Subham Das @_Subham_Das
PhD student @IISc Bangalore. Interest lies in 🦇#Cell death & Immunology. Bengaluru, India Joined October 2022-
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Do we know whether non-human mammals enable the human adaptation of 2.3.4.4b #H5N1 to establish human infections? Excited to share our study, published now, addressing this question. #AvianInfluenza @iiscbangalore @RanjanaNataraj @avinashkarkada journals.asm.org/doi/10.1128/sp…
Why does RNA undergo glycosylation? Excited to have our new paper out. We in collab w/ Ryan Flynn show N-glycans on glycoRNAs hide self-RNA from endosomal TLRs promoting ‘silent’ clearance of dead cells. nature.com/articles/s4158… @uconnhealth @UConnResearch
🚨Second study from the lab. @CellReports SARS-CoV- and SARS-CoV-2-like viruses are found in insectivorous bats, but the antiviral responses in these bats remain less studied. Here we show how bat cells respond to SARS-CoV-2 and shed light on virus entry. cell.com/cell-reports/f…
Glad to have Kaushal visiting our Dept. Superb talk and interesting insights of bat immunity and zoonotic viruses. @BICS_IISc @sci_questions
Glad to have Kaushal visiting our Dept. Superb talk and interesting insights of bat immunity and zoonotic viruses. @BICS_IISc @sci_questions https://t.co/GpY1tA7cBw
Great work by Garg et al. in "Identifying a role of RGG-peptide in disassembling mutant FUS and TDP43 condensates implicated in ALS, projecting their possible therapeutic role in treating ALS." biorxiv.org/content/10.110… @LabRajyaguru @keshu_VRimmCh #ALS #neurodegeneration
🦇 🦇 Bat viral RHIMs: Viral mimicry gone rogue.!!! 🦠 Check out this interesting interview of @SanchitaMishr20 from my group by @biopatrika. A lot to know about how bats promote pathogenic trait evolution in RNA viruses.! 🦇 @iiscbangalore @BICS_IISc
🦇 🦇 Bat viral RHIMs: Viral mimicry gone rogue.!!! 🦠 Check out this interesting interview of @SanchitaMishr20 from my group by @biopatrika. A lot to know about how bats promote pathogenic trait evolution in RNA viruses.! 🦇 @iiscbangalore @BICS_IISc
Why did 2.3.4.4b clade #H5N1 need a long stalk N1, unlike the previous clades H5N1s? We identified the emergence of 2.3.4.4b #H5 HA with a distinct #glycosylation pattern in its RBD that drove its preferential pairing with long stalk N1 and the emergence of this novel variant.
Why did 2.3.4.4b clade #H5N1 need a long stalk N1, unlike the previous clades H5N1s? We identified the emergence of 2.3.4.4b #H5 HA with a distinct #glycosylation pattern in its RBD that drove its preferential pairing with long stalk N1 and the emergence of this novel variant.
🚨In this study, we generated primary lung organoids and used them to derive monolayers and air-liquid interface (ALI) cultures to compare the replication kinetics of two highly pathogenic coronaviruses, SARS-CoV-2 and MERS-CoV. #LZCI #LIBI biorxiv.org/content/10.110…
We showed some time back 2.3.4.4b #H5N1 shows long stalk (full length) N1 (NA) in birds and mammals, unlike previous H5 clades , which preferentially paired with N1 with stalk deletions (short stalk). Glad to see another study with similar observations biorxiv.org/content/10.110…
We showed some time back 2.3.4.4b #H5N1 shows long stalk (full length) N1 (NA) in birds and mammals, unlike previous H5 clades , which preferentially paired with N1 with stalk deletions (short stalk). Glad to see another study with similar observations biorxiv.org/content/10.110…
How does inflammatory cell death reveal insights about Bat viral tolerance? 🦇 🦇 Check out our interesting discussion. @sci_questions @BICS_IISc @iiscbangalore
How does inflammatory cell death reveal insights about Bat viral tolerance? 🦇 🦇 Check out our interesting discussion. @sci_questions @BICS_IISc @iiscbangalore
Kickstart your year with insights into #innateimmunity and #inflammasome biology! Register for the #InflammaZoom, our free monthly webinar series. Next session: January 20 at 8.00am GMT w/ @keshu_VRimmCh -@iiscbangalore & @mere_conjecture - @UTAS_ bit.ly/3DP7H8W
So Happy to share our lab's latest study, Uncovering how RNA viruses modulate viral RHIM proteins in bats and humans, resulting in activation of different cell death pathways 🦇🧬🦠. Congratulations to the team.@keshu_VRimmCh @SanchitaMishr20 @Disha__dak cell.com/iscience/fullt…
Reservoir host species (birds and bats) often stay asymptomatic compared to humans during viral infections. Regulation of multimodal cell death pathway (PANoptosis) in bats and birds contributes to their viral tolerance. #Anantika @keshu_VRimmCh mdpi.com/1999-4915/16/1…
Non-human mammalian adaptive signatures of 2.3.4.4b H5N1 have clues for possible human adaptations. @keshu_VRimmCh @RanjanaNataraj biorxiv.org/content/10.110…
Check out this much needed insights on ongoing H5N1 outbreak from our Dept faculty, virologist @keshu_VRimmCh in Cell Leading Edge article along with experts in this field. "H5N1 influenza: Urgent questions and directions"! shorturl.at/wples
Check out this much needed insights on ongoing H5N1 outbreak from our Dept faculty, virologist @keshu_VRimmCh in Cell Leading Edge article along with experts in this field. "H5N1 influenza: Urgent questions and directions"! shorturl.at/wples
Now online! H5N1 influenza: Urgent questions and directions dlvr.it/TBZmD1
A Green and Bright Day at @iiscbangalore Our lab picture at IISc.!! Our group is interested in investigating the Emergence of Pandemic viruses, Reservoir host Biology, Z-RNA sensing and Cell Death. @BICS_IISc
Our new work attempting 2 important questions: Why did 2.3.4.4b clade #H5N1 emerge as a highly pathogenic panzootic virus, which has not been achieved by previous viruses? Is the pairing of avian influenza HA and NA stochastic or molecularly programmed? biorxiv.org/content/10.110…
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