American Journal of Hematology | Blood Research Journal | Wiley Online Library onlinelibrary.wiley.com/doi/10.1002/aj…
Excited for #ASH23 presidential symposium on complement Dec. 12,2023 @11am. @roumenina wll discuss the canonical complement cascade with an emphasis on defense against pathogens and host cell damage. Next @CKemperLab will discuss ...
Tag der schönen Meldungen @UniklinikEssen @NeuroEssen @MedEssen! Wirklich eine super Leistung unserer Med. Fakultät. Glückwunsch!
Nach dem Seminar ist vor dem Seminar: Wir freuen uns schon auf das 15. Patienten- und Angehörigenseminar PNH und AA am 21. September 2024 in Essen! @AAundPNHeV @lichterzellen @HamatologieUk @MedEssen @aamdsif @GlobalPnh @PNHSupport @pnhaacontact @PNHCanada
Endlich verfügbar: Nachlese unseres 14. Essener Patienten- und Angehörigenseminar #PNH und #AA mit den Vorträgen und Photos Dank der Unterstützung der @lichterzellen! @AAundPNHeV @HamatologieUk @MedEssen
1. Patientenseminar zur Sichelzellerkrankung in Essen: Jetzt sind alle Patient:innen wieder etwas schlauer. Tolle Veranstaltung! Vielen Dank!!! @F_Alashkar @HamatologieUk @MedEssen
In CARDINAL part B, upstream inhibition of the classical complement pathway in CAD maintained improved patient-reported outcomes at 2 years. loom.ly/fvw2TcQ #clinicaltrialsandobservations #redcellsironanderythropoiesis
Glückwunsch zum Posterpreis Klassische Hämatologie auf der DGHO @roethal @chr_reinhardt @UniklinikEssen
Bei einer so kleinen Indikation wie PNH (paroxysmale nächtliche Hämoglobinurie) gibt es soviele Substanzen in der Pipeline. Viel Forschung läuft. #hämatologie #iptacopan #dgho
Elodie Vallandingham @EVallandingh
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7K Followers 611 Following Revision aid for the FRCPath and RCPA haematology exams. We also do great haematology CPD for scientists, haematologists and pathologists🔬Ahemolytic PNH (white cell PNH): Clinical features and implications of a distinct phenotype of Paroxysmal Nocturnal Hemoglobinuria buff.ly/3Wd9MTb
Images that are repeated in the US. Israeli Americans replacing Palestinian flags with Israeli ones. #AmIsraelChai 🇮🇱🇺🇲🤍
This is my favorite coagulation cascade schematic courtesy of Dr. Carerra at UCSD. I am going to get this tattooed on my chest.
Nice paper from France in @BrJHaem on a series of relapsed / refractory T-LGL patients treated with Ruxolitinib. Some response observed in 86% though complete response in 14%. A potentially good option for patients going forward. onlinelibrary.wiley.com/doi/10.1111/bj…
Terrorist who stabbed 6 people to death ‘Known to police’ and targeted mother and her baby first. The attacker began the frenzied attack at 3:30 Sydney time- preying on a young mother pushing her 9 month old baby in a push chair first. Mother Ash Good, 38, died from her…
Perfectly planned takedown.
Neue orale Studientherapie (Substanz #Iptacopan) bei #PNH zeigt deutliche Verbesserung der klin. Befunde im Vergleich zur #Standardtherapie-Infusion. Studienleitung in Deutschland @roethal @F_Alashkar @UniklinikEssen @chr_reinhardt nejm.org/doi/full/10.10…
Overexcited for this achievement shedding new insights into PNH clinico-biological features👉”Paroxysmal nocturnal hemoglobinuria-related thrombosis in the era of novel therapies: a 2043 patient/years analysis” out in @BloodJournal @aamdsif
So satisfying to watch live the #ODAC meeting (at 4 AM Kyoto 🇯🇵 time where I am at #MDSsm meeting) & see vast majority of panel recognize the benefits over risks of #imetelstat based on our pivotal #IMerge trial, & look forward to having the drug approved for our patients!
@FDAOncology ODAC meetings can be gripping theater. (@MikkaelSekeres discusses this process in his book 'Drugs and the FDA'.) Lots of heated exchanges today. Final result: 12-2 vote in favor of imetelstat for #MDSsm $GERN. COI: I was 1st author on 2021 @JCO_ASCO report of Ph2.
@roethal strikes again! Big congratulations to our wonderful colleague and all involved! @HamatologieUk @UniklinikEssen @MedEssen @unidue
Iptacopan, an oral inhibitor of factor B, increased hemoglobin levels in patients with persistent anemia despite anti-C5 therapy and in patients without previous complement-inhibitor therapy. Read the full results of two phase 3 trials: nej.md/48QKlcU
Iptacopan, an oral inhibitor of factor B, increased hemoglobin levels in patients with persistent anemia despite anti-C5 therapy and in patients without previous complement-inhibitor therapy. Read the full results of two phase 3 trials: nej.md/48QKlcU
Pretransfusion hemoglobin level and mortality in adults with transfusion-dependent β-thalassemia ow.ly/zIVX50QNU1s #lettertoblood #clinicaltrialsandobservations #redcellsironanderythropoiesis #transfusionmedicine
COVID-19 vaccination response was not impaired in patients receiving treatment with sutimlimab for cold agglutinin disease. COVID-19 vaccines were well tolerated, and there were no signs of hemolytic exacerbations post-vaccination. onlinelibrary.wiley.com/doi/epdf/10.10…
Lets remember that there is a lot to be done yet!
The diagnosis of rare diseases and #PNH remains a major challenge, as the symptoms of PNH can vary greatly. On #RareDiseaseDay, we would therefore like to emphasise the importance of equal access to diagnosis and appropriate treatment for all those affected by rare diseases!
Guidelines for the Diagnosis and Management of Adult Aplastic Anaemia. buff.ly/3weB2FQ
A thank you to our 2023 clinical and statistical peer reviewers, who offered their time and expertise to help us make decisions on and improve papers thelancet.com/journals/lanha…
Daily oral iron supplementation increases iron losses that may reduce the efficacy of iron supplements. The amount of iron lost correlates with the amount of iron absorbed, not the dose of iron given. @AmbraGiorgetti buff.ly/3UJ4QER
A single dose led to complement pathway inhibition, control of hemolysis, and improvement in anemia, sustained over 15 weeks. ow.ly/awKX50QGPaz #redcellsironanderythropoiesis #clinicaltrialsandobservations
Seen in our ICU! Cannot love it more! Please retweet! #gitwitter #surgery #icu #meded #medical #medschool #pulmonary #critcare