Ben Derman @bdermanmd
Asst Professor at University of Chicago, specializing in (vanquishing) plasma cell disorders. I tweet about: Myeloma & MRD. https://t.co/mPeWg1QRrW Chicago, IL Joined June 2017-
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This is an excellent piece summarizing what is known about CAR T cell therapy and T cell lymphomas. And with an appearance from @Rfonsi1! nature.com/articles/d4158…
Just out: International Myeloma Working Group guidelines for bispecific antibodies myeloma. Limited time: Free copy link in the thread. @TheLancetOncol @paurotero @JKaufmanMD @szusmani @YiLinMDPhD @TomBmt133 @mvmateos @bdermanmd @MinnemaMonique et al thelancet.com/journals/lanon…
5-year follow-up from the LEGEND-2 study of cilta-cel ⏳ 5-year PFS 21% and OS 49% (despite variable LD). 3 progressions after 5 years. No plateau! 🧠No delayed neurotox 🩸No 2nd heme malignancies 🏋️T cells persisted >1 year for VGPR+ (1 at 5.6 years!) jhoonline.biomedcentral.com/articles/10.11…
What does a 'cure' mean in multiple myeloma? Is it even possible? In this review, we first try to define a cure and then provide the evidence for why some patients may actually reach this milestone. First: our definition (see below). authors.elsevier.com/a/1f0qL,yeo3ud…
Briefing documents from the FDA suggest that they accept the arguments laid forth by the i2TEAMM initiative and would accept MRD neg as an intermediate clinical endpoint to support AA fda.gov/media/177652/d…
Tune in to FDA discussion on MRD as a surrogate end point in Myeloma youtube.com/watch?v=pooME9…
Things are about to get interesting- that’s for sure! Great news that Carvykti approved for second line and beyond! Who should get in second line is a big question - Will be a nuanced discussion! businesswire.com/news/home/2024…
Excited to speak at the @UCCancerCenter Development Therapeutics Conference in a few weeks with a terrific lineup of speakers! @bdermanmd @rajatthawani @JosephFranses @DanielOlsonMD @myeloidmalig …lopmentaltherapeutics.squarespace.com/agenda
ODAC vote: 8 yes and 3 no in favor of ide-cel to move up in lines of therapy. Surprising based on the level of data that was presented in my opinion. I think if PFS1 + PFS2 for both arms were shown, we would see it parallels OS signal.
Vincent Rajkumar @VincentRK
81K Followers 2K Following Editor-in-Chief, Blood Cancer Journal; Oncologist; Cancer Research; Opinions are solely my personal views https://t.co/HOGYJSpsoGRahul Banerjee, MD, F.. @RahulBanerjeeMD
9K Followers 4K Following Asst Professor @UWMedicine @fredhutch. Goals: improve pt experience in myeloma #MMsm: ⬇️ dex, ⬆️ time at home, 📱-based wellness. COI: https://t.co/3Uuojuio6RManni Mohyuddin @ManniMD1
12K Followers 491 Following Cancer doctor with interest in myeloma, supportive care, end of life, cost-effective/evidence-based care and med-ed. Views own.Nico Gagelmann @NicoGagelmann
38K Followers 750 Following @TheEBMT_Trainee co-chair. Hematology. Medicine. Science. Train. Think. Implement an integral actuality.Mohamad Mohty @Mohty_EBMT
20K Followers 3K Following Professor and head of Hematology Sorbonne Univ.; past-president of the EBMT; Chairman of the IACH; Editor in Chief: Bone Marrow Transplant; Clin Hematol Int.Saad Z. Usmani MD MBA.. @szusmani
11K Followers 618 Following Chief of Myeloma @MSKCancerCenter | Chair @ALLIANCE_org #mmsm Com | MD ≠ Provider| @ASH_hematology @ASTCT @ASCO |married to @ZainabShd | #BMTsm #CARTsm #CureMMRafael Fonseca MD �.. @Rfonsi1
15K Followers 3K Following Chief Innovation Officer - Mayo Clinic in Arizona. Myeloma doctor. Visiting Healthcare Fellow @GoldwaterInst. Tweets-own/RT not an endorsementSamer Al Hadidi, MD,M.. @HadidiSamer
4K Followers 311 Following Assistant professor @UAMSMyeloma. Alumni heme/onc @bcmhouston, clinical research/biostat @UMich.Focus on plasma cell disorders & health disparitiesRaj Chakraborty @rajshekharucms
