Bhandoola_Lab @Bhandoola_Lab

As a lab, we're all in. Joined February 2024

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Bhandoola_Lab @Bhandoola_Lab

a year ago

Our colleagues will of course decide whether the new NK classification proposed by @EricVivier1 is useful. What their decision, I do think a classification that makes sense of both mouse and NK subsets would be very useful to the field.

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Bhandoola_Lab @Bhandoola_Lab

a year ago

Our contribution was to show that mouse NK cells develop by 2 pathways, and that the transcriptional signatures that defined these 2 mouse NK subsets also distinguished human NK subsets defined by CD56.

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Bhandoola_Lab @Bhandoola_Lab

a year ago

Glad to have contributed to the work by Rebuffet, @EricVivier1 and colleagues, reposted below.

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Nature Immunology @NatImmunol

a year ago

Vivier and colleagues integrated scRNA-seq and CITE-seq data to provide a resource of human NK cell heterogeneity in healthy tissues and in the tumor setting. Read it here: rdcu.be/dM61D nature.com/articles/s4159…

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Bhandoola_Lab @Bhandoola_Lab

a year ago

And here are the links to the two new papers in Nature Immunology. From us and our collaborators @SimonGrassmann, @SunLab_Official, @BelkaidLab nature.com/articles/s4159… From the lab of Bendelac and McDonald: nature.com/articles/s4159…

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Bhandoola_Lab @Bhandoola_Lab

a year ago

And here is the thoughtful N&V from Emma Patey & @bjorkstrom_lab nature.com/articles/s4159…

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Bhandoola_Lab @Bhandoola_Lab

a year ago

Such a bittersweet surprise to be back to back in Nature Immunology with Albert. To my thinking, our two papers are very complementary.

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Bhandoola_Lab @Bhandoola_Lab

a year ago

The original papers are here, one from our lab, one from the lab of Albert Bendelac. rdcu.be/dKS3i rdcu.be/dKS9d

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ImmuNoah'sArk @immunonoah

a year ago

Great summary from Emma Patey & @bjorkstrom_lab about the 2 recent papers studying NK cell developmental origins from the late Bendelac's lab & the Bhandoola's lab: nature.com/articles/s4159… ILCs with more nuance! Orginal studies: rdcu.be/dKS3i rdcu.be/dKS9d

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Nature Immunology @NatImmunol

a year ago

Bhandoola and colleagues describe the existence of two developmental pathways that give rise to functionally distinct NK cell subsets. Read it here: rdcu.be/dKPp7 nature.com/articles/s4159…

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Bhandoola_Lab @Bhandoola_Lab

a year ago

The CCR media team has a succinct outline of this latest work from our lab:

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Immunity @ImmunityCP

a year ago

Online now: Transcription factor Tox2 is required for metabolic adaptation and tissue residency of ILC3 in the gut dlvr.it/T63Tgk

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Bhandoola_Lab @Bhandoola_Lab

a year ago

science.org/doi/full/10.11… Other recent work from our lab. Stay tuned for more.

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Bhandoola_Lab @Bhandoola_Lab

2 years ago

And here's the link to the paper itself, below. nature.com/articles/s4158…

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Bhandoola_Lab @Bhandoola_Lab

2 years ago

Bone marrow plasma cells require P2RX4 to sense extracellular ATP rdcu.be/dyDzS The link is to a web-readable version of our lab's first paper on plasma cells. From a very fun collaboration between our lab at the National Cancer Institute and David Allman's lab at Penn.