Pancreatic cancer #immunotherapy #DataScience resource: scRNAseq & scTCRseq on a total of 80,000 T cells from 57 cancer samples & 22 normals. Reference atlas for transcriptional profiles, organization & differentiation trajectory of T cell immunity in pancreatic cancer. 🧵👇
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--Background-- Pancreatic ductal adenocarcinoma (PDAC) is the most commonly diagnosed form of pancreatic cancer (85%). It is also its most lethal form, with a staggering 5-year survival rate of only 9%. PDAC is the fourth-highest cause of cancer-related death in United States.