ypradat @ypradat
Postdoctoral researcher. Translational Research, Applied Mathematics, Computational Biology, Oncology. @GustaveRoussy @PrismCenter @FondationARC Paris Joined November 2019-
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Just left #MAP2024 with inspiring talks x current hot topics in oncology! I was very pleased to cross path again with @PapaemmanuilLab and to attend with colleagues S. Dogan, @FAndreMD, @Elsa2Bernard from @GustaveRoussy. Many thanks to @FondationARC for the travel grant.
I am thrilled to announce that I will be supported by a postdoctoral fellowship from @FondationARC for the next 3y to investigate the molecular features of treatment-related myeloid leukemias. Work under the supervision of @Elsa2Bernard at @GustaveRoussy and part of @PrismCenter.
1st award @myESMO : I Ray-Coquard on rare gyne cancers. How to improve outcome: precise dg (referral), quality of network (infrastructure & scient collab), guidelines adh, inclusion of all stakeholders, database, biomarker driven approvals. @PrismCenter cited ! #ESMO2023
The DAISY trial of T-DXd in MBC with variable HER2 expression is out on @NatureMedicine. Many important findings, including a similar ORR with T-DXd in HER2-low (37.5%) & HER2-0 (29.7%) MBC. Congrats to @FerMosele @FAndreMD et al for this impressive work! nature.com/articles/s4159…
Very proud to see our work on the pan-cancer comparison of the genomic landscapes of primary and metastatic tumor published in this weeks issue of Nature: nature.com/articles/s4158…. @fran_mj88 @arne_van_hoeck @HartwigMedical @UMCU_CMM @oncodeinstitute @VHIO
.@PrismCenter selected to receive 30-40 M euros to build a Precision Oncology Center. Vision: to classify pts based on biology. Scientific strategy: bottom-up approach to model cancer biology in each pt (fig 2) for early cancer or relapse detection, & tt optimisation (fig 3).
We financially and technically supported a pan-TCGA WES analysis in the @CD_AACR paper "Integrative #Pancancer Genomic and Transcriptomic Analyses of Refractory #Metastatic Cancer" by @ypradat, @DGautheret, @snikolae et al. aacrjournals.org/cancerdiscover… @PrismCenter @GustaveRoussy
Now presenting metaPRISM. Come and visit us @AACR poster section 31. @GustaveRoussy @UnivParisSaclay
#Statistics thought of the day: futility of much high-dimensional omics research (false discovery rates be damned): when N<p there is often no correlation between estimated and actual effects hbiostat.org/bbr/hdata.html…
Integrative #Pancancer Genomic and Transcriptomic Analyses of Refractory #Metastatic Cancer, by @ypradat, @DGautheret, @snikolae et al. bit.ly/3Yq5XaL @PrismCenter @GustaveRoussy @centralesupelec @ParisSaclay @Inserm
Now online in @CD_AACR: Integrative Pan-cancer Genomic and Transcriptomic Analyses of Refractory #Metastatic Cancer - by @ypradat @DGautheret Sergey Nikolaev and colleagues @PrismCenter @GustaveRoussy @centralesupelec @ParisSaclay @Inserm aacrjournals.org/cancerdiscover…
📯 Hear ye! Hear ye! The #TopTweet is presented to thee! 🥂 Congratulations to the team with Drs. Yanis Tazi (@TaziYanis) and Ellie Papaemmanuil (@PapaemmanuilLab) from @MSKCancerCenter on the development of an open-access clinical decision support tool!
📯 Hear ye! Hear ye! The #TopTweet is presented to thee! 🥂 Congratulations to the team with Drs. Yanis Tazi (@TaziYanis) and Ellie Papaemmanuil (@PapaemmanuilLab) from @MSKCancerCenter on the development of an open-access clinical decision support tool!
👉META-PRISM: 1,031 pan-cancer refractory metastatic tumors profiled via whole-exome and transcriptome sequencing. medrxiv.org/content/10.110…
Tks anirban ! RNA seq and whole exome in 1000 and 500 pretreated metastatic cancers. Interesting to see the impact of prior therapies, especially platinum, on DNA + discovery of new alterations involved in resistance (PTEN transloc). A huge work from PRISM (maybe futur center🤞)
Tks anirban ! RNA seq and whole exome in 1000 and 500 pretreated metastatic cancers. Interesting to see the impact of prior therapies, especially platinum, on DNA + discovery of new alterations involved in resistance (PTEN transloc). A huge work from PRISM (maybe futur center🤞)
WES & RNAseq landscape of > 1,000 multi-resistant tumors treated @GustaveRoussy highlights the current gap in understanding treatment resistances. Preprint medrxiv.org/cgi/content/sh…. Data will be made available upon release in peer-reviewed journal. @centralesupelec @PrismCenter.
4 yrs ago, we discussed with Mathematicians @centralesupelec about integrating Maths in Cancer Research projects. It’s nice to see papers coming on Mathematical models of cancer from our teams. Here a modeling of myeloproliferative disorders 👇 pnas.org/doi/10.1073/pn…
Proud to have been part of this fantastic study and of Papaemmanuil's team! This work contributes to improving our understanding of highly-aggressive AML tumors and hopefully will help medical doctors better assess the risk profile of each patient.
Proud to have been part of this fantastic study and of Papaemmanuil's team! This work contributes to improving our understanding of highly-aggressive AML tumors and hopefully will help medical doctors better assess the risk profile of each patient.
Very pleased and honored to have had the opportunity to present the first results of our study on META-PRISM, a cohort of > 1,000 very aggressive metastatic tumors. Thanks to @GustaveRoussy, @PrismCenter & @centralesupelec for making this possible. #ESHG2022

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