Lim Kai Shi @smol_nerd_boy
Trying to make sense of the truth. Just documenting my life as a wet-dry lab hybrid neurogenetic scientist and a start-up founder. Joined June 2025-
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One thing that took me a long time to grasp is the difference between narrow-sense heritability (h2) and SNP heritability (h2g), and why performing the same estimation method on related samples gets you the former, but on unrelated samples, it gets you the latter. Here’s why: 🧵
Rushing in a fast paced world seems like too mainstream, how about we take a slower steps and sprint when everyone gets tired. Sounds like a plan huh? 🤨
A striking example of human genetics-driven molecular discovery. A GWAS of Yersinia pestis infection in 1,000 B cell lines identified a missense variant (rs2282284) in FCRL3—a B cell membrane protein—strongly associated with protection against infection. It turns out that FCRL3…
Pangenome-aware DeepVariant biorxiv.org/content/10.110… 🧬🖥️🧪 github.com/google/deepvar…
Regulatory features aid interpretation of 3′UTR variants by @LindsayRomo3 et al. hubs.li/Q03njm0Q0 Collection highlight from @AJHGNews (@GeneticsSociety)
In this study, the authors take a panoramic look at how polygenic risk score (PRS) performance for major common diseases has evolved over the past 15 years. While GWAS sample sizes have steadily grown year after year, the gains in PRS accuracy showed strong early momentum but…
A powerful alternative to principal components (PC) to account for population structure in genetic association analysis: spectral components (SPc) Compared to PC, SPc - explain more variation in population structure with fewer components (90% for SPc vs 50% for PC) - more…
Excited to share our preprint, describing a method for heritability partitioning with GWAS sumstats that significantly improves upon S-LDSC Led by the fantastic Hui Li, and co-supervised by @XihongLin #ASHG24 poster 4089F medrxiv.org/content/10.110…
My study involves GWAS for Parkinson’s disease but I kinda focus too much in solving individuals ancestry (due to multi ancestry nature of my data). Does it really worth my time for that tho? (eg: PCA followed by supervised Admixture)
The Japan Vibes that I still can’t move on
Mapping out carefully each individual’s ancestry carefully🗺️
Personalis, Inc. @PersonalisInc
3K Followers 1K Following Personalizing Precision Oncology #PrecisionOncology | #ImmunoOncology | #ImmunoGenomics | #Biomarkers | #TumorMicroenvironment | #Exome | #Transcriptome
Michael Snyder, PhD @SnyderShot
7K Followers 51 Following Professor of Genetics Director, Center of Genomics & Pers Med CoFounder: https://t.co/Pbp5i17rWN https://t.co/psJ9Ar6KiC https://t.co/X9PoQJP2Bo, https://t.co/qIDxcXFRj6 https://t.co/STxFxTdObZ
Tobi Alegbe @Tobioinformatic
384 Followers 658 Following Single-cell data scientist @OpenTargets with @emblEBI. Previously PhD student @Cambridge_Uni/@SangerInstitute I look at small things on a big scale
Open Targets @OpenTargets
5K Followers 2K Following Public-private partnership using human genetics and genomics data for systematic drug target identification and prioritisation We're on Bluesky @opentargets.org
Min Seo Kim, MD, MSDH @MinSeoKim_MD
3K Followers 2K Following Physician-scientist | Postdoc @MGHMedicine @BroadInstitute of MIT and Harvard | Genomics/Omics/Artificial intelligence | Former Public Health Official
Kian Sadeghi @KianSadeghi5
12K Followers 477 Following Founder, CEO @NucleusGenomics | IVF built for genetic optimization | @zfellows @thielfellowship
Dave Font @davefontenot
20K Followers 7K Following 🏯 building the residency for repeat founders @HF0 🚀 early backer ramp, optimism, pave, https://t.co/jvjGUzHCCT, https://t.co/UrZdMVRDO2 and more...
NHGRI-EBI GWAS Catalo... @GWASCatalog
5K Followers 119 Following Human Genome-wide Association Studies Problems: [email protected] Submission: https://t.co/2HjFpd73C9 Citation: https://t.co/5BqufB89k0 Also LinkedIn/Bluesky
Patrick Hsu @pdhsu
45K Followers 3K Following co-founder @ArcInstitute, @BerkeleyBioE professor | researcher & investor in genome editing, biotech, AI | 🇨🇦 @harvard @broadinstitute @editasmed, Fast Grants
Arc Institute @arcinstitute
37K Followers 57 Following A new scientific institution for curiosity-driven biomedical science and technology.
Veera Rajagopal @doctorveera
19K Followers 4K Following 🇮🇳 MBBS, MD, 🇩🇰 PhD | 🧬 Scientist @ 🇺🇸 Regeneron | Translating genetic insights into life-saving medicines | thoughts @ https://t.co/dTItNQy2BX
Sasha Gusev @SashaGusevPosts
20K Followers 3K Following Statistical geneticist | Associate Prof at @DanaFarber / @harvardmed / @DFCIPopSci | Blogging at https://t.co/4D7UObBNdd
Jack Kosmicki @jakphd
1K Followers 118 Following Statistical geneticist @ Regeneron | PhD @broadinstitute & @harvardmed | tweets are my own
Ming "Tommy" Tang @tangming2005
41K Followers 2K Following Director of bioinformatics at AstraZeneca. YouTube at chatomics. On my way to helping 1 million people learn bioinformatics. Also talks about leadership.
GenomeWeb @GenomeWeb
24K Followers 586 Following Highlighting the best of GenomeWeb's coverage of the genomics sector. Maintained by Bernadette Toner, CEO.
ASHG @GeneticsSociety
52K Followers 309 Following The American Society of Human Genetics (ASHG) is the world's largest professional membership organization for human genetics & genomics specialists.
UCSC Genome Browser @GenomeBrowser
19K Followers 76 Following The UCSC Genome Browser is a public, freely available, open-source web-based graphical viewer for the display of genome sequences and their annotations.
Genomics Education @genomicsedu
22K Followers 2K Following NHS England's Genomics Education Programme. Providing knowledge, skills and experience in #genomics #NHSgms #genomes100K #NHS #GenomicsConversation
Front Line Genomics @FLGenomics
12K Followers 4K Following Join us in uniting the Genomics community! Our goal is to deliver the benefits of genomics to patients faster
Samuel Hume @DrSamuelBHume
29K Followers 1K Following I’m a resident doctor, I write about progress in medicine
Dr. Dominic Ng @DrDominicNg
11K Followers 1K Following I write about Genetics, AI, and the Brain | Physician | PhD Candidate in Genetics | Anne Rowling Clinic | UK Dementia Research Institute
Nature Reviews Geneti... @NatureRevGenet
93K Followers 1 Following Publishing reviews and commentaries across the fields of genetics and genomics. Part of @SpringerNature and @NaturePortfolio.
Nature Genetics @NatureGenet
128K Followers 1K Following Nature Genetics is a monthly journal publishing high impact research in genetics and genomics. RT/like=interesting/relevant, not necessarily endorsement.
Apple Hub @theapplehub
1.3M Followers 162 Following The latest Apple news. Not affiliated with Apple Inc.
Massimo @Rainmaker1973
3.1M Followers 150 Following Engineer. Selecting and curating pictures and videos trying to awaken your sense of wonder. Science, tech, art, weather, space, the unusual around us.
Interesting As Fuck @interesting_aIl
2.3M Followers 113 Following Posting interesting history, tech, art, and more.Trends for United States
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