Evidentis™ Clinical Research @EvidentisHQ
Advancing liver & metabolic health through our own Phase 1–4 clinical trials, while partnering with others through collaboration & strategic partnerships. Joined July 2025-
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Ionis Phase III show impressive results: Olezarsen (Tryngolza) in severe hypertriglyceridemia lowered triglycerides by ~72% vs placebo and reduced acute pancreatitis events by 85%. Impact is meaningful but niche — the true potential lies in broader cardiometabolic expansion.
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Evidentis™ Clinical Research retweeted
CIRROXABAN trial: In cirrhosis w/ portal HTN, rivaroxaban 10mg daily improved complication-free survival vs placebo (47%→27%). Benefit strongest in Child-Pugh B7. ↑ mild bleeds, but no ↑ in major bleeds. Promising role for anticoagulation in cirrhosis. journal-of-hepatology.eu/article/S0168-…
Evidentis™ Clinical Research retweeted
Study in >30k veterans with MASLD in @HEP_Journal Each 5 kPa rise in liver stiffness ↑ HCC risk by 18%. Non-cirrhotic MASLD pts with diabetes + LSM ≥10 kPa cross the threshold for cost-effective HCC surveillance. Routine screening may be warranted. journals.lww.com/hep/abstract/9…
Exciting trial news: @ZydusUniverse reports positive Phase 2b/3 results for Saroglitazar in primary biliary cholangitis. 48.5% achieved response vs placebo (p<0.001). US filing planned 2026. Expanding options for our patients. #LiverDisease @parulsood prnewswire.com/news-releases/…
FDA accepts proposal for a “reasonably likely” surrogate endpoint in #MASH trials: Liver stiffness by vibration-controlled transient elastography (VCTE) A step toward replacing invasive biopsies with non-invasive tools in drug development @Echosens fda.gov/drugs/drug-saf…
Promising news in obesity + diabetes research: @EliLillyandCo oral GLP-1 orforglipron once daily dosing hits its third Phase 3 trial target (ATTAIN-2). Patients lost ~10.5% body weight (~23 lbs) with glycemic improvements. Awaiting peer-reviewed data. investor.lilly.com/news-releases/…
Betaine 2–8 g/day (12–24 wks) reduced ALT, AST, CK18, Pro-C3 & MASEF in MASLD pts with ↑ALT @HEP_Journal @AASLDtweets ~35% had only mild, transient GI symptoms. Promising signal—future data eagerly awaited. journals.lww.com/hep/abstract/9…
Phase 2 data @Viking_VKTX oral GLP-1/GIP agonist VK2735 = 12.2% mean weight loss at 13 wks vs 1.3% with placebo. ≥10% WL in 80% on drug vs 5% placebo. GI AEs mostly mild/mod; discontinuation rates higher—clarity coming in Phase 3. Promising. ir.vikingtherapeutics.com/2025-08-19-Vik…
Phase 2 trial of once-monthly MariTide (maridebart cafraglutide) @NEJM : 12–16% mean weight loss at 52 wks in obesity without diabetes, 8–12% with diabetes. Placebo ~2%. Sustained cardiometabolic benefits. Potential game-changer for adherence. nejm.org/doi/10.1056/NE…
Resmetirom (Rezdiffra): Approved in 2024; Data now shows it improves MASH-related noninvasive measures and portal pressure. ir.madrigalpharma.com/news-releases/…
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