Saif Khan @sfk_usc
Graduate student at @USC Joined November 2019-
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Saif Khan retweeted
Here's how to predict binding of tens or hundreds of small molecules to protein assemblies using Boltz 2 in ChimeraX. Accuracy depends on how similar the ligands and binding pockets are to existing experimental structures. rbvi.ucsf.edu/chimerax/data/…
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Saif Khan retweeted
Excited to present the result of a fantastic collaborative effort - funded by the National Institutes of Health, including the NIH HEAL Initiative, to develop safer analgesic drugs. nature.com/articles/s4158…
Saif Khan retweeted
Take a look at mini review from our end on opioid allosteric sites led by @Nokomis96 in Trends in Pharmacological Sciences @WashUClinPharm @WashUAnesRsrch @washumedicine
Saif Khan retweeted
A very exciting study from my postdoc work is hot off the press! With structural evidence, we demonstrate that inverse agonists can act via GPCR: G-protein complexes -offering new insights into GPCR biology. Thrilled to share this breakthrough!
A very exciting study from my postdoc work is hot off the press! With structural evidence, we demonstrate that inverse agonists can act via GPCR: G-protein complexes -offering new insights into GPCR biology. Thrilled to share this breakthrough!
Saif Khan retweeted
GPCR RENAISSANCE
GPCR RENAISSANCE https://t.co/v4CK78K9dA
Saif Khan retweeted
Beautiful work by the Gati group on kappa opioids where we played a small role. Good start to 2025. More big ones coming @Nokomis96 @WashUClinPharm @WashUAnesRsrch
Beautiful work by the Gati group on kappa opioids where we played a small role. Good start to 2025. More big ones coming @Nokomis96 @WashUClinPharm @WashUAnesRsrch
Saif Khan retweeted
Superb work! Simultaneous antagonist and G protein bound GPCRs!! Loads to understand still! Congrats @CorneliusGati and team! nature.com/articles/s4158…
We did some cool science!! Preprint is out 👇
We did some cool science!! Preprint is out 👇
Saif Khan retweeted
Cool
Saif Khan retweeted
An opioid with a literal, light-sensitive 'on/off switch' to avoid fatal side effects, that works in vivo? Look no further - Azomorphine-3 (AM3)! The most exciting study I've been part of, thus far. With @sevakat1 @DirkTrauner and Josh Levitz lab. biorxiv.org/content/10.110…
Saif Khan retweeted
Introducing a new class of potent opioid analgesics that remain in the periphery (hence no respiratory depression) and can be locally activated with light (hence no constipation). As efficacy switches, they also provide insight into how opioids can switch from weak to strong…
Saif Khan retweeted
It's happening! We're excited to be hosting ~300 attendees for the 9th SoCal CryoEM Symposium @USC tomorrow. @USCDornsife @USCBridge dornsife.usc.edu/bridge-institu…
Saif Khan retweeted
Join Amgen Structural Biology in Thousand Oaks to do #cryoEM ! amgen.wd1.myworkdayjobs.com/en-US/Careers/…
Saif Khan retweeted
Our lab at the Univ of Maryland has an NIH-funded #postdoc vacancy to investigate the structural basis of #SARSCoV2 hijacking of host trafficking #proteins. We use #cryoem, #Crystallography, & #OctetBLI. And #Rockville is an aewsome place. @UMD_IBBR @UMBaltimore @ChemBiochemUMD
Saif Khan retweeted
Save the date and please share: We're excited to be hosting this year's SoCal CryoEM Symposium @USC, Friday, October 11th in Los Angeles. More details to follow. @cryoEM_Papers @USCBridge @USCDornsife @USCMann
Saif Khan retweeted
Here's a wonderful write-up by the @USCDornsife communications team, about our recent @CellCellPress paper. @USC @USCBridge dornsife.usc.edu/news/stories/c…
Saif Khan retweeted
Thrilled to present our manuscript out today in @CellCellPress. A tour-de-force on anaphylatoxin complement receptors - 9 (!!!) unique GPCR structures: C3aR/C5aR1, biased/partial/full agonist, Go/Gq, mouse/human. doi.org/10.1016/j.cell…
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