Yuri Deigin @ydeigin
Drug developer of Alzheimer’s/CNS gene therapies https://t.co/HPgKP0qGJv | Vitalist & longevity maximalist | DRASTIC cofounder https://t.co/jpRBlDRMg1 |🇺🇦🇨🇦 linkedin.com/in/yurideigin/ Toronto, Canada Joined November 2010-
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4 years after my first Medium article on Covid origins, I wrote another one. In it, I make the case that SARS-CoV-2 is precisely the virus WIV was hunting for in 2019. yurideigin.medium.com/sars-cov-2-is-… Below is a thread on the key points:
Wow, Ralph Baric is on a roll destroying anti-lab leak main talking points.
Wow, Ralph Baric is on a roll destroying anti-lab leak main talking points.
Exactly! At the @COVIDSelect hearing yesterday, Dazsak repeated his mantra several times that "EcoHealth's work is critical to preventing the next pandemic" and yet, not only did EcoHealth fail to prevent the SARS2 pandemic — that started on the doorstep on their key collaborator…
Exactly! At the @COVIDSelect hearing yesterday, Dazsak repeated his mantra several times that "EcoHealth's work is critical to preventing the next pandemic" and yet, not only did EcoHealth fail to prevent the SARS2 pandemic — that started on the doorstep on their key collaborator… https://t.co/rVmP8pIwka
Alina Chan @Ayjchan
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Baric's quotes dovetail with @ydeigin's title, "SARS-CoV-2 is precisely the virus WIV was hunting for in 2019". Imo, albeit circumstantial, this is strong evidence that (1) Covid had a lab-related origin; and (2) deep down, that's also what Baric thinks. yurideigin.medium.com/sars-cov-2-is-…
Ok, finally, below is weak circumstantial evidence of a research-related leak. DEFUSE is not a blueprint for making SARS2 but one of its authors, Ralph Baric, the world's leading coronavirologist, answering subcommittee questions in a "most complete & truthful manner possible"…
❗ Q: "Do you know if the WIV had access to additional backbones or unpublished full-length virus" Baric: "I'm sure they were working on other full-length molecular clones"
The dangerous thing is not just gain of function, but the whole enterprise of collecting pathogens from remote places to probe them in leaky labs in the name of pandemic prevention. It likely caused a pandemic. Has it prevented anything?
U.S. taxpayer dollars should NEVER be used to fund dangerous gain-of-function research. Still, prior to COVID-19, @EcoHealthNYC President Peter Daszak facilitated gain-of-function research in Wuhan, China on the taxpayer's dime. This week, Dr. Daszak will be held accountable.
1/ Baric on DEFUSE: "We were fundamentally interested in why sarbecoviruses didn't have a furin cleavage site" (P 193-194) 🙂This "fundamental" question turned out to have an amazingly simple answer... @ydeigin @mitch_benzine
@ydeigin @COVIDSelect We need more clarifications of that unpublished Nov-2018 "data dump". Did it include sequences from samples collected in the period 2016-2018? e.g. from these sites? x.com/franciscodeasi…
So, a bat sampling trip to Yunnan in August 2017 was omitted in EHA Year 4 Report (FOIA @fastlerner). Btw, why no mention to US grants in the 'Acknowledgments' section of this article? [More to come]
@ydeigin They also hace cell lines from Mojiang x.com/franciscodeasi…
[Thread] Bat tissue collection and cell lines from the 3rd trip to Tongguan (TG) mine in Mojiang in Apr-2013
@tgof137 @ydeigin @franciscodeasis Precedent is big in say law, but science? Experiments need at least some novelty. You draw targets around the new stuff, then say because those parts are new, the whole thing would not happen. Might work with many papers.
What's most worrisome to me is why no one but Yuri Deigin is spending time pointing this out. Certainly a coronavirologist somewhere in the world has a skosh of curiosity about having somebody look into this. But no.
Covid origin really comes down to which of the following is more likely: 1) The Wuhan Institute of Virology found the kind of SARS-like virus it set out to look for in late 2018 (with a “highly variable” spike that is 10-25% different from SARS1 but still able to enter human…
@ydeigin And that no trace of the virus was ever found anywhere along the 1000 miles route it had to take from Yunnan to Wuhan. Funny how such a highly infectious virus only decided to infect people once it arrived in Wuhan.
Thanks @ydeigin Folks, it really is this simple a choice to think about.
Covid origin really comes down to which of the following is more likely: 1) The Wuhan Institute of Virology found the kind of SARS-like virus it set out to look for in late 2018 (with a “highly variable” spike that is 10-25% different from SARS1 but still able to enter human…
@ydeigin @tgof137 @franciscodeasis Zoonati: Obscure upstream events led to an uncertain number of SC2 spillovers in a wet market from an unknown intermediate host. Also Zoonati: What? You find a lab origin plausible? What's the experimental rationale & molecular mechanism underlying SC2's furin cleavage site?
No-one serious believes the WIV just stopped collecting SARSr-CoVs in 2015
In a textbook case of mistaking absence of evidence for evidence of absence, Peter claims that because WIV didn't publish a SARS2 progenitor before the pandemic, they must not have had one. It's an odd line of reasoning to take on Covid origins, because if we would have had…
wearing many hats is one of the fun (and hard) aspects of building a startup and then taking them off one by one as the company grows is a really incredible feeling
@JTLonsdale The whole thing was like a Scooby Doo episode- Shaggy standing in front with back to of Wuhan Lab. “I just can’t figure out where the virus came from Scoob “ “Raggy rook…. Right rere right rere” “Nah scoob viruses don’t come from virus labs… they come from eating bats in…
@emilyakopp Your work has been phenomenal, thank you. Geographic coincidence is striking. But another under-appreciated coincidence is temporal coincidence. Of all the thousands of years mankind has been encountering wildlife, why 2019? Is it just a coincidence the outbreak was just a few…
The extreme similarities b/w the virus DEFUSE applicants applied in 2018 to create and the SARS2 virus which appeared the following year in Wuhan cannot logically be a coincidence. Excellent new piece by @ydeigin w/ important insights re #COVID19 origins. yurideigin.medium.com/sars-cov-2-is-…
excellent summary on SARS2 related strains, WIV sampling and FCS design by @ydeigin! yurideigin.medium.com/sars-cov-2-is-… The only part I disagree with is the closing statement: "while we do not yet have certainty in any particular Covid origin scenario". Here, I'm with @R_H_Ebright👇
@ydeigin 1/ As you point out, the 2015 Baric-Shi work on MERS-HKU4 (and similar work by Whittaker et al) led them to realize that spike cleavage is at least as important as receptor binding, *at least for MERS-like viruses*. But it's puzzling that the 2005 Nunberg et al paper...
People ask: What are the chances SARS-CoV-2 emerged near a lab specializing in SARS-like viruses? A more precise question might be: What are the chances SARS-CoV-2 emerged near the lab looking for SARS 2.0?
4 years after my first Medium article on Covid origins, I wrote another one. In it, I make the case that SARS-CoV-2 is precisely the virus WIV was hunting for in 2019. yurideigin.medium.com/sars-cov-2-is-… Below is a thread on the key points:
@ydeigin Fascinating thread. I think Baric's interest in SARSr-CoVs with 10-25% divergence in spike goes back to 2015 or earlier. And he has referred to the upper limits ("highly variable") as "book-ends", for instance in his briefing to Congress in early 2020.
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