Creative Biostructure @CreBiostructure
We specialize in offering solutions for academia and biotech/pharmaceutical industries in the fields of structural biology and membrane protein technologies. creative-biostructure.com Ramsey Road, Shirley, NY Joined November 2015-
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Cryo-EM SPA turns noisy micrographs into near-atomic models—if your data pipeline delivers. Our new article covers motion correction, CTF, particle picking, 2D/3D classification, ab initio + refinement, heterogeneity, and tools like RELION/Scipion. creative-biostructure.com/resource-cryo-… #CryoEM
CRAF is one of three RAF-family kinases and is mutated in cancer and RASopathies. The authors report structural and mechanistic studies of CRAF/MEK1/14-3-3 complexes that explain distinct features of CRAF regulation. nature.com/articles/s4146…
AI + Cryo-EM = Faster, smarter, more accurate structural biology. 🔬🤖 From particle picking to 3D reconstruction, AI is transforming cryo-EM data analysis—accelerating discoveries in #DrugDiscovery & #MolecularBiology. 🔗 Read more: creative-biostructure.com/resource-artif… #CryoEM #AI
Using cryo-electron microscopy, the interactions of Sestrin2 and CASTOR1 with GATOR2 were resolved, revealing how mTORC1 activation is regulated and how nutrient availability triggers signalling for cellular growth. nature.com/articles/s4158…
From the protein-folding puzzle 🧩 to near-experimental precision 🎯 — AlphaFold has transformed #StructuralBiology. Discover how AlphaFold 1 → 2 → 3 revolutionized protein structure prediction & accelerates #DrugDiscovery. 🔗 Read more: creative-biostructure.com/evolution-of-a… #AlphaFold
CCR9 is chemokine receptor involved in gut inflammation and cancer. Here, the authors use AI-based modeling, protein engineering and pharmacological experiments to reveal the unusual anatomy of CCR9 activation by its endogenous chemokine agonist CCL25. nature.com/articles/s4146…
From snapshots to “molecular movies” 🎥 — Time-resolved #CryoEM captures fleeting molecular states with millisecond precision. See how it’s transforming drug discovery, GPCR research, and viral dynamics. 🔗 Read more: creative-biostructure.com/resource-time-… #MolecularDynamics #DrugDiscovery
The authors resolve high-resolution structures of complex multimeric RNA-only assemblies, redefining our understanding of non-coding RNA architecture and expanding the landscape of naturally evolved RNA nanostructures. nature.com/articles/s4159…
Cryo-EM captures proteins and viruses in atomic detail—no crystallization required. Explore its principles, tools, and transformative impact on structural biology and drug discovery. 👉creative-biostructure.com/cryo-em-techno… #CryoEM #DrugDiscovery #ElectronMicroscopy #CreativeBiostructure
The authors use several structural approaches to analyze the distribution of nucleosomes at the lamin–chromatin interface, test the impact of lamins on nucleosome density and identify a lamin A nucleosome-binding motif. nature.com/articles/s4159…
Cryo-EM reveals high-resolution protein structures—no crystallization needed. From membrane proteins to GPCRs and dynamic complexes, see how Cryo-EM supports modern drug discovery. 👉 creative-biostructure.com/resource-cryo-… #CryoEM #ProteinStructure #DrugDiscovery #CreativeBiostructure
The authors determined the cryo-EM structure of human GTPase-activating protein complex GATOR2 bound to CASTOR1 in the absence of arginine, providing insight into how CASTOR1 binds to GATOR2 to disinhibit GATOR1 when arginine levels are low. nature.com/articles/s4159…
CD spectroscopy reveals structure, stability, and comparability in biologics, mAbs, and mRNA vaccines. Discover how it supports QC and regulatory success in biopharma R&D. 👉 creative-biostructure.com/resource-cd-sp… #CDSpectroscopy #Biopharma #ProteinStructure #CreativeBiostructure
CD163 is a macrophage receptor that clears toxic hemoglobin-haptoglobin complexes. Here, the authors reveal the structure of CD163 bound to its ligand and show that calcium-dependent oligomerization promotes efficient endocytosis. nature.com/articles/s4146…
New to Circular Dichroism? Learn how CD spectroscopy reveals protein structure, folding, and ligand binding with speed and precision. Start with our expert beginner’s guide 👉 creative-biostructure.com/resource-circu… #CDSpectroscopy #ProteinStructure #CreativeBiostructure
Adrenergic and muscarinic receptors are key GPCRs involved in vital functions. Here, the authors engineer toxin variants that selectively target α2A and M4AChR, offering new tools and therapeutic leads through a structure-guided design strategy. nature.com/articles/s4146…
🧬 Protein X-ray Crystallography isn’t just old-school—it’s still the MVP of drug discovery. 🎯 Target validation 🔍 Binding site analysis 🧩 Fragment screening ⚙️ AI + Cryo-EM integration Explore how this technique is evolving: creative-biostructure.com/resource-x-ray… #DrugDiscovery
Structural, biochemical, and cellular data show that trafficking kinesin-binding protein 1 (TRAK1) binds Mitochondrial Rho GTPase 1 (MIRO1) through two distinct Ca²⁺- and GTP-independent sites, both contributing to mitochondrial localization. nature.com/articles/s4146…
AlphaFold 3 reshapes drug discovery with accurate modeling of targets, ligands, and resistance mutations. Creative Biostructure bridges prediction with validation to drive faster and smarter drug design. 👉 creative-biostructure.com/integrating-al… #AlphaFold3 #DrugDiscovery #ProteinStructure
New Article: Interactions between TTYH2 and APOE facilitate endosomal lipid transfer The Tweety homologue TTYH2 is identified as the lipid transfer mediator for APOE-containing lipoproteins. nature.com/articles/s4158…
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