Stopping for Futility @FutilityRule

Poor design and execution of clinical trials. Now featuring hand-crafted, locally-sourced, organic placebo The parallel group Joined November 2021

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Maarten van Smeden @MaartenvSmeden

2 years ago

This is why people pleading for academic storytelling always make me slightly uncomfortable

Edward Tufte @EdwardTufte

2 years ago

This is why people pleading for academic storytelling always make me slightly uncomfortable

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Matthew Herper @matthewherper

2 years ago

Credit where it’s due: ⁦@DerekLowe⁩ was dead right about $EQRX. science.org/content/blog-p…

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Shockingly some med students & docs are amplifying RFK Jr as he runs for president, so let's review his embarrassing track record. -claimed autism was a form of mercury poisoning. Wrong. -claimed thimerosal in vaccines caused autism. Wrong. sciencebasedmedicine.org/mercury-in-vac… 1/n

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Matthew Herper @matthewherper

3 years ago

Northwest Bio study of brain cancer vaccine still falls short statnews.com/2022/11/21/nor…

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Stopping for Futility @FutilityRule

3 years ago

SO BRAVE

John Mandrola, MD @drjohnm

3 years ago

SO BRAVE

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Aaron Mitchell @TheWonkologist

3 years ago

Did you know that the immunotherapy monoclonals (pembro, nivo) maintain their effectiveness at a fraction of the FDA-approved dose? Huge potential for cost-savings here. See my and @drdgoldstein's commentary in @JCO_ASCO today 👇🏼👇🏼👇🏼 ascopubs.org/doi/abs/10.120… 1/

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Stopping for Futility @FutilityRule

3 years ago

More evidence that randomization and blinding have a powerful inhibitory effect on ivermectin, and they should be avoided at all costs.

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Brian Nosek (@[email protected]) @BrianNosek

3 years ago

Hypothesis: Increasing rigor makes researchers more appealing to industry. Consequence: Academic fields that improve rigor will then need to up their game on pay and other parts of culture to compete with industry and retain the benefits of having improved.

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Stopping for Futility @FutilityRule

3 years ago

Clinical research: the one field that you don't have to be embarrassed that your strategy is "still hoping"

MACRO_ENT_Trial @MACRO_ENT_Trial

3 years ago

Clinical research: the one field that you don't have to be embarrassed that your strategy is "still hoping"

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Stopping for Futility @FutilityRule

3 years ago

a trial where everyone gets one of 2 options can be a perfectly good trial, but how on earth is is a "precision medicine" trial?

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Stopping for Futility @FutilityRule

3 years ago

Close finish - neck and neck until the very end!

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Stopping for Futility @FutilityRule

3 years ago

The four phases of pharma clinical trials, explained: I. Try really hard not to kill anyone II. Mostly designed to appease the whims of our senior medical director III. Actually run a rigorous study IV. We'll get to that eventually