John Mandrola, MD @drjohnm
Heart rhythm doc, writer for @Medscape, host of This Week in Cardiology podcast, editor of Sensible Medicine. The more you see, the harder medicine gets. johnmandrola.substack.com Louisville, KY Joined May 2010-
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I am writing the script for This Week in Cardiology podcast in a sunlit restaurant in Rzeszow Poland and on the sound system is American country music Just an observation. It's nice, actually.
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John Mandrola, MD retweeted
During residency, I was surprised to discover the profound influence that screening incentives have on primary care. I am not convinced they improve patient outcomes. This is my latest in Sensible Medicine. open.substack.com/pub/sensibleme…
John Mandrola, MD retweeted
@drjohnm Practice-changing findings! Trial was powered to detect HR of 0.75 in favor of dual pathway inhibition. What the trial found was a HR of 1.53 with dual pathway inhibition. Premature truncation might have ‘softened’ the risk of death and bleeding outcomes. Time for recalibration!
The AQUATIC trial may be the most definitive trial of #ESCCOngress The common combo of ASA and OAC for pts with CAD/stent and AF is clearly been harming people. Lots. MACE worse, Death worse, Bleeding way worse. STOP THE ASA when on OAC nejm.org/doi/full/10.10…
John Mandrola, MD retweeted
Time to Nix the Primary Prevention ICD? medscape.com/viewarticle/ti… via @drjohnm
Dear #ESCCongress -- thx for such a great meeting. We all have a lot of work to do digging into all these trials. There are so many. Here are my first three: DIGIT HF medscape.com/viewarticle/fi… REBOOT/BETAMI-DANBLOCK medscape.com/viewarticle/be… REFINE ICD medscape.com/viewarticle/ti…
John Mandrola, MD retweeted
The first RCT to show that use of a clinical risk score to guide care can improve hard cardiovascular outcomes. In PARTHENOPE, using the DAPT score to guide antiplatelet duration after PCI reduced net adverse events vs standard 12 month DAPT. Congrats @piccoloraf and team!
The first RCT to show that use of a clinical risk score to guide care can improve hard cardiovascular outcomes. In PARTHENOPE, using the DAPT score to guide antiplatelet duration after PCI reduced net adverse events vs standard 12 month DAPT. Congrats @piccoloraf and team!
Cooking w gas today at #esccongress Writing outside akin to riding w a tailwind. Beta blocker thoughts coming any moment. Just sent in my post on the null results of REFINE ICD. Gosh does the primary prevention ICD need a fresh look. Stay tuned.
John Mandrola, MD retweeted
DIGIT-HF trial has started a snowball effect in heart failure research! Are we in front of the fifth pillar in HFrEF? 🤔 .. Watch my interview with John Mandrola @drjohnm from Louisville, Kentucky, USA and see his 5 learnt lessons from this trial. #ESCCongress @escardio
John Mandrola, MD retweeted
DANCAVAS 2: In >31,000 men aged 60–64, population-based CV screening did not significantly reduce mortality, but increased preventive therapy use – and severe bleeding risk. #ESC25 #Cardiology
I sent in my post-MI beta-blocker column. Teaser: the clinical translation is easy. Stay tuned. #ESCCongress #esc2025
I’ll have it finished by 0800 tomorrow. Out later in the day. It will be a short piece I think. Pretty clear answer. Right @AndrewFoy82
I’ll have it finished by 0800 tomorrow. Out later in the day. It will be a short piece I think. Pretty clear answer. Right @AndrewFoy82
John Mandrola, MD retweeted
Full immersion at #ESCCongress2025 & World Congress of #Cardiology in Madrid 🇪🇸. #Epeeps @drjohnm 50(!) sessions on ATTR-CA, plus AI, LBBAP & many new guidelines. Take-home so far: β-blockers (BETAMI-DANBLOCK), digitoxin (DIGIT-HF) & CRT (PhysioSync-HF) — oldies but goodies.
I’m happy to crowdsource the beta blocker after MI data. Conflicting trials today. Attempts to find heterogeneous effects. Why would an LVEF of 44% be less likely to have MI w BB than a person w LVEF 51%. In skeptical. What say you? #ESC2025
John Mandrola, MD retweeted
John Mandrola, MD retweeted
J'aime ce passage de l'éditorial de @drjohnm sur l'étude DIGIT-HF. Les digitaliques ou le serpent de mer de la cardiologie. Que ça aboutisse ou non à des recos, c'est rassurant de voir des études de cette ampleur sur des médicaments qui ne coûtent rien. medscape.com/viewarticle/fi…
Darn it. There’s no editorial. Why? Because the heart failure community is stunned. They are speechless. No worries. You can read this (slightly biased) editorial for free on @theheartorg medscape.com/viewarticle/fi… #esccongress #esc2025
Darn it. There’s no editorial. Why? Because the heart failure community is stunned. They are speechless. No worries. You can read this (slightly biased) editorial for free on @theheartorg medscape.com/viewarticle/fi… #esccongress #esc2025
Hear hear cc @escardio
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