Burstein lab @BursteinLab
Having fun with microbial genomic and machine learning @TelAvivUni tau.ac.il/~davidbur Israel Joined September 2022-
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Applications for the 2024-25 Azrieli Int’l #Postdoctoral #Fellowship are OPEN! Apply by Nov 15 to be considered for a postdoc position at a top academic institution in Israel – available to candidates worldwide. Learn more: bit.ly/3YSBmV7 #CallforApplications
We recently discovered lateral transduction (LT). Now, we unveil the 4th mechanism of transduction: lateral cotransduction. This system involves SaPIs and is more powerful and versatile than phage-mediated LT. Great fun with @JchenLab and @jrossfitz cell.com/cell/fulltext/…
After a fascinating first edition in Israel in 2023, the symposium on the immune systems of bacteria is back. April 16-18 2024 in Boston. Save the date!
After a fascinating first edition in Israel in 2023, the symposium on the immune systems of bacteria is back. April 16-18 2024 in Boston. Save the date!
I am thrilled🤗to announce our latest work on phage-plasmids (P-Ps) together with @epcrocha Here available 👇 doi.org/10.1101/2023.0… and perfect for vacation reading too😅 P-Ps facilitate gene flow between phages and plasmids by being at their genetic interface. 1/n
🚀Genetic testing in #space? CRISPR-based genetic diagnostics was successfully tested in microgravity on the @Space_Station 🛰️Read Dr. @GurPines , @BursteinLab , Dr. @KarinMittelman and the Ph.D. student @danalon6 's new paper shorturl.at/ivwFZ
We have 2 openings for faculty positions: one in microbiology and the other in biotechnology! en-lifesci.m.tau.ac.il/sbcr/news/facu…
New preprint about genome editing in ladybugs! biorxiv.org/content/10.110… CRISPR/Cas9 is an excellent tool for genome editing. It makes things much more straightforward than previous technologies.
Thrilled to have played a small role in this fascinating project by the brilliant @SternLab! They analyzed > 11M viral genomes to detect chronic infections and investigate their potential contribution to the evolution of novel SARS-CoV-2 variants. Read more 👇
Thrilled to have played a small role in this fascinating project by the brilliant @SternLab! They analyzed > 11M viral genomes to detect chronic infections and investigate their potential contribution to the evolution of novel SARS-CoV-2 variants. Read more 👇
Could not resist. Making that figure in 2019, I thought the newly uncovered diversity of antiphage systems was already incredible. We now know it was just the tip of the iceberg. I hope our new review will help people dive into this wonderful field. rdcu.be/dg3ql.
This was such a fun and exciting project!!!
My PhD advisor, Prof. Guido Sessa, passed away this morning after a rattling week. He was a mentor to his core. He never ceased to support his students. He did so quietly, without them knowing. He shaped me into the scientist I am today. He gave me freedom to pursue my ideas. 1/4
Did you enjoy @crispr2023 or want to come to the next one! The #crispr conference will be in @Christchurch_NZ organised by @PeterFineran, @dsashital @gavinjknott and @drbridgetwatson. Check out the website crispr2025.org
Excited for the next talk @bageco2023 by @rafapinilla92 on novel anti-CRISPR genes of plasmids and phages!
Brilliant talk @rafapinilla92 on #phages #CRISPR #anticrispr #racrs 🏃🏃♀️🏃 amazing results from a super collaborative project - 🗣️ @SarahCamara94 and David Mayo Muñoz - exactly as we dream science to be 🤩
Open group leader position in #prokaryote #phylogenetics! Join our vibrant community of evolutionary biologists in @_K_E_C. Inquiries during #SMBE2023 are welcome (to T. Dagan). @CRC1182 @trans_evo @kieluni details here: tinyurl.com/4266uyve
Did you know cGAS isn't alone in its mission? It's part of a large family of innate immune sensors that sense distinct PAMPs, produce varied nucleotide signals, and control complex signaling networks! 🧵Check out our latest story on cGAS-like receptors: cell.com/cell/fulltext/…
Thrilled to share my 1st last author paper! 🎉 We reveal type IV-A3 CRISPR-Cas’ secrets: epic inter-plasmid battles via gene silencing & unique memory acquisition! 🧬💥 AND, we built a potent tool for re-sensitizing bacteria to antibiotics! 💊 Link: biorxiv.org/content/10.110…
So proud of my team for our latest work, led by researcher Mark Katz. Featuring 12 new anti-CRISPRs, ones that clearly evolved from cas genes, and one that is a super broad spectrum inhibitor. Check it out: biorxiv.org/content/10.110…
New preprint from the lab: How horizontal transfer drives subsequent adaptive mutations in core genes. With an application to quinolone resistance. biorxiv.org/content/10.110…
Aude Bernheim @AudeBer
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4K Followers 344 Following Biochemist, structural biologist, CRISPR enthusiastDoes mRNA get acetylated? Reanalyzing a dataset claiming that it does (Arango et al, Mol. Cell, 2022), we cannot find evidence supporting acetylation. Instead we find compelling evidence for major technical issue leading to miscalling of sites. sciencedirect.com/science/articl…
I want to close with a big shoutout to @JosephGeorgeso2, from the lab, who led this reanalysis. Chasing down positive results is fun. Chasing down negative ones requires endurance. Kudos Joe for the persistence!