4K Followers 340 Following Hematologist/Oncologist/Clinical Researcher @ColumbiaCancer #Myeloma #Amyloidosis Asst. Prof @ColumbiaMed Host @BloodCancerTalk COI: https://t.co/du0rVMRFkC@MyelomaTeacher - Cin.. @MyelomaTeacher
10K Followers 2K Following Retired Teacher- Dx with Myeloma 2008- Patient Research Advocate-Curriculum Director @HealthTreeU- @ASH_Hematology & @TheEBMT Speaker-IRB Member, #MMSMAjay Major, MD, MBA @majorajay
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6K Followers 481 Following Mary and Bill Battle Professor of Multiple Myeloma. Immunotherapy , cellular therapy, clinical trials. I unapologetically believe MM can be CURED.Urvi Shah @UrviShahMD
3K Followers 1K Following Oncologist and researcher on Myeloma service @mskcancercenter Interested in nutrition 🌱 for cancer and immune therapies. Cancer survivor. Views are my ownKate Retz @KARetz14
0 Followers 27 FollowingKelly Meza, MD @KellyMezaMD
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71 Followers 145 FollowingYoonhee C @Yoonhcblood
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2 Followers 35 FollowingGessie Anne Lopes MD @GessieAnneLopes
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152 Followers 582 Following IM PGY-2 @laheyhospital; Postdoc research fellow @Harvardmed @BIDMChealth. Interested in hematology/oncology 🩸Berrin Balik @BalikBerrin
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177 Followers 204 Following Associate Professor, Dept. of Hematooncology, University Hospital Ostrava; Head of flow cytometry core, Blood Cancer Research Group, University of OstravaMike Canfield @jupitersurfski
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434 Followers 4K Following Full time technology enthusiast, love Databases and everything that goes with it. Passionate about DB performance and Equities. Ex Cadila, SEBI, DellMaansi Joshi @JoshiMaansi
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124 Followers 142 Following Current Heme/Onc fellow @SinaiHemeOnc via @BIDMC_IM and @YaleMed | He/HimBoba Street Gang Capi.. @bsg_cap
375 Followers 670 FollowingAmy C. Cavers @cavemom11
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117 Followers 241 FollowingVincent Rajkumar @VincentRK
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9K Followers 4K Following Asst Professor @UWMedicine @fredhutch. Goals: improve pt experience in myeloma #MMsm: ⬇️ dex, ⬆️ time at home, 📱-based wellness. COI: https://t.co/3Uuojuio6RManni Mohyuddin @ManniMD1
12K Followers 491 Following Cancer doctor with interest in myeloma, supportive care, end of life, cost-effective/evidence-based care and med-ed. Views own.Nico Gagelmann @NicoGagelmann
38K Followers 750 Following @TheEBMT_Trainee co-chair. Hematology. Medicine. Science. Train. Think. Implement an integral actuality.Mohamad Mohty @Mohty_EBMT
20K Followers 3K Following Professor and head of Hematology Sorbonne Univ.; past-president of the EBMT; Chairman of the IACH; Editor in Chief: Bone Marrow Transplant; Clin Hematol Int.Saad Z. Usmani MD MBA.. @szusmani
11K Followers 618 Following Chief of Myeloma @MSKCancerCenter | Chair @ALLIANCE_org #mmsm Com | MD ≠ Provider| @ASH_hematology @ASTCT @ASCO |married to @ZainabShd | #BMTsm #CARTsm #CureMMRafael Fonseca MD �.. @Rfonsi1
15K Followers 3K Following Chief Innovation Officer - Mayo Clinic in Arizona. Myeloma doctor. Visiting Healthcare Fellow @GoldwaterInst. Tweets-own/RT not an endorsementC. Ola Landgren, M.D. @DrOlaLandgren
11K Followers 91 Following Professor of Medicine, Chief of Myeloma Division & Translational Clinical Oncology Program. Sylvester Comprehensive Cancer Center, Univ of Miami. Tweets = mineDavid Steensma, MD @DavidSteensma
