Why did 2.3.4.4b clade #H5N1 need a long stalk N1, unlike the previous clades H5N1s?
We identified the emergence of 2.3.4.4b #H5 HA with a distinct #glycosylation pattern in its RBD that drove its preferential pairing with long stalk N1 and the emergence of this novel variant.
Why did 2.3.4.4b clade #H5N1 need a long stalk N1, unlike the previous clades H5N1s?
We identified the emergence of 2.3.4.4b #H5 HA with a distinct #glycosylation pattern in its RBD that drove its preferential pairing with long stalk N1 and the emergence of this novel variant.
How do bats tolerate deadly viruses without severe disease?
In our latest review, we uncover the fascinating immune adaptations that help bats regulate inflammation and cell death—allowing them to host viruses like SARS-CoV, Nipah, and Ebola.
Read the full article here 🔽
How do bats tolerate deadly viruses without severe disease?
In our latest review, we uncover the fascinating immune adaptations that help bats regulate inflammation and cell death—allowing them to host viruses like SARS-CoV, Nipah, and Ebola.
Read the full article here 🔽
Pleased to share our recent review article on the emerging biology of Z-nucleic acids (Z-RNA/Z-DNA) and their sensing by #ZBP1 in virus infections, cellular physiology and disease pathogenesis.
Great work by @SanchitaMishr20 &AyushiAminDey.
onlinelibrary.wiley.com/doi/full/10.11…
So Happy to share our lab's latest study, Uncovering how RNA viruses modulate viral RHIM proteins in bats and humans, resulting in activation of different cell death pathways 🦇🧬🦠. Congratulations to the team.@keshu_VRimmCh@SanchitaMishr20@Disha__dakcell.com/iscience/fullt…
Reservoir host species (birds and bats) often stay asymptomatic compared to humans during viral infections. Regulation of multimodal cell death pathway (PANoptosis) in bats and birds contributes to their viral tolerance. #Anantika@keshu_VRimmChmdpi.com/1999-4915/16/1…
2K Followers 2K FollowingProfessor and CSL Centenary Fellow and NHMRC Leadership Fellow at @JCSMR, The Australian National University @ouranu | Inflammation | Infection | Cancer
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44 Followers 254 FollowingResearch student, Ravi Muddashetty Lab, Center for Brain Research.
Studying neuronal functioning and dysregulation in Alzheimer's Disease.
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657 Followers 415 FollowingWe study how neurons handle proteins aggregates and dysfunctional organelles and apply these principles to understand Neurodegeneration.
44 Followers 254 FollowingResearch student, Ravi Muddashetty Lab, Center for Brain Research.
Studying neuronal functioning and dysregulation in Alzheimer's Disease.
IISc graduate
41K Followers 2K FollowingDirector of bioinformatics at AstraZeneca. YouTube at chatomics. On my way to helping 1 million people learn bioinformatics. Also talks about leadership.
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47K Followers 2K FollowingBren Professor of Computational Biology @caltech. Blog at https://t.co/FFQzhEsmhi. Tweets represent my views, not my employer's. #methodsmatter
2K Followers 2K FollowingProfessor and CSL Centenary Fellow and NHMRC Leadership Fellow at @JCSMR, The Australian National University @ouranu | Inflammation | Infection | Cancer
11K Followers 7K FollowingResearch lab of Dr. Stephen Waggoner. Opinions expressed are Dr. Waggoner's alone and not on behalf of lab staff or employer.
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6K Followers 160 FollowingAsa and Patricia Springer Professor of Structural Biology @ Harvard Medical School and Boston Children’s Hospital. #immunology #structure_biology
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2K Followers 793 FollowingAsst Professor at #Biochemistry, Indian Institute of Science #IISc. Interested in Zoonotic & H5Nx viruses, Bats/Birds, Z-RNAs, Inflammasomes & Cell death
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