Fitzpatrick Laboratory @FitzpatrickLab
Assistant Professor @ZuckermanBrain @ColumbiaBiochem. Lab uses cryo-EM & biophysics to study the cellular, molecular, and structural basis of neurodegeneration. fitzpatrick-lab.org New York, NY Joined January 2013-
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Fitzpatrick Laboratory retweeted
CSF total tau as a proxy of synaptic degeneration: nature.com/articles/s4146…
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Fitzpatrick Laboratory retweeted
Apoptotic vesicle release from a cell as it gives up the ghost under oxidative stress, as seen by MOSAIC lattice light sheet mode.
Fitzpatrick Laboratory retweeted
Exciting to see our protein binder design pipeline BindCraft published in its final form in @Nature ! This has been an amazing collaborative effort with Lennart, @csche11h, @sokrypton, @befcorreia and many other amazing lab members and collaborators. nature.com/articles/s4158…
Fitzpatrick Laboratory retweeted
We’re excited to announce our new paper on Time-deterministic cryo-optical microscopy! This technique rapidly freezes living cells during imaging, adding temporal info to cryo-fixed samples for deeper analysis. Huge thanks to our amazing collaborators. nature.com/articles/s4137…
Fitzpatrick Laboratory retweeted
SLC45A4 is a pain gene encoding a neuronal polyamine transporter | Nature nature.com/articles/s4158…
New "Mindscapes" exhibit @ZuckermanBrain featuring #cryoEM structures of #TMEM106B #amyloid fibrils (doi.org/10.1016/j.cell…) & the ligand-bound human sweet receptor (doi.org/10.1016/j.cell…) from the Fitzpatrick (fitzpatrick-lab.org) & Zuker (zukerlab.com) labs.
Fitzpatrick Laboratory retweeted
CryoEM structure of the human uromodulin filaments (PDB code: 9NU3) #scivis #molecularart @dzine_ai @proteinimaging behance.net/gallery/226765…
Fitzpatrick Laboratory retweeted
New online! Integrated structural biology of the native malarial translation machinery and its inhibition by an antimalarial drug bit.ly/4mluP07
Fitzpatrick Laboratory retweeted
Our #CryoET story on how a top antimalarial drug candidate perturbs the native malarial translation machinery is out @NatureSMB🥳rdcu.be/eBbrH Massive team effort led by @leonie_anton @mehsehret @Wenjing_Cheng_ in collaboration with @DziekanJerzy @CowmanAlan #teamtomo
Fitzpatrick Laboratory retweeted
The new issue is out👉cell.com/cell/current On the cover, Haziza et al. image high-frequency voltage dynamics in multiple neuron classes of behaving mammals, highlighting the brain's hidden electrical code underlying perception, thoughts, and emotions.
Fitzpatrick Laboratory retweeted
Hi everybody! I am super excited to share the work done during my PhD published in @Nature today! We describe a new mechanism of self- vs. non-self RNA discrimination by showing how N-glycans shield glycoRNAs from stimulating endosomal RNA sensors nature.com/articles/s4158…
Fitzpatrick Laboratory retweeted
The molecular basis of lamin-specific chromatin interactions nature.com/articles/s4159…
Fitzpatrick Laboratory retweeted
Potato evolved from tomato 9 million years ago. cell.com/cell/fulltext/… @NHM_London Sandra Knapp @UBC Loren H. Rieseberg @SCUCN Jianquan Liu #CAAS Sanwen Huang @CellCellPress
How we taste sweetness: long-sought structure of human receptor mapped at last nature.com/articles/d4158…
Fitzpatrick Laboratory retweeted
In the latest issue! The structure of human sweetness dlvr.it/TM6Tpg
Fitzpatrick Laboratory retweeted
Online now! Automated identification of small molecules in cryoelectron microscopy data with density- and energy-guided evaluation dlvr.it/TM6fxv
Fitzpatrick Laboratory retweeted
Structural insights into brain thyroid hormone transport via MCT8 and OATP1C1: Cell cell.com/cell/abstract/…
Fitzpatrick Laboratory retweeted
Synaptic loss pattern is constrained by brain connectome and modulated by phosphorylated tau in Alzheimer’s disease nature.com/articles/s4146…
Forward-looking preview by @WUBin10069342 to our latest paper @Structure_CP by @AndrewNChang highlighting the power of #AI in #cryoEM of patient-derived samples: tinyurl.com/tu2fyvme Paper: tinyurl.com/3cycffzm Thanks to @pixelbaumarkt @Intein for #crYOLO, & @cryosparc
Fitzpatrick Laboratory retweeted
Neuroinflammation across neurological diseases @ScienceMagazine science.org/doi/10.1126/sc…
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