25K Followers 463 Following Hematologist-oncologist. @AjaxThx CMO. Former Edward P. Evans Chair in MDS @DanaFarber, @HarvardMed & @MayoClinic faculty, @NovartisScience hematology head.Samer Al Hadidi, MD,M.. @HadidiSamer
4K Followers 311 Following Assistant professor @UAMSMyeloma. Alumni heme/onc @bcmhouston, clinical research/biostat @UMich.Focus on plasma cell disorders & health disparitiesRaj Chakraborty @rajshekharucms
4K Followers 340 Following Hematologist/Oncologist/Clinical Researcher @ColumbiaCancer #Myeloma #Amyloidosis Asst. Prof @ColumbiaMed Host @BloodCancerTalk COI: https://t.co/du0rVMRFkC@MyelomaTeacher - Cin.. @MyelomaTeacher
10K Followers 2K Following Retired Teacher- Dx with Myeloma 2008- Patient Research Advocate-Curriculum Director @HealthTreeU- @ASH_Hematology & @TheEBMT Speaker-IRB Member, #MMSMAjay Major, MD, MBA @majorajay
7K Followers 2K Following Lymphoma faculty @CUHematology. Patient-reported outcomes & quality of life researcher in #lymsm. Founder of https://t.co/kN6qeGGce5 & @inTrainingDoc. 🌈Joseph Mikhael @jmikhaelmd
7K Followers 474 Following Hematologist, Myeloma Expert, Communication Enthusiast. Professor at TGen/City of Hope and Chief Medical Officer of the International Myeloma FoundationJoshua Richter, MD, F.. @JoshuaRichterMD
3K Followers 483 Following Associate Professor of Medicine, Hematology, and Medical Oncology Center of Excellence for Multiple Myeloma @TischCancer @IcahnMountSinai @MountSinaiNYCchadi nabhan MD, MBA,.. @chadinabhan
19K Followers 787 Following Heme/Onc; NHL/HL/CLL. Adj Professor U of SC; Host: the #HealthcareUnfiltered & the #HemOnc Pulse podcasts. Author of "TOXIC EXPOSURE" & “THE CANCER JOURNEY.”Daniel Auclair @AuclairDan
4K Followers 2K Following Working hard to bring novel therapies & drug combinations to blood cancer patient.Tweets are my own #precisionmedicine #mmsm #leusm #lymsmNavneet Majhail, MD, .. @BldCancerDoc
21K Followers 942 Following Physician-in-Chief of Blood Cancers @SarahCannonDocs @HCAhealthcare | President @ASTCT 2019 | #BMTsm #CARTcell #CellTherapyMehdi Hamadani, MD @MediHumdani
11K Followers 3K Following BMT & Cellular Therapy | Secretary @ASTCT | Co-Chair @ASTCT CoPG | #bmtsm #CARTcell #lymsm | Personal views | Physician not Provider | 🇵🇰 🏏 🇺🇸 🏈Bruno Paiva @BrunoPaiva_UNAV
3K Followers 342 Following Husband and father of 4! 🥋 Director Flow Cytometry Core - CIMA LAB Diagnostics Director Myeloma Laboratory - Clinica & CIMA Universidad de NavarraJordan Schecter, MD @MyelomaRnD
258 Followers 510 FollowingJanane F. Rahbani @RahbaniLab
317 Followers 225 Following Assistant Professor of Medicine- UChicago Hematology/Oncology @UChicagoHemOnc @uchicago. My lab is interested in the interplay between obesity and cancer.Carlyn Tan @CarlynRTanMD
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8K Followers 704 Following Professor, Dept of Leukemia, MD Anderson Cancer Center | Director, CAR-T Leukemia Program | #CLL #ALL #TcellRx | via @aiims_newdelhi | Tweets: my own opinionsIsrael @Israel
1.6M Followers 5K Following The official X account of the State of Israel (yes it’s really us) run by the @IsraelMFA teamAndres Gomez @GomezDLeonMD
5K Followers 1K Following Associate Professor @UANL Monterrey, Mexico. Interested in HSCT, acute leukemia in LMIC. ASTCT. LABMT. ASH. AMEH. SMTT. #bmtsm #leusm #mmsm #lymsm #GlobalBMTAnita D'Souza @adsouza_md
2K Followers 597 Following Amyloidosis and Multiple Myeloma clinician-scientist | Froedtert & Medical College of Wisconsin | #mmsm #amyloidosis #ALamyloidosisHang Quach @HangQuach1
502 Followers 80 Following Professor of Haematology, University of Melbourne; Haematologist, St.Vincents Hospital MelbourneAlder Timmy Knudsen @timmyknudsen43
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642 Followers 129 Following myeloma WM & amyloid expert at CBCI. opinions are mineJay Cuda @JayCuda
