Fahreddin Palaz, MD @CRISPRvs
Postdoctoral Research Fellow @UFMedicine | #GenomeEngineering 🧬, #CancerResearch 🔬, #GeneTherapy and #Immunotherapy💊 Gainesville, FL Joined May 2020-
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Fahreddin Palaz, MD retweeted
In @NatureGenet we report that base editing of trinucleotide repeats (TNRs) reduces somatic repeat expansions in Huntington’s disease (HD) and Friedreich’s ataxia (FRDA)—in patient-derived cells and in vivo—a collaboration with the Mouro Pinto lab. drive.google.com/file/d/1on7kdy… 1/14
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Fahreddin Palaz, MD retweeted
In a first-in-human trial, 12 metastatic colorectal cancer patients (with prior progression on treatment) received CISH-knockout CRISPR T cells. Six had stable disease, one had a lasting complete remission, and no severe CRS or neurotoxicity occurred. @TheLancetOncol *
Fahreddin Palaz, MD retweeted
We are excited to report the discovery of TIGRs, a widely-occurring RNA-guided system found in bacteria and their viruses. TIGRs consist of a peculiar repeat region which is transcribed into RNA and processed into multiple guide RNAs to direct TIGR-associated proteins to their…
Fahreddin Palaz, MD retweeted
Original Article: Xenotransplantation of Porcine Kidney for End-Stage Kidney Disease nej.md/3Esayoz #ISNWCN | @ISNWCN
Fahreddin Palaz, MD retweeted
Excited to share our new publication in @LTxJournal *: “Immune Checkpoint Inhibitors in the Post-Transplant Landscape of Hepatocellular Carcinoma: A Systematic Literature Review.” A special congratulations to our first author, @dogakahramangil a talented resident and promising…
Fahreddin Palaz, MD retweeted
Next-generation CRISPR-based gene-editing therapies tested in clinical trials. Read the latest in the Clinical Pipeline, by Natalie Healey. nature.com/articles/d4159…
Fahreddin Palaz, MD retweeted
Epigenome editing technologies for discovery and medicine go.nature.com/4cXw54M
Fahreddin Palaz, MD retweeted
Engineering focusing on cancer! 🔴Cancer engineering is an emerging subfield of biomedical engineering that unifies engineering and cancer biology to better understand, diagnose, and treat cancer. @CellPressNews @OncoAlert doi.org/10.1016/j.ccel…
Fahreddin Palaz, MD retweeted
Excited to share our new review article on #CRISPR technology in advanced #HCC treatment ! 🧬 Special thanks to our first author @CRISPRvs for leading this effort. @The__Liver @DovePress @UFHealthCancer dovepress.com/crispr-in-targ…
New study in @NatureBiotech reveals that Cas9 enzymes, similar to Cas12 and Cas13, exhibit collateral (trans) cleavage activity in vitro, specifically targeting ssDNA and ssRNA substrates. #CRISPR #Cas9 #GenomeEditing go.nature.com/3UZYUpx
Fahreddin Palaz, MD retweeted
Excited to share our latest work, motivated by the challenge of efficient prime editing in HSCs. We find that the metabolic state of quiescent cells presents a hurdle—but it’s surmountable, by boosting dNTPs. Led by the incomparable @SbastienLevesq4. rdcu.be/dJdgK
Excited to share our latest work, motivated by the challenge of efficient prime editing in HSCs. We find that the metabolic state of quiescent cells presents a hurdle—but it’s surmountable, by boosting dNTPs. Led by the incomparable @SbastienLevesq4. rdcu.be/dJdgK
Fahreddin Palaz, MD retweeted
Google DeepMind has written a SECOND paper about Med-Gemini, introducing 3 new models to the family! 🔥 Med-Gemini achieves state-of-the-art on various medical imaging tasks! 🩻🔬🧬 IMO multimodal AI is the future of medicine so excited to see this paper, let's dive in! ↓↓↓
Fahreddin Palaz, MD retweeted
New England Journal of Medicine paper released today - what started as the first in vivo clinical trial for CRISPR gene editing, for CEP290-associated retinal degeneration. Congrats to all. @MassEyeAndEar @harvardmed @HMSeye @CaseyEye @editasmed #ARVO2024 nejm.org/doi/full/10.10…
Fahreddin Palaz, MD retweeted
Perspective: Welcoming the Era of Gene Editing in Medicine nej.md/4d9XbGt #Hematology
Fahreddin Palaz, MD retweeted
Of 30 patients with severe #SickleCellDisease who were treated with gene-edited autologous hematopoietic stem and progenitor cells, 29 were free from vaso-occlusive crises for at least 12 consecutive months. Read the full CLIMB SCD-121 study results: nej.md/3UvzPDT
Fahreddin Palaz, MD retweeted
What does a 'cure' mean in multiple myeloma? Is it even possible? In this review, we first try to define a cure and then provide the evidence for why some patients may actually reach this milestone. First: our definition (see below). authors.elsevier.com/a/1f0qL,yeo3ud…
Fahreddin Palaz, MD retweeted
Awesome work by Britt, Jun and team. This could help in translating prime editing to the clinic by boosting its efficiency with standard length pegRNAs.
Awesome work by Britt, Jun and team. This could help in translating prime editing to the clinic by boosting its efficiency with standard length pegRNAs.
Fahreddin Palaz, MD retweeted
CRISPR-Cas9 In Vivo Gene Editing of KLKB1 for Hereditary Angioedema | NEJM nejm.org/doi/full/10.10…
Fahreddin Palaz, MD retweeted
Just shared at @KeystoneSymp a new @arcinstitute discovery of the bridge RNA recombinase mechanism: a new class of natural RNA-guided systems that retains the key property of programmability from RNAi and CRISPR while enabling large-scale genome design beyond RNA and DNA cuts
Fahreddin Palaz, MD retweeted
Today we report in @NatureBiotech an engineered virus-like particle system for in vivo delivery of prime editor protein-RNA complexes. This PE-eVLP platform can support therapeutic prime editing in animal models of genetic disease. /1 drive.google.com/file/d/1xd7Yzz…
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