To promote a diverse pool of speakers/reviewers (etc), we introduced at SISB2024 a list of PIs in bacterial immunity searchable by career stage, country and gender. Inspired by @GaetanBurgio. Mail me to add your name or correct mistakes! docs.google.com/spreadsheets/d…
Our new paper with the @Gogarten_Lab, led by Israela Turgeman-Grott, is finally out and shows some surprising properties of homing endonucleases within archaeal double inteins. tinyurl.com/4ruey3mv #Haloferax #archaea #inteins #meganucleases
Every single word. 🇮🇱🇮🇱🇮🇱
Greetings in Israel have gone fully Bayesian: Q: "How are you, given ...?" A: "I'm ok, given ...". All day, every day
1/15 Thrilled to share our newest work in @Nature! Viruses block CRISPR-Cas immunity using small RNA anti-CRISPRs, a.k.a “Racrs” 😎 nature.com/articles/s4158…
1/3 Excited to share our work published in @Nature! We uncover how phages inhibit CRISPR-Cas immunity via RNA anti-CRISPRs (𝗥𝗮𝗰𝗿𝘀)! nature.com/articles/s4158…
Thrilled to see our latest work published this week, on the essential roles of IscB/TnpB -- ancestral homologs of Cas9/Cas12 -- in transposon maintenance & spread. A wonderful team effort led by the talented Chance Meers! Thread on bioRxiv version below... nature.com/articles/s4158…
Great news - our lab's latest manuscript is out on bioRxiv! Led by postdoc Chance Meers, we discovered that RNA-guided DNA cleavage by transposon-encoded nucleases arose to facilitate the pervasive spread and inheritance of transposons. 🧵: (1/6) biorxiv.org/content/10.110…
Paper alert !📜🚨📢 Rotem's paper is out in @CellReports just in time for your Yom Kippur binge reading: "Silc1 long noncoding RNA is an immediate-early gene promoting efficient memory formation". See tweetorial of the preprint for most details. 1/2 cell.com/cell-reports/f…
New preprint! 🎇📜 Rotem's work on the roles of Silc1 lncRNA in the CNS 🧠, where we find it regulates its cis-buddy Sox11 and is required for efficient 🐭 spatial memory formation. A 🧵: biorxiv.org/content/10.110…
Excited to share preprint looking at viral defense systems in Asgard archaea! It reveals their roles in the origin of immunity in eukaryotes. Led by @Leao_pel w/ @katy_appler @val_deanda @em_aguilarpine @KathrynPCurrie1 a thread... biorxiv.org/content/10.110…
Honored and humbled to receive the Max Planck Humboldt Research Award for 2023. Thank you to the Humboldt Foundation and the Max Planck Society for this honor! Excited towards collaborating with @JoergLab at @Helmholtz_HIRI and @v_hornung in LMU Munich mpg.de/20827644/max-p…
Glückwunsch an den Mikrobiologen Rotem Sorek zum Max-Planck-Humboldt-Forschungspreis 2023! 👏🎉 Die Max-Planck-Humboldt-Medaillen erhalten Amy Buck und Kandice Tanner. @maxplanckpress @SorekLab @WeizmannScience humboldt-foundation.de/entdecken/news…
Applications for the 2024-25 Azrieli Int’l #Postdoctoral #Fellowship are OPEN! Apply by Nov 15 to be considered for a postdoc position at a top academic institution in Israel – available to candidates worldwide. Learn more: bit.ly/3YSBmV7 #CallforApplications
Proudly watched @SarahCamara94 defend her PhD thesis! She absolutely smashed it!🔥Her dedication and hard work serve as an inspiration to all!! 🎓🥂
@rafapinilla92 Thank you Rafa 🫶 absolute dream team! 🦄🦩Thank you for your endless support and supervision throughout the years! Supervisor of the year ⭐️ couldn’t have wished for anyone better!
🌟 It’s a match! F-like plasmids select their partner prior to conjugation via TraN, which acts as a sensor, determining the plasmid host range 🔓💘🔒 #Plasmid #Conjugation #PlasmidLove academic.oup.com/nar/advance-ar…
We recently discovered lateral transduction (LT). Now, we unveil the 4th mechanism of transduction: lateral cotransduction. This system involves SaPIs and is more powerful and versatile than phage-mediated LT. Great fun with @JchenLab and @jrossfitz cell.com/cell/fulltext/…
Last postdoc work by the great @UGene2020 who is now off for a much deserved tenure track position @INRAE_MICALIS . This completes a triplet of studies on the nature, contribution, and evolution of phage-plasmids in Bacteria.
I am thrilled🤗to announce our latest work on phage-plasmids (P-Ps) together with @epcrocha Here available 👇 doi.org/10.1101/2023.0… and perfect for vacation reading too😅 P-Ps facilitate gene flow between phages and plasmids by being at their genetic interface. 1/n
I can't wait for the 2024 symposium on the "beyond CRISPR" immune system of bacteria, which will take place in Boston on April 16-18, 2024. Save the date!