142K Followers 936 Following I post about #WhiteSox & sports stats • 35 • Golfer ⛳️ Woodworker🪚 MSU '11 Civil engineeringSteven Bradley, MD @StevenBradleyMD
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312K Followers 4K Following Co-founder of Boundless 🌍 Former Head of Speechwriting at 🇮🇱 Mission to UN. Author. Speaker. Write on.DoctorDueDiligence @DueDoctor
2K Followers 211 Following Pro 🇺🇸| Policy |Biotech Memes+Parody |Deeply Curious about Macro Biotech Landscape |All opinions are my own|Not Investment Advice | Health Conscious & Love 🌳Adam Schefter @AdamSchefter
11.0M Followers 4K Following ESPN Senior NFL Insider. Interview & Podcast Requests: [email protected] Host of the Adam Schefter Podcast https://t.co/oz43ix5jZUNitasha Sarswat @SarswatNitasha
401 Followers 224 Following Advanced Heart Failure and Transplant Cardiologist @UchicagoMedCraig Cole @CraigEmmittCole
312 Followers 259 Following Myeloma Doctor and Hematologist at MichiganState University,The OhioState,Karmanos dedicated to God,family,patient care and science!William F Parker, MD,.. @WF_Parker
4K Followers 858 Following Critical care | Assistant Prof @UChicagoPCCM and @UChicagoPHS | Assistant Director @MacLeanEthics | empirical bioethics, scarce medical resource allocationEmily Escue, MD @EmilyEscue
891 Followers 2K Following Palliative Med doc and Geriatrician TN➡️IL➡️MN. #geripal #hapc Loves lit, lakes, and UT football. Views are my own.Spot News @SPOTNEWSonIG
172K Followers 66 Following What I tweet comes from multiple SCANNERS in real-time, #TrustButVerify this convicted felon. Donations are appreciated. https://t.co/IJJ6wgtc0PMarco Bonilla @Nephr0s
970 Followers 755 Following Assistant Professor of Medicine @uofcneph | GN/OncoNephrology | | Northwell NS/LIJ Nephrology class ‘22| Glomerular disease fellow @GlomCon class ‘22Claudio Cerchione @DottorClaudio
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820 Followers 1K Following PGY-1 Combined Internal Medicine and Pediatrics @UChicagoMedPeds | Postdoctoral Researcher @DanaFarber @harvardmed | MD ‘20 @AUB_LebanonBrade DeBriere @bdebriere
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189 Followers 74 FollowingAjai Chari @AjaiChari
756 Followers 192 Following Director of Multiple Myeloma Program and Professor of Clinical Medicine, University of California San Francisco. Views are my own.Prashant Sharma, MD, .. @psharmaMD
466 Followers 717 Following Attending- Malignant Hem/ BMT/ Cellular Therapy @Intermountain, SLC, UT.Paula Rodriguez-Otero @paurotero
1K Followers 309 Following Hematologist working at the Clínica Universidad de Navarra, focused on multiple myeloma.Santiago Thibaud, MD @SantiagoThibaud
480 Followers 503 Following Multiple myeloma, data science & precision medicine #mmsm Assistant Professor at @TischCancer @IcahnMountSinai #IMG from 🇦🇷, father & amateur musician🎼Nikhil C. Munshi, MD @NikhilMunshiMD
995 Followers 66 Following Kraft family chair and Myeloma doctor @danafarber, Professor @harvardmed, President @Myeloma_Society, and Asso. Editor @BloodAdvancesNoemi Puig @NoemiPuig2
77 Followers 128 FollowingClement Lee, MD, MSc @ClementLeeMD
13K Followers 3K Following Med-Peds Hospitalist 👶🏼👵🏽 @NewtonWellesley/@MassGenBrigham via @PennMedicine/@ChildrensPhila | ✍🏻@NEJM | Tweets my own/do not represent employersGurbakhash Kaur @GKaurMD
1K Followers 1K Following Multiple Myeloma Specialist at UTSW Harold C. Simmons Comprehensive Cancer Center | Montefiore & Tufts Alum@JanakiramMurali @ManniMD1 @HadidiSamer Nice point Murali. MRD is welcome in relapsed disease and gets drugs approved faster. Newly diagnosed: not so sure. Probably not much worse than PFS but less incentive to follow for late AEs (malignancy, infections, MDS etc). Hopefully FDA will reign things in in the AA setting.
