🧠 Alzheimer’s disease (AD) care is entering a new era.
Promising new antibody treatments offer hope, but more research is needed to optimise their use.
A new Lancet Series highlights crucial next steps in diagnosis, treatment, & prevention globally: hubs.ly/Q03K5-S40
In the PROMIZING trial, proportional-assist ventilation with load-adjustable gain factors did not differ significantly from pressure-support ventilation with respect to the time to liberation from mechanical ventilation. Full trial results and Research Summary:…
One tip that is a game-changer when studying for the USMLE:
Early morning studying (~5 AM).
Prioritize sleep for optimal retention, and switch your chronotype to early AMs.
While the world is sleeping, you'll be in a mode of 'deep work.'
'What % correct should I get on my UWorld blocks to pass or score well on the USMLE?'
Not an easy answer. Not validated by any study.
My 2 rupees:
• Focus on learning & scoring a bit better than your last block.
It's all about honing in on what you can control.
I often say peace is the best medicine. That's not just a slogan, it's based on evidence. In countries affected by conflict and insecurity:
-70% of disease outbreaks erupt
-Half of all child deaths globally occur
-1 in 5 people suffer from mental health disorders.
Peace…
A 30-year-old woman presented with a 10-week history of painful skin nodules and a 6-week history of fevers and night sweats. A physical examination was notable for palpable subcutaneous nodules with overlying erythema.
Read the full case details in the Images in Clinical…
Among preterm infants 22-28 weeks gestation, providing 100% oxygen during deferred cord clamping reduces early #hypoxemia without increasing morbidity and mortality. ja.ma/41wSzpE
When reviewing a UWorld block, pay attention to areas where you miss ≳3 questions in a row.
Usually this is due to an issue with strategy or psychology.
Analyze what 'went wrong' as it's the low-hanging fruit of improving on the next block.
Tumor lysis syndrome has evolved and become less predictable with the introduction of new cancer therapies. A new review explores risk factors and causes of the syndrome, as well as strategies for treatment and prevention.
Learn more in the Review Article “Tumor Lysis Syndrome”…
Case report: the appearance of autosomal recessive limb-girdle muscular dystrophy in a 30-year-old man with lower limb weakness, asymmetric atrophy of thigh muscles, and wasting of calf muscles. ja.ma/464uHfR@atabisneuro
Being vaccinated against hepatitis B may reduce chronic inflammation levels in the body, which could help ward off diabetes newscientist.com/article/249469…
In patients with refractory systemic lupus erythematosus, in vivo generation of CD19 CAR T cells by means of lipid nanoparticles led to B-cell depletion, reduced disease activity, and no major toxic effects. Full study results: nej.md/42u4eWF
Zhu et al. reveal elevated glucose uptake in the hippocampi of aged humans and macaques, and show that an interaction between STT3A and ALG5 facilitates GLUT4 transport to offset reduced GLUT3-mediated glucose metabolism. tinyurl.com/3fvup9wj
In a 93-year-old woman with a history of aortic stenosis who was evaluated for dyspnea, transthoracic echocardiography (shown in videos) was used to assess for progression of aortic stenosis.
Read the full case details in "A 93-Year-Old Woman with Dyspnea and Fatigue,” a Case…
In a USMLE study session, have a:
• Singular resource focus (i.e. UWorld, NBME, etc.)
• Reflective mindset - 'why' did you miss the question
•Global lens of the vignette > buzzwords
It's about studying intentionally with intensity.
A 37-year-old woman presented with a 4-day history of pain, swelling, and bruising on the upper portion of her left knee after using a massage gun. She reported no other bruising or bleeding apart from chronic menorrhagia.
Closer examination of the patient’s legs showed…
A 75-year-old man presented with a 3-week history of fatigue and palpitations. Bulging of the biceps during elbow flexion was noted. ECG showed low-voltage QRS complexes, and echocardiography showed left ventricular hypertrophy.
Read the full case details in the Images in…
Trigeminal trophic syndrome (TTS) is an underrecognized poststroke complication in patients with facial hypoesthesia. Despite therapeutic challenges, it is a treatable condition often requiring a multimodal approach. Learn more in this #NeurologyRF case: hubs.la/Q03FhRjs0
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