VIGNESH P @vignesh_pgi
Associate Professor (Pediatrics), Ped. Allergy Immunology Unit, PGIMER, Chandigarh, India pgimer.edu.in Chandigarh Joined July 2011-
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VIGNESH P retweeted
Happy to share our recent paper!
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VIGNESH P retweeted
New Perspective article from @TimothyBuckey and Jennifer Heimall @ChildrensPhila describes the #ethical #dilemmas encountered by #clinical #immunologists in the evaluation of an inborn error of immunity. hubs.la/Q03BNtN40 #InbornErrorsOfImmunity
VIGNESH P retweeted
New in @JExpMed: Fu et al. identify biallelic germline ASXL1 variants as the cause of a novel #InbornErrorOfImmunity, linking ASXL1 deficiency to epigenetic dysregulation, combined immune deficiency, chronic viral infections, & malignancy hubs.la/Q03zN5pk0
VIGNESH P retweeted
STAT1-GOF is characterized by infections & #autoimmunity. In @jhumimmunity, Buddingh, Schuetz et al. report overall survival after allogeneic #HSCT in an international cohort of 36 patients is 72.2%, markedly improved from an earlier report. hubs.la/Q03zBrMb0
VIGNESH P retweeted
Staines-Boone, Blancas-Galicia, and colleagues characterize a new genetic predisposition to coccidiodomycosis. Autosomal dominant STAT1 deficiency is a monogenic defect that increases susceptibility to coccidioidomycosis in humans. hubs.la/Q03zlsqz0 #InbornErrorsOfImmunity
VIGNESH P retweeted
1/ We are delighted to share our work published in @SciImmunolgyidentifying the role of LY9 in CD4+ T cell IFN-γ immunity to Mycobacterium tuberculosis (science.org/doi/10.1126/sc…)
VIGNESH P retweeted
Here’s the latest from Hsieh Lab! Can we link tissue-specific spatially resolved immune molecular, cellular, and histopathology profiles to specific immune pathway defects? From biopsy to precision medicine? #theissueisinthetissue doi.org/10.1002/art.43…
VIGNESH P retweeted
A fascinating Review about inborn errors of immunity in Rheumatology !
A fascinating Review about inborn errors of immunity in Rheumatology !
VIGNESH P retweeted
Inborn errors of immunity: Manifestation, treatment, and outcome—an ESID registry 1994–2024 report on 30,628 patients rupress.org/jhi/article/1/…
VIGNESH P retweeted
Every dollar invested in #primaryhealthcare yields up to 10$ in economic growth. Expenditure on health (especially public health & primary care) must be seen as an investment and not a spend.
Every dollar invested in #primaryhealthcare yields up to 10$ in economic growth. Expenditure on health (especially public health & primary care) must be seen as an investment and not a spend.
VIGNESH P retweeted
@jhumimmunity's July issue is here! hubs.la/Q03vJ9Qp0 The cover image shows MHC class I–mediated antigen processing and presentation. From Gadolae et al. (hubs.la/Q03vJcff0) reviewing #InbornErrorsOfImmunity affecting the MHC class I pathway for antigen presentation.
VIGNESH P retweeted
Prompt diagnosis of severe combined immunodeficiency is critical. A study explores variable factors including the impact of newborn screening associated with hematopoietic stem cell transplantation outcomes and overall survival in a multiethnic cohort. bit.ly/4402HJ4
VIGNESH P retweeted
Impact of BFM90 based CT on immune reconstitution Check out our full article published in IJHBT 👉🏻 link.springer.com/article/10.100… For full pdf rdcu.be/eufiZ 🧬 Key Findings: •📉 B-cell depletion: >35% had undetectable B cells by maintenance; suppression persisted…
VIGNESH P retweeted
ICYMI: Our Clinical #Immunology Collection feattures recent and exciting advances in the field of translational immunology – novel discoveries in #autoimmunity, tumor immunology, ocular- and #neuroinflammation, #immunodeficiency & human disease genetics 👉 hubs.la/Q03kK8480
VIGNESH P retweeted
➡️Whole-genome sequencing of 2,762 Indians has unravelled the layers of ancestry, high intermixing with Neanderthals and Denisovans. This along with high endogamy in India could potentially result in harmful mutations in some groups. sciencechronicle.in/2025/06/28/a-g…
VIGNESH P retweeted
A must-read for anyone interested in human B lymphocytes, their physiology and pathology !
A must-read for anyone interested in human B lymphocytes, their physiology and pathology !
VIGNESH P retweeted
Inhibition of lysosomal degradation increases ADA2 expression. Congrats @immunophilia and the rest of my team and all contributors. Thank you @FWOVlaanderen @ERC_Research for the support. pubmed.ncbi.nlm.nih.gov/40545182/
VIGNESH P retweeted
Super excited about our recent paper describing a high throughput screen for functional variants in the context of APDS. Rare disease ain’t always that rare! Great collaboration with Ben Izar and Dusan Bogunovic! cell.com/cell/abstract/…
VIGNESH P retweeted
This review by @DonaldVinh highlights the diversity in intrinsic fungal susceptibility across individuals and populations, through genetic- and autoantibody-mediated processes. hubs.la/Q03kDJ-v0 📘 In our Clinical #Immunology Collection: hubs.la/Q03kFj_p0 #FOCIS2025
VIGNESH P retweeted
Successful coil occlusion of intracranial aneurysm in a child with STAT3 hyper IgE syndrome. New study from Archan Sil, Pandiarajan Vignesh and colleagues (PGIMER, Chandigarh, India): hubs.la/Q03qGvKC0 #InbornErrorsOfImmunity
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