THIS is the post I was looking for! Thank you @bdermanmd . Makes me feel better
@ManniMD1 If you look at the responses from FDA in the actual briefing document, I think you will be surprised at the large differences in MRD negativity that will be likely be required. Maybe easier with relapsed/refractory.
This patient is in the category of lowest absolute risk of PFS event -Standard risk with deep response. In an age range that benefit of ASCT is extrapolation. I advised her she is likely to do extremely well without it. But could proceed with ASCT if she feels strong 8/X
@End_myeloma And we will say “Do we still accept results of CARTITUDE-6 in the era of bsAb induction?”
One of the conundrums we have in MM care! Great points @End_myeloma. What is the incremental value of doing SCT? What is the NNT for a given outcome. Here a p value is irrelevant. It is highly likely SCT adds to the level of control, to at least some. But at what cost (NNT)?
WOW! This got more feedback than I expected. My recommendation was to forego ASCT altogether. Let me elaborate my rationale #mmsm @ManniMD1 @SusanBal9 @MayoMyeloma @Phari @MyelomaTeacher @Rfonsi1 @HealthTree @rajshekharucms 1/X
Congratulations to @HiraSMian Hugely deserving recipient of the @CDNCancerTrials Ralph Meyer New Investigator Award #woMMen
My coMMit colleagues are answering this question on a randomized trial. @bhemato @nsc_natalie @TMSchmidtMD @ldandersonjr @schadeh @rajshekharucms. 9/X
I consider collect stem cells, deferral of ASCT not a good idea for a 74 yo with upfront QUAD. If MM progresses in 1-2 years, no evidence of benefit of ASCT then. if MM relapses later, transplant less and less appealing with aging. 10/X
80+ times/year I personally treat someone with ASCT. For most it is a rough few weeks. For a few it can have deeper impact in their lives, physical and mental health. Patients tell me they want us to work on better outcomes, but also on better experience with treatments. 11/11
WOW! This got more feedback than I expected. My recommendation was to forego ASCT altogether. Let me elaborate my rationale #mmsm @ManniMD1 @SusanBal9 @MayoMyeloma @Phari @MyelomaTeacher @Rfonsi1 @HealthTree @rajshekharucms 1/X
#mmsm pulse check. Patient seen last week for discussion of ASCT, 74 yo, standard risk disease, D-VRd x 6-> sCR with MRD = 1 x 10-6. No relevant comorbidities. What would you recommend?
Achievement of MRD negativity 1 year after transplant is associated with improved progression-free and overall survival. Congrats to Dr. Pasquini and the BMT CTN 0702 / STaMINA investigators! pubmed.ncbi.nlm.nih.gov/38701390/
CD56 expression predicts response to Daratumumab-based regimens | Blood Cancer Journal nature.com/articles/s4140…
@RahulBanerjeeMD @VincentRK @OncLive @MayoMyeloma @MayoClinic Or at least put a space between MRD and NEG. I keep being called Mr. Dneg!
Congrats to my friend and colleague @Rfonsi1 for being selected as a Giants of Cancer Care Inductee for 2024. @OncLive @MayoMyeloma @MayoClinic
I don't disagree. It's not unreasonable. Two of my most despised turns of phrase.
@Taxkourel @RahulBanerjeeMD @paurotero @szusmani @MeeraMohanMD The mass spec assays such as mass-fix and exent should work quite nicely here as they calculate how much of the total immunoglobulin level is due to the monoclonal protein by calculating the percentage area represented by the monoclonal peak from the total ig value
Do cutting-edge CAR-T-cell therapies cause cancer? What the data say Appreciate the opportunity to comment on the topic. nature.com/articles/d4158…
@Taxkourel @paurotero @szusmani @MeeraMohanMD Agreed - @bdermanmd and his team published a study where they just converted the M-spike units from the SPEP and subtracted it from the total IgG… … I still feel a little dirty about switching between lab assays so freely, but it makes sense!
Just out: International Myeloma Working Group guidelines for bispecific antibodies myeloma. Limited time: Free copy link in the thread. @TheLancetOncol @paurotero @JKaufmanMD @szusmani @YiLinMDPhD @TomBmt133 @mvmateos @bdermanmd @MinnemaMonique et al thelancet.com/journals/lanon…
The 95% CI for where the rainbow ends totally includes my clinic at @fredhutch - just need to get that pesky I-5 off-ramp out of the way 😉