Cian McCarthy @CianPMcCarthy
Cardiologist @MGHHeartHealth | Former IM Resident @MGHMedicine & CV fellow @MGHCVFELLOWS | Alum: @UCC | Irish ☘️ | Opinions are my own Boston Joined December 2017-
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Cian McCarthy retweeted
AQUATIC In pts with CAD (>6 months after stent) and AF, OAC alone resulted in less major bleeding and less MACE/CV death than OAC and aspirin, with a NNH of 46 patients, contributing to evidence for the OAC alone strategy for chronic CAD and AF nejm.org/doi/full/10.10…
Cian McCarthy retweeted
A couple more important studies at #ESCCongress2025 1/4
Cian McCarthy retweeted
2️⃣ Obicetrapib and Cardiovascular Outcomes x.com/JACCJournals/s… x.com/ProfKausikRay/… BROADWAY NEJM x.com/NEJM/status/19… PREVAIL REBMBRANDT: Obicetrapib+ ezetimibe x.com/CianPMcCarthy/…
2️⃣ Obicetrapib and Cardiovascular Outcomes x.com/JACCJournals/s… x.com/ProfKausikRay/… BROADWAY NEJM x.com/NEJM/status/19… PREVAIL REBMBRANDT: Obicetrapib+ ezetimibe x.com/CianPMcCarthy/…
Cian McCarthy retweeted
DAPA ACT HF TIMI 68 negative trial on inpatient SGLT2i initiation (possibly due to short 2 month follow up and low event rate) but totality of data from EMPULSE, SOLOIST WHF, and DAPA ACT HF TIMI 68 shows significant benefit (incl mortality) to inpatient initiation of SGLT2i 2/4
Cian McCarthy retweeted
Conflicting data from REBOOT and BETAMI-DANBLOCK regarding use of beta blockers after MI in preserved LVEF (both published in NEJM), however meta-analysis of trials of mildly reduced LVEF 40-49% shows consistent benefit to beta blockers in this population 4/4
Cian McCarthy retweeted
MAPLE-HCM shows Aficamten monotherapy superior to metoprolol monotherapy in symptomatic oHCM patients in improving exercise capacity, symptoms, LVOT gradient, NT proBNP. Could support a paradigm shift to myosin inhibitors as initial therapy for LVOTO? 3/4
Cian McCarthy retweeted
Other highlights from #ESCCongress2025 1/4
Cian McCarthy retweeted
Some important updates to the 2019 ESC Dyslipidemia guideline #ESC2025 1/5
Cian McCarthy retweeted
BP 139/89 = “normal” BP 140/90 = “disease” Same with cholesterol. These binary thresholds are outdated & misleading jacc.org/doi/10.1016/j.… #JACC #Hypertension #Cholesterol #CVD @johnwmcevoy
Cian McCarthy retweeted
In this Viewpoint, @CianPMcCarthy and colleagues advocate for cardiovascular disease outcome trials for new BP lowering treatments targeting novel pathways. ja.ma/4lsA64L @CianPMcCarthy @johnwmcevoy
Implementing the 2025 Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: Leveraging Evidence to Push the Boundaries of Clinical Care | Hypertension ahajournals.org/doi/10.1161/HY…
Cian McCarthy retweeted
Blood pressure (BP) guidelines moved the bar lower for hypertension treatment, among other changes in the first national guideline update since 2017. Read more at: medpagetoday.com/cardiology/hyp…
Cian McCarthy retweeted
Amazing to see this new set of guidelines out with advances including earlier treatment, focus on sex-specific BP risk before, during, and after pregnancy, and PREVENT risk for total CVD (ASCVD+HF) >=7.5%. Kudos to the leadership team, AHA/ACC, and JCCPG staff @NMCardioVasc
Amazing to see this new set of guidelines out with advances including earlier treatment, focus on sex-specific BP risk before, during, and after pregnancy, and PREVENT risk for total CVD (ASCVD+HF) >=7.5%. Kudos to the leadership team, AHA/ACC, and JCCPG staff @NMCardioVasc
Cian McCarthy retweeted
🚨 Excited to share our new manuscript in @CircAHA led by @BellomoTiffany and team. We evaluated lipoprotein(a) as a prognostic marker for extracoronary atherosclerotic vascular disease progression in @uk_biobank. 👉 doi.org/10.1161/CIRCUL… 🧵1/6
Cian McCarthy retweeted
For symptomatic patients who’ve undergone CCTA, added knowledge gleaned from AI-CPA (@Heartflow) changes the management strategy more than half the time, according to new data from the DECIDE registry. tctmd.com/news/ai-based-… @CianPMcCarthy @SuzanneJBaron #SCCT2025
Thank you so much @AnasAAlani ! Grateful to @Cleerlyhealth for sponsoring this award and @Heartflow for funding this study. It was an honor to accept this award on behalf of the DECIDE investigators @lesleejshaw @RonBlankstein
Thank you so much @AnasAAlani ! Grateful to @Cleerlyhealth for sponsoring this award and @Heartflow for funding this study. It was an honor to accept this award on behalf of the DECIDE investigators @lesleejshaw @RonBlankstein
Cian McCarthy retweeted
SCCT is proud to announce the 2025 CTRA winner - Dr. @CianPMcCarthy - for his groundbreaking work on AI in atherosclerotic plaque management! Learn more: ow.ly/EBIP50Wilxi
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